Clinical significance of cell cycle inhibitors in hepatocellular carcinoma.

abstract：:A 73-year-old woman showed marked exophytic growth of a tumor (25 × 23 × 14 mm) of the nipple over a period of 2 months. Histologically, numerous tumor nodules with no apparent keratinization were observed in the exophytic lesion. The tumor cells also showed little invasion to the dermis and no metastasis to the axill...

journal_title：Medical molecular morphology

authors： Hosaka N,Uesaka K,Takaki T,Zhang Y,Takasu K,Ikehara S

更新日期：2011-09-01 00:00:00

abstract：:Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferas...

journal_title：Medical molecular morphology

authors： Shiraishi M,Doi Y,Kayashima K,Fujimoto S

更新日期：2008-03-01 00:00:00

abstract：:Renal cell carcinoma (RCC) represents over 80% of kidney cancer, and about 30% of the patients with RCC develop metastasis after the surgery. Invasion of basement membrane (BM) and extracellular matrix (ECM) is an essential event in tumor invasion and metastasis. Matrix metalloproteinases (MMPs), which digest the main...

journal_title：Medical molecular morphology

authors： Mikami S,Oya M,Mizuno R,Kosaka T,Katsube K,Okada Y

更新日期：2014-06-01 00:00:00

abstract：:In a case of metanephric adenoma of the kidney, many apical cytoplasmic blebs were found on the luminal surface of tumor cells. The tumor, measuring 15 mm in diameter, was found incidentally in the right kidney of a 40-year-old woman. It consisted of a dense proliferation of cuboidal cells forming small tubules of rou...

journal_title：Medical molecular morphology

authors： Shintaku M,Maeno K

更新日期：2016-03-01 00:00:00

abstract：:Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...

journal_title：Medical molecular morphology

authors： Shimomura A,Takasaki A,Nomura R,Hayashi N,Senda T

更新日期：2013-03-01 00:00:00

abstract：:Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P...

journal_title：Medical molecular morphology

authors： Hyo Y,Yamada S,Ishimatsu M,Fukutsuji K,Harada T

更新日期：2012-06-01 00:00:00

abstract：:Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...

journal_title：Medical molecular morphology

authors： Sakaue T,Koga H,Iwamoto H,Nakamura T,Ikezono Y,Abe M,Wada F,Masuda A,Tanaka T,Fukahori M,Ushijima T,Mihara Y,Naitou Y,Okabe Y,Kakuma T,Ohta K,Nakamura KI,Torimura T

更新日期：2019-12-01 00:00:00

abstract：:Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC1638T/1638T mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they...

journal_title：Medical molecular morphology

authors： Wenduerma,Yamada NO,Wang T,Senda T

更新日期：2021-01-25 00:00:00

abstract：:Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...

journal_title：Medical molecular morphology

authors： Matsuo Y,Tashiro H,Yanai H,Moriya T,Katabuchi H

更新日期：2015-09-01 00:00:00

abstract：:A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...

journal_title：Medical molecular morphology

authors： Kuroda N,Iwamura S,Fujishima N,Ohara M,Hirouchi T,Mizuno K,Hayashi Y,Lee GH

更新日期：2007-09-01 00:00:00

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...

journal_title：Medical molecular morphology

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2015-09-01 00:00:00

abstract：:Prolactinomas are the most common tumor of the human pituitary. They result in excessive prolactin secretion and important changes in the vasculature. Pericytes are perivascular cells associated with capillaries and have crucial roles in physiological and pathological neovascularization. We previously reported that pe...

journal_title：Medical molecular morphology

authors： Jindatip D,Fujiwara K,Sarachana T,Mutirangura A,Yashiro T

更新日期：2018-09-01 00:00:00

abstract：:We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular ...

journal_title：Medical molecular morphology

authors： Kaku N,Shimada T,Nogami R,Tagomori H,Tsumura H

更新日期：2020-09-01 00:00:00

abstract：:Ameloblastoma (AB), which is the most common odontogenic tumor, may originate from the dental lamina remnants. The expression of CD56, which is a transmembrane molecule, is associated with neuroectodermal differentiation of the embryonal cells. The aim of this study was to evaluate the expression of CD56 in AB, in com...

journal_title：Medical molecular morphology

authors： Kusafuka K,Hirobe K,Wato M,Tanaka A,Nakajima T

更新日期：2011-06-01 00:00:00

abstract：:The Tian-Long (TL) compound is a water-soluble extract of six Chinese medicinal herbs. To explore its antitumor properties and the mechanism for activity in gynecological malignancies, the present studies were carried out using Ishikawa cells derived from uterine endometrial adenocarcinoma. Morphologically, cell death...

