Abstract:
PURPOSE:Quantitative image reconstruction in positron emission tomography (PET) requires an accurate attenuation map of the object under study for the purpose of attenuation correction. Current dual-modality PET/CT systems offer significant advantages over stand-alone PET, including decreased overall scanning time and increased accuracy in lesion localisation and detectability. However, the contamination of CT data with scattered radiation and misclassification of contrast medium with high-density bone in CT-based attenuation correction (CTAC) are known to generate artefacts in the attenuation map and thus the resulting PET images. The purpose of this work was to quantitatively measure the impact of scattered radiation and contrast medium on the accuracy of CTAC. METHODS:Our recently developed MCNP4C-based Monte Carlo X-ray CT simulator for modelling both fan- and cone-beam CT scanners and the Eidolon dedicated 3D PET Monte Carlo simulator were used to generate realigned PET/CT data sets. The impact of X-ray scattered radiation on the accuracy of CTAC was investigated through simulation of a uniform cylindrical water phantom for both a commercial fan-beam multi-slice and a prototype cone-beam flat panel detector-based CT scanner. The influence of contrast medium was studied by simulation of a cylindrical phantom containing different concentrations of contrast medium. Moreover, an experimental study using an anthropomorphic striatal phantom was conducted for quantitative evaluation of errors arising from the presence of contrast medium by calculating the apparent recovery coefficient (ARC) in the presence of different concentrations of contrast medium. RESULTS:The analysis of attenuation correction factors (ACFs) for the simulated cylindrical water phantom in both fan- and cone-beam CT scanners showed that the contamination of CT data with scattered radiation in the absence of scatter removal causes underestimation of the true ACFs, namely by 7.3% and 28.2% in the centre for the two geometries, respectively. The ARC was 190.7% for a cylindrical volume of interest located in the main chamber of the striatal phantom containing contrast medium corresponding to 2,000 Hounsfield units, whereas the ARC was overestimated by less than 5% for the main chamber and by approximately 2% for the left/right putamen and caudate nucleus compared with the absence of contrast medium. CONCLUSION:Without X-ray scatter compensation, the visual artefacts and quantitative errors in flat panel detector-based cone-beam geometry are substantial and propagate cupping artefacts to PET images during CTAC. Likewise, contrast-enhanced CT images may create considerable artefacts during CTAC in regions containing high concentrations of contrast medium.
journal_name
Eur J Nucl Med Mol Imagingauthors
Ay MR,Zaidi Hdoi
10.1007/s00259-006-0086-6subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1301-13issue
11eissn
1619-7070issn
1619-7089journal_volume
33pub_type
杂志文章abstract:PURPOSE:The molecular imaging of tumour neoangiogenesis currently represents a major field of research for the diagnostic and treatment strategy of solid tumours. Endothelial cells from tumour neovessels overexpress the alpha(v)beta(3) integrin, which selectively binds to Arg-Gly-Asp (RGD)-containing peptides. We evalu...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-007-0497-z
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:This meta-analysis summarized the accuracy of stress myocardial perfusion scintigraphy (MPS) and stress echocardiography for the diagnosis of coronary artery disease (CAD) in patients with arterial hypertension. METHODS:We searched for studies in which stress MPS or stress echocardiography were performed to de...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,meta分析
doi:10.1007/s00259-011-1891-0
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic potential of PET/MRI with [(18)F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. METHODS:A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [(18)F]FDG PET/CT were su...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Increasing evidence supports the value of peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours (NET), but there are limited data on its specific efficacy in NET of small intestinal (midgut) origin. This study aims to define the benefit of PRRT with (177)Lu-octreotate f...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
doi:10.1007/s00259-011-1819-8
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative spine infection has not yet been established. The aim of this prospective multicenter study was to assess the diagnostic performance of three imaging modalities in ...
journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-020-05109-x
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,多中心研究
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更新日期:2016-04-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,实务指引
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更新日期:2012-01-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-008-0870-6
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
doi:10.1007/s00259-018-3986-3
更新日期:2018-07-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章,评审
doi:10.1007/s00259-012-2310-x
更新日期:2013-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 临床试验,杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
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更新日期:2013-02-01 00:00:00
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journal_title:European journal of nuclear medicine and molecular imaging
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00