Abstract:
:Detachment of mesothelial cells is an early step in adhesion of the human pleura. To elucidate this process, we used adhesion molecules as the targets of primary antibody and performed immunohistochemical staining of the mesothelial cells that cover the surface of the sites of pleural adhesion and the macrophages that migrate from connective tissue. The surface of the adhesion site that was formed as a result of edematous and villiform elongation of the connective tissue underlying the visceral pleura was covered with mesothelial cells. However, there was partial detachment of the mesothelial cells caused by adherence to macrophages that had migrated from within the connective tissue, and that adherence was mediated by adhesion molecules. We demonstrated that both mesothelial cells and macrophages each express both CD54 and CD11a, important adhesion molecules. It was surmised that the detachment of the mesothelial cells is the result of interaction with the macrophages via those adhesion molecules and that over time it progresses to pleural adhesion.
journal_name
Med Mol Morpholjournal_title
Medical molecular morphologyauthors
Amari M,Taguchi K,Iwahara M,Oharaseki T,Yokouchi Y,Naoe S,Takahashi Kdoi
10.1007/s00795-006-0340-9subject
Has Abstractpub_date
2006-12-01 00:00:00pages
187-92issue
4eissn
1860-1480issn
1860-1499journal_volume
39pub_type
杂志文章abstract::The normal mammary gland can be roughly divided into the large duct close to the nipple and the terminal duct located within the lobulus. Both the large duct and the terminal duct are composed of epithelial cells and myoepithelial cells. The epithelial cells can be divided into light and dark cells using electron dens...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-005-0300-9
更新日期:2005-12-01 00:00:00
abstract::DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-016-0144-5
更新日期:2017-03-01 00:00:00
abstract::Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-012-0002-z
更新日期:2013-03-01 00:00:00
abstract::Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-018-0197-8
更新日期:2018-12-01 00:00:00
abstract::Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-011-0540-9
更新日期:2012-06-01 00:00:00
abstract::Progression of liver fibrosis has been linked with injuries associated with hypoxia and neovascularization. Neovascularization consists of angiogenesis and vasculogenesis, representing formation of blood vessels by differentiation of endothelial progenitor cells (EPCs). We investigated antifibrogenic and regenerative ...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-006-0311-1
更新日期:2006-03-01 00:00:00
abstract::Brush cells (BCs) are relatively rare cells that are sparsely distributed throughout the mammalian digestive and respiratory systems. BCs have been identified in the rodent large intestine, but these cells have not been characterized by immunocytochemistry or electron microscopy. We previously demonstrated that rat bi...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-008-0412-0
更新日期:2008-09-01 00:00:00
abstract::Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-019-00226-5
更新日期:2020-03-01 00:00:00
abstract::Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC1638T/1638T mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-020-00279-x
更新日期:2021-01-25 00:00:00
abstract::Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...
journal_title:Medical molecular morphology
pub_type: 临床试验,杂志文章
doi:10.1007/s00795-019-00218-5
更新日期:2019-12-01 00:00:00
abstract::Acetylation is a well-studied post-translational modification (PTM) of tubulin. Acetylated tubulin is present in the centrioles, primary cilia, and flagella, which contain long-lived stable microtubules. Tubulin acetylation plays an important role in cellular activities including cell polarity, cell migration, vesicle...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-020-00260-8
更新日期:2020-12-01 00:00:00
abstract::A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-006-0349-0
更新日期:2007-09-01 00:00:00
abstract::Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-014-0090-z
更新日期:2015-09-01 00:00:00
abstract::Uterine leiomyoma is the most common tumor in the female genital tract, although its pathogenesis remains unclear. Molecular analyses have demonstrated that each leiomyoma nodule is monoclonal and harbors various DNA abnormalities, suggesting that DNA damage in normal smooth muscle cells plays an important role in the...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-011-0562-3
更新日期:2012-12-01 00:00:00
abstract::Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0167-6
更新日期:2018-03-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-020-00252-8
更新日期:2020-09-01 00:00:00
abstract::Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinoge...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0156-9
更新日期:2017-09-01 00:00:00
abstract::Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-020-00255-5
更新日期:2020-05-15 00:00:00
abstract::Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-009-0475-6
更新日期:2010-03-01 00:00:00
abstract::Extra-gastrointestinal stromal tumors (E-GISTs) not associated with the alimentary tract in the pelvic cavity are extremely rare. We treated a 49-year-old Japanese man with such an E-GIST in the pelvic cavity who underwent an intrapelvic tumorectomy with a total prostatectomy and partial rectum resection. Gross examin...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-011-0568-x
更新日期:2012-06-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-018-0184-0
更新日期:2018-09-01 00:00:00
abstract::The Tian-Long (TL) compound is a water-soluble extract of six Chinese medicinal herbs. To explore its antitumor properties and the mechanism for activity in gynecological malignancies, the present studies were carried out using Ishikawa cells derived from uterine endometrial adenocarcinoma. Morphologically, cell death...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-008-0424-9
更新日期:2009-03-01 00:00:00
abstract::A few studies of the morphogenesis of human herpesvirus (HHV) 6 type A and B (HHV-6A, -6B) have been performed using neurogenic, lymphoid, or epithelial cells. When human MT-4 T-lymphotropic virus type I (HTLV-I)-producing lymphoid cells were coinfected with HHV-6B in vitro, viral-specific proteins were clearly detect...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-008-0413-z
更新日期:2008-12-01 00:00:00
abstract::Ameloblastoma (AB), which is the most common odontogenic tumor, may originate from the dental lamina remnants. The expression of CD56, which is a transmembrane molecule, is associated with neuroectodermal differentiation of the embryonal cells. The aim of this study was to evaluate the expression of CD56 in AB, in com...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-010-0510-7
更新日期:2011-06-01 00:00:00
abstract::We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular ...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-020-00244-8
更新日期:2020-09-01 00:00:00
abstract::IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-008-0425-8
更新日期:2009-12-01 00:00:00
abstract::The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth ret...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-016-0152-5
更新日期:2017-06-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-015-0095-2
更新日期:2016-09-01 00:00:00
abstract::In a case of metanephric adenoma of the kidney, many apical cytoplasmic blebs were found on the luminal surface of tumor cells. The tumor, measuring 15 mm in diameter, was found incidentally in the right kidney of a 40-year-old woman. It consisted of a dense proliferation of cuboidal cells forming small tubules of rou...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-015-0124-1
更新日期:2016-03-01 00:00:00
abstract::Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD. Biopsi...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-013-0015-2
更新日期:2013-09-01 00:00:00