Comparison of the crystal and solution structures of calmodulin and troponin C.

Abstract:

:X-ray solution scattering data from skeletal muscle troponin C and from calmodulin have been measured. Modeling studies based on the crystal structure coordinates for these proteins show discrepancies between the solution data and the crystal structure that indicate that if the size and shape of the globular domains are the same in solution as in the crystal, the distances between them must be smaller by several angstroms. Bringing the globular domains closer together requires structural changes in the interconnecting helix that joins them.

journal_name

Biochemistry

journal_title

Biochemistry

authors

Heidorn DB,Trewhella J

doi

10.1021/bi00403a011

subject

Has Abstract

pub_date

1988-02-09 00:00:00

pages

909-15

issue

3

eissn

0006-2960

issn

1520-4995

journal_volume

27

pub_type

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