journal_title：Medical molecular morphology

authors： Li ZL,Morishima S,Tang JT,Otsuki Y

更新日期：2009-03-01 00:00:00

abstract：:We herein report a variant case of desmoplastic small round cell tumor (DSRCT) showing limited desmoplasia and confusing immunohistochemical findings. A 26-year-old male was referred for multiple abdominal masses. Laparoscopic biopsy showed only the solid proliferation of small round cells, and he was initially diagno...

journal_title：Medical molecular morphology

authors： Kihara A,Takahashi K,Ishikawa A,Amano Y,Matsubara D,Kanda H,Sata N,Fukushima N,Niki T

更新日期：2020-09-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...

journal_title：Medical molecular morphology

authors： Tanigawa M,Nakayama M,Taira T,Hattori S,Mihara Y,Kondo R,Kusano H,Nakamura K,Abe Y,Ishida Y,Okabe Y,Hisaka T,Okuda K,Fujino K,Ito T,Kawahara A,Naito Y,Yamaguchi R,Akiba J,Akagi Y,Yano H

更新日期：2018-03-01 00:00:00

abstract：:Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017...

journal_title：Medical molecular morphology

authors： Takahashi A,Ohira H,Abe K,Zeniya M,Abe M,Arinaga-Hino T,Torimura T,Yoshizawa K,Takaki A,Kang JH,Suzuki Y,Nakamoto N,Inui A,Tanaka A,Takikawa H

更新日期：2020-05-15 00:00:00

abstract：:The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth ret...

journal_title：Medical molecular morphology

authors： Wang T,Onouchi T,Yamada NO,Matsuda S,Senda T

更新日期：2017-06-01 00:00:00

abstract：:The normal mammary gland can be roughly divided into the large duct close to the nipple and the terminal duct located within the lobulus. Both the large duct and the terminal duct are composed of epithelial cells and myoepithelial cells. The epithelial cells can be divided into light and dark cells using electron dens...

journal_title：Medical molecular morphology

authors： Tsuchiya S,Li F

更新日期：2005-12-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...

journal_title：Medical molecular morphology

authors： Hori M,Someya M,Matsumoto Y,Nakata K,Kitagawa M,Hasegawa T,Tsuchiya T,Fukushima Y,Gocho T,Sato Y,Ohnuma H,Kato J,Sugita S,Hasegawa T,Sakata KI

更新日期：2017-03-01 00:00:00

abstract：:Dusp22 (dual-specificity phosphatase 22) is considered to regulate various cellular processes through the regulation of protein dephosphorylation. In this study, we prepared a specific antibody against Dusp22, anti-Dusp22, and carried out expression analyses with mouse tissues and cultured cell lines. Western blotting...

journal_title：Medical molecular morphology

authors： Hamada N,Mizuno M,Tomita H,Iwamoto I,Hara A,Nagata KI

更新日期：2018-06-01 00:00:00

abstract：:We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectr...

journal_title：Medical molecular morphology

authors： Shimasaki N,Kuroda N,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H,Shuin T

更新日期：2007-12-01 00:00:00

abstract：:IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...

journal_title：Medical molecular morphology

authors： Kuroda N,Nakamura S,Miyazaki K,Inoue K,Ohara M,Mizuno K,Sato Y,Yoshino T

更新日期：2009-12-01 00:00:00

abstract：:Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...

journal_title：Medical molecular morphology

authors： Yokomori H,Oda M,Yoshimura K,Watanabe S,Hibi T

更新日期：2010-03-01 00:00:00

abstract：:Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinoge...

journal_title：Medical molecular morphology

authors： Adhikari BR,Uehara O,Matsuoka H,Takai R,Harada F,Utsunomiya M,Chujo T,Morikawa T,Shakya M,Yoshida K,Sato J,Arakawa T,Nishimura M,Nagayasu H,Chiba I,Abiko Y

更新日期：2017-09-01 00:00:00

abstract：:Desquamation in the mammalian skin is a well-balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein ...

journal_title：Medical molecular morphology

authors： Ishida-Yamamoto A,Kishibe M

更新日期：2011-03-01 00:00:00

abstract：:Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...

journal_title：Medical molecular morphology

authors： Tofrizal A,Fujiwara K,Azuma M,Kikuchi M,Jindatip D,Yashiro T,Yamada S

更新日期：2017-09-01 00:00:00

abstract：:Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...

journal_title：Medical molecular morphology

authors： Omote S,Takata K,Tanaka T,Miyata-Takata T,Ayada Y,Noujima-Harada M,Omote R,Tabata T,Sato Y,Toyokawa T,Kato H,Yagi T,Okada H,Yoshino T

更新日期：2018-12-01 00:00:00