Abstract:
:Progression of liver fibrosis has been linked with injuries associated with hypoxia and neovascularization. Neovascularization consists of angiogenesis and vasculogenesis, representing formation of blood vessels by differentiation of endothelial progenitor cells (EPCs). We investigated antifibrogenic and regenerative effects of EPC transplantation in chronic liver injury. Rat EPCs were isolated from bone marrow cells and examined in vitro for lineage markers. Recipient rats were injected intraperitoneally with dimethylnitrosamine (DMN) three times weekly for 4 weeks, plus EPC transplantation once weekly for 4 weeks. Transplanted rats showed suppression of liver fibrogenesis. Expression of growth factors promoting liver regeneration such as hepatocyte growth factor (HGF), transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) was increased in transplanted rats, together with hepatocyte proliferation. Normal liver function parameters such as transaminase, total bilirubin, total protein, and albumin were maintained in transplanted rats. EPC transplantation is effective not only for preventing liver fibrosis but also for promoting regeneration in chronically damaged livers. Also, recently it has been reported that green fluorescent protein-positive bone marrow cells contribute to the liver tissue repair of fibrosis model rats. EPC transplantation might become an alternative if further preclinical investigation finds it to be effective in severely cirrhotic livers.
journal_name
Med Mol Morpholjournal_title
Medical molecular morphologyauthors
Ueno T,Nakamura T,Torimura T,Sata Mdoi
10.1007/s00795-006-0311-1subject
Has Abstractpub_date
2006-03-01 00:00:00pages
16-21issue
1eissn
1860-1480issn
1860-1499journal_volume
39pub_type
杂志文章,评审abstract::We herein report a variant case of desmoplastic small round cell tumor (DSRCT) showing limited desmoplasia and confusing immunohistochemical findings. A 26-year-old male was referred for multiple abdominal masses. Laparoscopic biopsy showed only the solid proliferation of small round cells, and he was initially diagno...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-019-00242-5
更新日期:2020-09-01 00:00:00
abstract::In the present study, we investigated the changes in the localization of the glucose transporter GLUT2 and the fructose transporter GLUT5 in small intestinal absorptive cells during postnatal development, especially during the weaning period, using immunohistochemistry and confocal laser scanning microscopy. In the je...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-004-0275-y
更新日期:2005-03-01 00:00:00
abstract::The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0154-y
更新日期:2017-09-01 00:00:00
abstract::Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0155-x
更新日期:2017-09-01 00:00:00
abstract::A 73-year-old woman showed marked exophytic growth of a tumor (25 × 23 × 14 mm) of the nipple over a period of 2 months. Histologically, numerous tumor nodules with no apparent keratinization were observed in the exophytic lesion. The tumor cells also showed little invasion to the dermis and no metastasis to the axill...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-010-0520-5
更新日期:2011-09-01 00:00:00
abstract::We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectr...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-007-0378-3
更新日期:2007-12-01 00:00:00
abstract::DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-016-0144-5
更新日期:2017-03-01 00:00:00
abstract::A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-006-0349-0
更新日期:2007-09-01 00:00:00
abstract::Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferas...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-007-0386-3
更新日期:2008-03-01 00:00:00
abstract::Mass spectrometric analysis of glioblastoma cyst fluids has disclosed a protein peak with m/z 6424-6433. Among the proteins, potentially generating this peak are ApoC1 and LuzP6. To further elucidate protein expression of glioblastoma cells, we analyzed MALDI-TOF results of cyst fluid, performed immunohistochemistry a...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-019-00223-8
更新日期:2019-12-01 00:00:00
abstract::Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-008-0400-4
更新日期:2008-06-01 00:00:00
abstract::Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-018-0197-8
更新日期:2018-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most common primary cancer worldwide. The only current drug available for clinical treatment of HCC is sorafenib, which inhibits multiple signaling kinases including Raf family members, platelet-derived growth factor receptor, vascular endothelial growth factor receptors 1 and 2, ...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-011-0558-z
更新日期:2011-12-01 00:00:00
abstract::Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...
journal_title:Medical molecular morphology
pub_type: 临床试验,杂志文章
doi:10.1007/s00795-019-00218-5
更新日期:2019-12-01 00:00:00
abstract::Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinoge...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0156-9
更新日期:2017-09-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-020-00255-5
更新日期:2020-05-15 00:00:00
abstract::Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD. Biopsi...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-013-0015-2
更新日期:2013-09-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-020-00252-8
更新日期:2020-09-01 00:00:00
abstract::It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that th...
journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-013-0047-7
更新日期:2013-12-01 00:00:00
abstract::Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-004-0283-y
更新日期:2005-06-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-006-0340-9
更新日期:2006-12-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-006-0327-6
更新日期:2007-03-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-019-00226-5
更新日期:2020-03-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-017-0167-6
更新日期:2018-03-01 00:00:00
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journal_title:Medical molecular morphology
pub_type: 杂志文章,评审
doi:10.1007/s00795-010-0513-4
更新日期:2011-03-01 00:00:00
abstract::Vibrio cholerae colonizes the lumen of the proximal small intestine, which has an alkaline environment, and secretes cholera toxin (CT) through a type II secretion machinery. V. cholerae possesses the intrabacterial nanotransportation system (ibNoTS) for transporting CT from the inner portion toward the peripheral por...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-015-0105-4
更新日期:2015-12-01 00:00:00
abstract::Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patie...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-016-0150-7
更新日期:2017-06-01 00:00:00
abstract::Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-009-0475-6
更新日期:2010-03-01 00:00:00
abstract::Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...
journal_title:Medical molecular morphology
pub_type: 杂志文章
doi:10.1007/s00795-014-0090-z
更新日期:2015-09-01 00:00:00