Abstract：
PURPOSE:4-[(18)F]-ADAM is a potent serotonin transport imaging agent. We studied its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken. METHODS:Single and multiple-dosage toxicity studies were conducted in Sprague-Dawley rats. Male and female rats were injected intravenously with 4-F-ADAM as a single dose of 1,023.7 microg/kg (1,000 times the human dose) or as five consecutive daily doses of 102.37 microg/kg (100 times the human dose). PET/CT scans were performed in seven Formosa Rock monkeys (four males and three females) using a Siemens Biograph scanner. After injection of 4-[(18)F]-ADAM (182+/-8 MBq), a low dose CT scan and a series of eight whole-body PET scans were performed. Whole-body images were acquired in 3-D mode. Time-activity data of source organs were used to calculate the residence times and estimate the absorbed radiation dose using OLINDA/EXM software. RESULTS:In the rats neither the single dose nor the five daily doses of 4-F-ADAM produced overt adverse effects clinically. In the monkeys the radiation doses received by most organs ranged between 7.1 and 35.7 microGy/MBq, and the urinary bladder was considered to be the critical organ. The effective doses extrapolated to male and female adult humans were 17.4 and 21.8 microSv/MBq, respectively. CONCLUSION:Toxicity studies in Sprague-Dawley rats and radiation dosimetry studies in Formosa Rock monkeys suggested that 4-[(18)F]-ADAM is safe for use in human PET imaging studies.
journal_name
Eur J Nucl Med Mol Imagingauthors
Huang YY,Ma KH,Tseng TW,Chou TK,Ng H,Mirsalis JC,Fu YK,Chu TC,Huang WS,Shiue CYdoi
10.1007/s00259-009-1281-zsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
545-55issue
3eissn
1619-7070issn
1619-7089journal_volume
37pub_type
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2013-01-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2016-11-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2016-03-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2007-03-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
abstract：PURPOSE:Penile cancer (PC) is a rare neoplasm with an aggressive behavior and variable prognosis. Lymph node (LN) involvement and pathological features of the primary lesion have been proven to be the most important survival factors. Positron emission tomography/computed tomography with fluorodeoxyglucose labelled with...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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journal_title：European journal of nuclear medicine and molecular imaging
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pub_type： 杂志文章,多中心研究
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,meta分析
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,评审
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 临床试验,杂志文章
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更新日期：2004-12-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
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更新日期：2003-09-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To assess the localizing value of 18F-FDG PET in patients operated on for drug-resistant epilepsy due to focal cortical dysplasia type 2 (FCD2). METHODS:We analysed 18F-FDG PET scans from 103 consecutive patients (52 males, 7-65 years old) with histologically proven FCD2. PET and MRI data were first reviewed b...
journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
doi：10.1007/s00259-017-3718-0
更新日期：2017-09-01 00:00:00
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journal_title：European journal of nuclear medicine and molecular imaging
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
