KL-6 is another useful marker in assessing a micropapillary pattern in carcinomas of the breast and urinary bladder, but not the colon.

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that th...

journal_title：Medical molecular morphology

authors： Matsuda Y,Wakai T,Kubota M,Takamura M,Yamagiwa S,Aoyagi Y,Osawa M,Fujimaki S,Sanpei A,Genda T,Ichida T

更新日期：2013-12-01 00:00:00

abstract：:The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...

journal_title：Medical molecular morphology

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2015-09-01 00:00:00

abstract：:Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017...

journal_title：Medical molecular morphology

authors： Takahashi A,Ohira H,Abe K,Zeniya M,Abe M,Arinaga-Hino T,Torimura T,Yoshizawa K,Takaki A,Kang JH,Suzuki Y,Nakamoto N,Inui A,Tanaka A,Takikawa H

更新日期：2020-05-15 00:00:00

abstract：:The normal mammary gland can be roughly divided into the large duct close to the nipple and the terminal duct located within the lobulus. Both the large duct and the terminal duct are composed of epithelial cells and myoepithelial cells. The epithelial cells can be divided into light and dark cells using electron dens...

journal_title：Medical molecular morphology

authors： Tsuchiya S,Li F

更新日期：2005-12-01 00:00:00

abstract：:Fibrates belong to a group of ligands of peroxisome proliferator-activated receptor alpha (PPARα), which play a role in the regulation of CYP epoxygenases and soluble epoxide hydrolase (sEH), key enzymes in the metabolism of biologically highly active epoxyeicosatrienoic acids (EETs). We demonstrated that low doses of...

journal_title：Medical molecular morphology

authors： Tauber Z,Koleckova M,Cizkova K

更新日期：2020-09-01 00:00:00

abstract：:Brush cells (BCs) are relatively rare cells that are sparsely distributed throughout the mammalian digestive and respiratory systems. BCs have been identified in the rodent large intestine, but these cells have not been characterized by immunocytochemistry or electron microscopy. We previously demonstrated that rat bi...

journal_title：Medical molecular morphology

authors： Okamoto K,Hanazaki K,Akimori T,Okabayashi T,Okada T,Kobayashi M,Ogata T

更新日期：2008-09-01 00:00:00

abstract：:Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...

journal_title：Medical molecular morphology

authors： Omote S,Takata K,Tanaka T,Miyata-Takata T,Ayada Y,Noujima-Harada M,Omote R,Tabata T,Sato Y,Toyokawa T,Kato H,Yagi T,Okada H,Yoshino T

更新日期：2018-12-01 00:00:00

abstract：:Malignant müllerian mixed tumors (MMMTs) of the fallopian tube are very rare neoplasms, and we present such a case with unusual findings here. A 57-year-old Japanese woman, after she received a medical checkup, underwent salpingo-oophorectomy on the suspicion of ovarian cancer. At the time of operation, the main tumor...

journal_title：Medical molecular morphology

authors： Kuroda N,Inui Y,Ohara M,Hirouchi T,Mizuno K,Kubo A,Hayashi Y,Enzan H,Lee GH

更新日期：2007-03-01 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectr...

journal_title：Medical molecular morphology

authors： Shimasaki N,Kuroda N,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H,Shuin T

更新日期：2007-12-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth ret...

journal_title：Medical molecular morphology

authors： Wang T,Onouchi T,Yamada NO,Matsuda S,Senda T

更新日期：2017-06-01 00:00:00

abstract：:Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...

journal_title：Medical molecular morphology

authors： Tofrizal A,Fujiwara K,Azuma M,Kikuchi M,Jindatip D,Yashiro T,Yamada S

更新日期：2017-09-01 00:00:00

abstract：:The Tian-Long (TL) compound is a water-soluble extract of six Chinese medicinal herbs. To explore its antitumor properties and the mechanism for activity in gynecological malignancies, the present studies were carried out using Ishikawa cells derived from uterine endometrial adenocarcinoma. Morphologically, cell death...

journal_title：Medical molecular morphology

authors： Li ZL,Morishima S,Tang JT,Otsuki Y

更新日期：2009-03-01 00:00:00

abstract：:Experimental pressure ulcers were successfully produced in the rat abdominal wall at 100 mmHg in our previous study. We hypothesized that injury is less severe when pressures are lower than 100 mmHg and explored a critical pressure in the production of pressure ulcers. At 70 and 60 mmHg, repeated compressions for 4 h ...

journal_title：Medical molecular morphology

authors： Kawamata S,Kurose T,Kubori Y,Muramoto H,Honkawa Y

更新日期：2015-03-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...

journal_title：Medical molecular morphology

authors： Hori M,Someya M,Matsumoto Y,Nakata K,Kitagawa M,Hasegawa T,Tsuchiya T,Fukushima Y,Gocho T,Sato Y,Ohnuma H,Kato J,Sugita S,Hasegawa T,Sakata KI

更新日期：2017-03-01 00:00:00

abstract：:We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular ...

journal_title：Medical molecular morphology

authors： Kaku N,Shimada T,Nogami R,Tagomori H,Tsumura H

更新日期：2020-09-01 00:00:00

abstract：:Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...

