Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process.

abstract：:A few studies of the morphogenesis of human herpesvirus (HHV) 6 type A and B (HHV-6A, -6B) have been performed using neurogenic, lymphoid, or epithelial cells. When human MT-4 T-lymphotropic virus type I (HTLV-I)-producing lymphoid cells were coinfected with HHV-6B in vitro, viral-specific proteins were clearly detect...

journal_title：Medical molecular morphology

authors： Ohtsuki Y,Daibata M,Bandobashi K,Lee GH,Furihata M,Yokoyama A,Miyoshi I

更新日期：2008-12-01 00:00:00

abstract：:It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that th...

journal_title：Medical molecular morphology

authors： Matsuda Y,Wakai T,Kubota M,Takamura M,Yamagiwa S,Aoyagi Y,Osawa M,Fujimaki S,Sanpei A,Genda T,Ichida T

更新日期：2013-12-01 00:00:00

abstract：:Non-invasive predictors for the development of cirrhosis-related conditions are needed for patients with primary biliary cholangitis (PBC). We investigated the association between cytokeratin-18 fragments (M30 and M65) and liver histology, treatment response and the development of cirrhosis-related conditions in patie...

journal_title：Medical molecular morphology

authors： Hayashi M,Abe K,Fujita M,Okai K,Takahashi A,Nozawa Y,Ohira H

更新日期：2018-09-01 00:00:00

abstract：:Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC1638T/1638T mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they...

journal_title：Medical molecular morphology

authors： Wenduerma,Yamada NO,Wang T,Senda T

更新日期：2021-01-25 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:In the human placenta, embryo-derived trophoblasts aggressively invade maternal spiral arteries and transform the arteries to low-resistance large-caliber vessels. This process, which ensures adequate placental perfusion, is called maternal vascular remodeling. Histological examination showed deposition of maternal pl...

journal_title：Medical molecular morphology

authors： Sato Y,Fujiwara H,Konishi I

更新日期：2010-09-01 00:00:00

abstract：:Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied...

journal_title：Medical molecular morphology

authors： Kanomata N,Yamaguchi R,Kurebayashi J,Moriya T

更新日期：2020-03-01 00:00:00

abstract：:IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...

journal_title：Medical molecular morphology

authors： Kuroda N,Nakamura S,Miyazaki K,Inoue K,Ohara M,Mizuno K,Sato Y,Yoshino T

更新日期：2009-12-01 00:00:00

abstract：:A 73-year-old woman showed marked exophytic growth of a tumor (25 × 23 × 14 mm) of the nipple over a period of 2 months. Histologically, numerous tumor nodules with no apparent keratinization were observed in the exophytic lesion. The tumor cells also showed little invasion to the dermis and no metastasis to the axill...

journal_title：Medical molecular morphology

authors： Hosaka N,Uesaka K,Takaki T,Zhang Y,Takasu K,Ikehara S

更新日期：2011-09-01 00:00:00

abstract：:Extra-gastrointestinal stromal tumors (E-GISTs) not associated with the alimentary tract in the pelvic cavity are extremely rare. We treated a 49-year-old Japanese man with such an E-GIST in the pelvic cavity who underwent an intrapelvic tumorectomy with a total prostatectomy and partial rectum resection. Gross examin...

journal_title：Medical molecular morphology

authors： Hirano H,Yoshida T,Yoshimura H,Fukuoka M,Ohmura N,Nishizawa Y,Tachibana S,Hirota S,Zozumi M,Nishigami T

更新日期：2012-06-01 00:00:00

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...

journal_title：Medical molecular morphology

authors： Matsuo Y,Tashiro H,Yanai H,Moriya T,Katabuchi H

更新日期：2015-09-01 00:00:00

abstract：:Generating mesenchymal stem-like cells (MSLCs) from induced pluripotent stem cells (iPSCs) can be a practical method for obtaining the sufficient cells for autologous tissue engineering. Single-cell culturing in specific medium and non-feeder cells is an alternative and promising strategy to overcome problems of embry...

journal_title：Medical molecular morphology

authors： Ueda M,Hashimoto Y,Honda Y,Baba S,Morita S

更新日期：2019-09-01 00:00:00

abstract：:The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...

journal_title：Medical molecular morphology

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2015-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...

journal_title：Medical molecular morphology

authors： Tamaru S,Kajihara T,Mizuno Y,Mizuno Y,Tochigi H,Ishihara O

更新日期：2020-09-01 00:00:00

abstract：:ArgBP2 is a member of the SoHo (sorbin-homology) family of adaptor proteins believed to play roles in cell adhesion, cytoskeletal organization, and signaling. We show here a novel splicing isoform of ArgBP2, i.e., ArgBP2™, composed of only three SH3 (src-homology 3) domains and structurally similar to vinexinß. We the...

journal_title：Medical molecular morphology

authors： Murase K,Ito H,Kanoh H,Sudo K,Iwamoto I,Morishita R,Soubeyran P,Seishima M,Nagata K

更新日期：2012-12-01 00:00:00

abstract：:Detachment of mesothelial cells is an early step in adhesion of the human pleura. To elucidate this process, we used adhesion molecules as the targets of primary antibody and performed immunohistochemical staining of the mesothelial cells that cover the surface of the sites of pleural adhesion and the macrophages that...

