Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.

abstract：:Immune responses and the components of protective immunity following norovirus infection in humans are poorly understood. Although antibody responses following norovirus infection have been partially characterized, T cell responses in humans remain largely undefined. In contrast, T cells have been shown to be essentia...

journal_title：Journal of virology

authors： LoBue AD,Lindesmith LC,Baric RS

更新日期：2010-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded molecules have been detected in the tumor tissues of several cancers, including nasopharyngeal carcinoma (NPC), suggesting that EBV plays an important role in tumorigenesis. However, the nature of EBV with respect to genome width in vivo and whether EBV undergoes clonal expansion in th...

journal_title：Journal of virology

authors： Liu P,Fang X,Feng Z,Guo YM,Peng RJ,Liu T,Huang Z,Feng Y,Sun X,Xiong Z,Guo X,Pang SS,Wang B,Lv X,Feng FT,Li DJ,Chen LZ,Feng QS,Huang WL,Zeng MS,Bei JX,Zhang Y,Zeng YX

更新日期：2011-11-01 00:00:00

abstract：:Cleavage of varicella-zoster virus DNA with the restriction endonucleases PstI, XbaI, and BglII resulted in 18, 22, and 20 fragments, respectively. Based on the molecular weights and molarities of these fragments, a molecular weight of 84 x 10(6) could be calculated for the varicella-zoster virus genome. In both the X...

journal_title：Journal of virology

authors： Dumas AM,Geelen JL,Weststrate MW,Wertheim P,van der Noordaa J

更新日期：1981-08-01 00:00:00

abstract：:Genotype 1 hepatitis E viruses (HEVs) are restricted to primate hosts, whereas genotype 3 HEVs predominantly infect swine, in addition to primates. In order to identify possible determinants of the host range, infectious recombinant viruses and chimeras of a genotype 1 isolate and a genotype 3 isolate were compared fo...

journal_title：Journal of virology

authors： Nguyen HT,Shukla P,Torian U,Faulk K,Emerson SU

更新日期：2014-01-01 00:00:00

abstract：:The transforming proteins of the small DNA tumor viruses, simian virus 40 (SV40), adenovirus, and human papillomavirus (HPV) target a number of identical cellular regulators whose functional abrogation is required for transformation. However, while both adenovirus E1A and SV40 large T transforming properties also depe...

journal_title：Journal of virology

authors： Zimmermann H,Degenkolbe R,Bernard HU,O'Connor MJ

更新日期：1999-08-01 00:00:00

abstract：:Adeno-associated virus (AAV) is a single-stranded DNA virus with a unique biphasic lifestyle consisting of both a productive and a latent phase. Typically, the productive phase requires coinfection with a helper virus, for instance adenovirus, while the latent phase dominates in healthy cells. In the latent state, AAV...

journal_title：Journal of virology

authors： Hamilton H,Gomos J,Berns KI,Falck-Pedersen E

更新日期：2004-08-01 00:00:00

abstract：:Hpt-13 is a Chinese hamster cell line deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and sensitive to a medium containing 10(-4) M hypoxanthine, 5.5 X 10(-6) M aminopterin, and 10(-4) M thymidine. In this cell line there is a high incidence of cells resistant to this selective medium after an incubat...

journal_title：Journal of virology

authors： Marengo C,Mbikay M,Weber J,Thirion JP

更新日期：1981-04-01 00:00:00

abstract：:Detailed phylogenetic analyses were performed to characterize an HIV-1 outbreak among injection drug users (IDUs) in Stockholm, Sweden, in 2006. This study investigated the source and dynamics of HIV-1 spread during the outbreak as well as associated demographic and clinical factors. Seventy Swedish IDUs diagnosed dur...

journal_title：Journal of virology

authors： Skar H,Axelsson M,Berggren I,Thalme A,Gyllensten K,Liitsola K,Brummer-Korvenkontio H,Kivelä P,Spångberg E,Leitner T,Albert J

更新日期：2011-01-01 00:00:00

abstract：:The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as...

journal_title：Journal of virology

authors： Maurer B,Serfling E,ter Meulen V,Rethwilm A

更新日期：1991-11-01 00:00:00

abstract：:We observed two patterns of chemokine expression in the lungs of mice infected with murine gammaherpesvirus 68: peaks of chemokine expression correlated with or occurred after the peak of viral gene expression. Chemokine expression remained elevated through 29 days postinfection. ...