journal_title：Medical molecular morphology

authors： Yokomori H,Oda M,Yoshimura K,Watanabe S,Hibi T

更新日期：2010-03-01 00:00:00

abstract：:We examined the effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats. Three-week-old rats were kept on a diet containing either 12% protein (Lp rats) or 18% protein (Np rats) for 4 or 8 weeks after subtotal nephrectomy (SUNx). In Western blot analysi...

journal_title：Medical molecular morphology

authors： Mino M,Ihara H,Kozaki S,Kondo T,Takeshita A,Kusakabe KT,Okada T

更新日期：2010-06-01 00:00:00

abstract：:IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...

journal_title：Medical molecular morphology

authors： Kuroda N,Nakamura S,Miyazaki K,Inoue K,Ohara M,Mizuno K,Sato Y,Yoshino T

更新日期：2009-12-01 00:00:00

abstract：:Ameloblastoma (AB), which is the most common odontogenic tumor, may originate from the dental lamina remnants. The expression of CD56, which is a transmembrane molecule, is associated with neuroectodermal differentiation of the embryonal cells. The aim of this study was to evaluate the expression of CD56 in AB, in com...

journal_title：Medical molecular morphology

authors： Kusafuka K,Hirobe K,Wato M,Tanaka A,Nakajima T

更新日期：2011-06-01 00:00:00

abstract：:In the present study, we investigated the changes in the localization of the glucose transporter GLUT2 and the fructose transporter GLUT5 in small intestinal absorptive cells during postnatal development, especially during the weaning period, using immunohistochemistry and confocal laser scanning microscopy. In the je...

journal_title：Medical molecular morphology

authors： Baba R,Yamami M,Sakuma Y,Fujita M,Fujimoto S

更新日期：2005-03-01 00:00:00

abstract：:Desquamation in the mammalian skin is a well-balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein ...

journal_title：Medical molecular morphology

authors： Ishida-Yamamoto A,Kishibe M

更新日期：2011-03-01 00:00:00

abstract：:E-cadherin expression patterns in acinar cell carcinomas (ACCs) of the pancreas have not been well documented. Herein, we present a hitherto undescribed case of E-cadherin-negative ACC with a solid pseudopapillary growth pattern in a 65-year-old man. We used an antibody against the extracellular domain of E-cadherin. ...

journal_title：Medical molecular morphology

authors： Tajima S,Waki M,Azuma M,Koda K,Ohata A

更新日期：2016-09-01 00:00:00

abstract：:Helicobacter pylori possesses intrabacterial nanotransportation system (ibNoTS) for transporting CagA, VacA, and urease within the bacterial cytoplasm, which is controlled by the extrabacterial environment. The route of ibNoTS for CagA is reported to be associated with the MreB filament, whereas the route of ibNoTS fo...

journal_title：Medical molecular morphology

authors： Wu H,Iwai N,Suzuki Y,Nakano T

更新日期：2019-12-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...

journal_title：Medical molecular morphology

authors： Tanigawa M,Nakayama M,Taira T,Hattori S,Mihara Y,Kondo R,Kusano H,Nakamura K,Abe Y,Ishida Y,Okabe Y,Hisaka T,Okuda K,Fujino K,Ito T,Kawahara A,Naito Y,Yamaguchi R,Akiba J,Akagi Y,Yano H

更新日期：2018-03-01 00:00:00

abstract：:A 73-year-old woman showed marked exophytic growth of a tumor (25 × 23 × 14 mm) of the nipple over a period of 2 months. Histologically, numerous tumor nodules with no apparent keratinization were observed in the exophytic lesion. The tumor cells also showed little invasion to the dermis and no metastasis to the axill...

journal_title：Medical molecular morphology

authors： Hosaka N,Uesaka K,Takaki T,Zhang Y,Takasu K,Ikehara S

更新日期：2011-09-01 00:00:00

abstract：:Progression of liver fibrosis has been linked with injuries associated with hypoxia and neovascularization. Neovascularization consists of angiogenesis and vasculogenesis, representing formation of blood vessels by differentiation of endothelial progenitor cells (EPCs). We investigated antifibrogenic and regenerative ...

journal_title：Medical molecular morphology

authors： Ueno T,Nakamura T,Torimura T,Sata M

更新日期：2006-03-01 00:00:00

abstract：:Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...

journal_title：Medical molecular morphology

authors： Matsuo Y,Tashiro H,Yanai H,Moriya T,Katabuchi H

更新日期：2015-09-01 00:00:00

abstract：:Extra-gastrointestinal stromal tumors (E-GISTs) not associated with the alimentary tract in the pelvic cavity are extremely rare. We treated a 49-year-old Japanese man with such an E-GIST in the pelvic cavity who underwent an intrapelvic tumorectomy with a total prostatectomy and partial rectum resection. Gross examin...

journal_title：Medical molecular morphology

authors： Hirano H,Yoshida T,Yoshimura H,Fukuoka M,Ohmura N,Nishizawa Y,Tachibana S,Hirota S,Zozumi M,Nishigami T

更新日期：2012-06-01 00:00:00