journal_title：Medical molecular morphology

authors： Amari M,Taguchi K,Iwahara M,Oharaseki T,Yokouchi Y,Naoe S,Takahashi K

更新日期：2006-12-01 00:00:00

abstract：:Vibrio cholerae colonizes the lumen of the proximal small intestine, which has an alkaline environment, and secretes cholera toxin (CT) through a type II secretion machinery. V. cholerae possesses the intrabacterial nanotransportation system (ibNoTS) for transporting CT from the inner portion toward the peripheral por...

journal_title：Medical molecular morphology

authors： Matsuzaki Y,Wu H,Nakano T,Nakahari T,Sano K

更新日期：2015-12-01 00:00:00

abstract：:A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...

journal_title：Medical molecular morphology

authors： Kuroda N,Iwamura S,Fujishima N,Ohara M,Hirouchi T,Mizuno K,Hayashi Y,Lee GH

更新日期：2007-09-01 00:00:00

abstract：:Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patie...

journal_title：Medical molecular morphology

authors： Hao H,Xia G,Wang C,Zhong F,Liu L,Zhang D

更新日期：2017-06-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...

journal_title：Medical molecular morphology

authors： Tanigawa M,Nakayama M,Taira T,Hattori S,Mihara Y,Kondo R,Kusano H,Nakamura K,Abe Y,Ishida Y,Okabe Y,Hisaka T,Okuda K,Fujino K,Ito T,Kawahara A,Naito Y,Yamaguchi R,Akiba J,Akagi Y,Yano H

更新日期：2018-03-01 00:00:00

abstract：:The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were...

journal_title：Medical molecular morphology

authors： Shibata MA,Shibata E,Maemura K,Kondo Y,Harada-Shiba M

更新日期：2017-09-01 00:00:00

abstract：:Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...

journal_title：Medical molecular morphology

authors： Sakaue T,Koga H,Iwamoto H,Nakamura T,Ikezono Y,Abe M,Wada F,Masuda A,Tanaka T,Fukahori M,Ushijima T,Mihara Y,Naitou Y,Okabe Y,Kakuma T,Ohta K,Nakamura KI,Torimura T

更新日期：2019-12-01 00:00:00

abstract：:We herein report a variant case of desmoplastic small round cell tumor (DSRCT) showing limited desmoplasia and confusing immunohistochemical findings. A 26-year-old male was referred for multiple abdominal masses. Laparoscopic biopsy showed only the solid proliferation of small round cells, and he was initially diagno...

journal_title：Medical molecular morphology

authors： Kihara A,Takahashi K,Ishikawa A,Amano Y,Matsubara D,Kanda H,Sata N,Fukushima N,Niki T

更新日期：2020-09-01 00:00:00

abstract：:We examined the effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats. Three-week-old rats were kept on a diet containing either 12% protein (Lp rats) or 18% protein (Np rats) for 4 or 8 weeks after subtotal nephrectomy (SUNx). In Western blot analysi...

journal_title：Medical molecular morphology

authors： Mino M,Ihara H,Kozaki S,Kondo T,Takeshita A,Kusakabe KT,Okada T

更新日期：2010-06-01 00:00:00

abstract：:Hair is one of the smallest organs, but has many important functions to mammals. Hair morphogenesis occurs through the reciprocal exchange of epithelial and mesenchymal signals. There are some reports about the expression of laminin-511 and -332 during hair morphogenesis, but are no reports of the chronological expres...

journal_title：Medical molecular morphology

authors： Imanishi H,Tsuruta D,Tateishi C,Sugawara K,Kobayashi H,Ishii M,Kishi K

更新日期：2014-03-01 00:00:00

abstract：:We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular ...

journal_title：Medical molecular morphology

authors： Kaku N,Shimada T,Nogami R,Tagomori H,Tsumura H

更新日期：2020-09-01 00:00:00

abstract：:To evaluate the peculiar "inside-out" pattern in micropapillary (MP) carcinoma, we investigated the usefulness of KL-6 antibody in the assessment of the MP pattern of cancers, in comparison with antibodies to epithelial membrane antigen (EMA), MUC1 (CD227), and CD 10. Immunohistochemical investigation was performed on...

journal_title：Medical molecular morphology

authors： Ohtsuki Y,Kuroda N,Umeoka T,Watanabe R,Ochi K,Okada Y,Lee GH,Furihata M

更新日期：2009-06-01 00:00:00

abstract：:Brush cells (BCs) are relatively rare cells that are sparsely distributed throughout the mammalian digestive and respiratory systems. BCs have been identified in the rodent large intestine, but these cells have not been characterized by immunocytochemistry or electron microscopy. We previously demonstrated that rat bi...

journal_title：Medical molecular morphology

authors： Okamoto K,Hanazaki K,Akimori T,Okabayashi T,Okada T,Kobayashi M,Ogata T

更新日期：2008-09-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...

journal_title：Medical molecular morphology

authors： Hori M,Someya M,Matsumoto Y,Nakata K,Kitagawa M,Hasegawa T,Tsuchiya T,Fukushima Y,Gocho T,Sato Y,Ohnuma H,Kato J,Sugita S,Hasegawa T,Sakata KI

更新日期：2017-03-01 00:00:00