journal_title：Journal of virology

authors： Weinberg JB,Lutzke ML,Efstathiou S,Kunkel SL,Rochford R

更新日期：2002-10-01 00:00:00

abstract：:By pretreating simian virus 40-infected BSC-1 cells with glucosamine, [(3)H]uridine labeling of both cellular and viral RNA can be halted instantaneously by addition of cold uridine. We have studied the fate of pulse-labeled viral RNA from cells at 45 h postinfection under these conditions. During a 5-min period of la...

journal_title：Journal of virology

authors： Chiu NH,Radonovich MF,Thoren MM,Salzman NP

更新日期：1978-11-01 00:00:00

abstract：:Previous studies have established that chlorella viruses encode K(+) channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs(+) to determine if the membrane depolarization observed during virus infection is caused by the activit...

journal_title：Journal of virology

authors： Frohns F,Käsmann A,Kramer D,Schäfer B,Mehmel M,Kang M,Van Etten JL,Gazzarrini S,Moroni A,Thiel G

更新日期：2006-03-01 00:00:00

abstract：:Two murine leukemia viruses were isolated from JLS-V9 cells which had been infected with Rauscher plasma virus. One virus was XC positive and failed to grow on mink or cat cells and thus was an ecotropic virus. The other virus formed cytopathic foci on mink cells, was XC negative, and fell into the mink cell focus-for...

journal_title：Journal of virology

authors： Schultz A,Rein A,Henderson L,Oroszlan S

更新日期：1983-03-01 00:00:00

abstract：:GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely wi...

journal_title：Journal of virology

authors： Takenouchi N,Jones KS,Lisinski I,Fugo K,Yao K,Cushman SW,Ruscetti FW,Jacobson S

更新日期：2007-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality. Previous studies have suggested that T-cell responses may contribute to RSV immunopathology, which could be driven by dendritic cells (DCs). DCs are productively infected by RSV, and during RSV infections, there is an increase of DCs in the...

journal_title：Journal of virology

authors： Thornburg NJ,Shepherd B,Crowe JE Jr

更新日期：2010-12-01 00:00:00

abstract：:Changes in the envelope glycoprotein ectodomains of a nonpathogenic simian-human immunodeficiency virus (SHIV-89.6) that was serially passaged in vivo have been shown to be responsible for the increased pathogenicity of the resulting virus, SHIV-KB9 (G. B. Karlsson, et al., J. Exp. Med. 188:1159-1171, 1998). The 12 am...

journal_title：Journal of virology

authors： Etemad-Moghadam B,Sun Y,Nicholson EK,Fernandes M,Liou K,Gomila R,Lee J,Sodroski J

更新日期：2000-05-01 00:00:00

abstract：:The antiviral effects of nitric oxide (NO) on Japanese encephalitis virus (JEV), a member of the family Flaviviridae, were investigated in this study. In vitro, inhibition of replication of JEV in gamma interferon-activated RAW 264.7 murine macrophages was correlated to cellular NO production. When cocultured with inf...

journal_title：Journal of virology

authors： Lin YL,Huang YL,Ma SH,Yeh CT,Chiou SY,Chen LK,Liao CL

更新日期：1997-07-01 00:00:00

abstract：:We have developed a complementation assay, using transiently transfected COS cells, to facilitate a molecular analysis of the herpes simplex virus type 1 glycoprotein gH. When infected by a gH-null syncytial virus, COS cells expressing wild-type gH generate infectious progeny virions and form a syncytium with neighbor...

journal_title：Journal of virology

authors： Wilson DW,Davis-Poynter N,Minson AC

更新日期：1994-11-01 00:00:00

abstract：:In an attempt to identify the molecules involved in the pathogenesis of prion diseases, we performed cDNA subtraction on the brain tissues of mice affected with an experimental prion disease and the unaffected control. The genes identified as being upregulated in the prion-affected brain tissue included those encoding...

journal_title：Journal of virology

authors： Kopacek J,Sakaguchi S,Shigematsu K,Nishida N,Atarashi R,Nakaoke R,Moriuchi R,Niwa M,Katamine S

更新日期：2000-01-01 00:00:00

abstract：:In vitro transcription of the avian tumor virus RNA by RNA-directed DNA polymerase is initiated on the unique cellular 4S RNA. Previous studies have shown that on the average there is one such RNA primer hydrogen bonded to each viral 35S RNA. The present study confirms that finding and demonstrates that, at least for ...

journal_title：Journal of virology

authors： Taylor JM,Illmensee R

更新日期：1975-09-01 00:00:00

abstract：:In this report, we describe the isolation, molecular genetic mapping, and phenotypic characterization of vaccinia virus mutants resistant to cytosine arabinoside (araC) and phosphonoacetic acid (PAA). At 37 degrees C, 8 microM araC was found to prevent macroscopic plaque formation by wild-type virus and to cause a 10(...

journal_title：Journal of virology

authors： Taddie JA,Traktman P

更新日期：1993-07-01 00:00:00

abstract：:Several independent cell lines transformed by simian virus 40 carry a species of viral RNA of 900,000 to 1,000,000 daltons. A viral RNA species of similar size is found early in the lytic cycle. Late in the viral lytic cycle, two prominent viral RNA species of about 600,000 and 900,000 daltons are seen. The larger lat...

journal_title：Journal of virology

authors： Weinberg RA,Ben-Ishai Z,Newbold JE

更新日期：1974-06-01 00:00:00

abstract：:We molecularly cloned the src coding region of tsNY68, a mutant of Rous sarcoma virus temperature sensitive (ts) for transformation, and constructed a series of ts wild-type recombinant src genes. DNA containing the hybrid genes was transfected into chicken cells together with viral vector DNA and helper viral DNA, an...

journal_title：Journal of virology

authors： Nishizawa M,Mayer BJ,Takeya T,Yamamoto T,Toyoshima K,Hanafusa H,Kawai S

更新日期：1985-12-01 00:00:00

abstract：:The ecotropic Cas-Br-E murine leukemia virus (MuLV) and its molecularly cloned derivative pBR-NE-8 MuLV are capable of inducing hind-limb paralysis and leukemia after inoculation into susceptible mice. T1 oligonucleotide fingerprinting, molecular hybridization, and restriction enzyme analysis previously showed that th...

journal_title：Journal of virology

authors： Rassart E,Nelbach L,Jolicoeur P

更新日期：1986-12-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) entry inhibitor eCD4-Ig is a fusion of CD4-Ig and a coreceptor-mimetic peptide. eCD4-Ig is markedly more potent than CD4-Ig, with neutralization efficiencies approaching those of HIV-1 broadly neutralizing antibodies (bNAbs). However, unlike bNAbs, eCD4-Ig neutralized al...

journal_title：Journal of virology

authors： Fetzer I,Gardner MR,Davis-Gardner ME,Prasad NR,Alfant B,Weber JA,Farzan M

更新日期：2018-05-29 00:00:00

abstract：:Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular...

journal_title：Journal of virology

authors： Inoue J,Ninomiya M,Umetsu T,Nakamura T,Kogure T,Kakazu E,Iwata T,Takai S,Sano A,Fukuda M,Watashi K,Isogawa M,Tanaka Y,Shimosegawa T,McNiven MA,Masamune A

更新日期：2019-07-17 00:00:00

abstract：:Glycosylation of the envelope glycoprotein of vesicular stomatitis virus was examined using virus-infected HeLa cells that were pulse-labeled with radioactive sugar precursors. The intracellular sites of glycosylation and the stepwise elongation of the carbohydrate side chains of the G protein were monitored by membra...

journal_title：Journal of virology

authors： Hunt LA,Summers DF

更新日期：1976-12-01 00:00:00

abstract：:Live attenuated human immunodeficiency virus type 1 (HIV-1) vaccines are considered unsafe because faster-replicating pathogenic virus variants may evolve after vaccination. We previously presented a conditional-live HIV-1 variant of which replication can be switched off as an alternative vaccination strategy. To impr...

journal_title：Journal of virology

authors： Das AT,Baldwin CE,Vink M,Berkhout B

更新日期：2005-03-01 00:00:00

abstract：:Infection of primary fibroblasts with human cytomegalovirus (HCMV) causes a rapid stabilization of the cellular protein p53. p53 is a major effector of the cellular damage response, and activation of this transcription factor can lead either to cell cycle arrest or to apoptosis. Viruses employ many tactics to avoid p5...

journal_title：Journal of virology

authors： Casavant NC,Luo MH,Rosenke K,Winegardner T,Zurawska A,Fortunato EA

更新日期：2006-09-01 00:00:00

abstract：:Boid inclusion body disease (BIBD) is a transmissible viral disease of captive snakes that causes severe losses in snake collections worldwide. It is caused by reptarenavirus infection, which can persist over several years without overt signs but is generally associated with the eventual death of the affected snakes. ...

journal_title：Journal of virology

authors： Argenta FF,Hepojoki J,Smura T,Szirovicza L,Hammerschmitt ME,Driemeier D,Kipar A,Hetzel U

更新日期：2020-05-18 00:00:00