Poorly differentiated squamous cell carcinoma of the nipple: a unique case for marked exophytic growth, but little invasion with neuroendocrine differentiation.

abstract：:The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were...

journal_title：Medical molecular morphology

authors： Shibata MA,Shibata E,Maemura K,Kondo Y,Harada-Shiba M

更新日期：2017-09-01 00:00:00

abstract：:Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...

journal_title：Medical molecular morphology

authors： Shimomura A,Takasaki A,Nomura R,Hayashi N,Senda T

更新日期：2013-03-01 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied...

journal_title：Medical molecular morphology

authors： Kanomata N,Yamaguchi R,Kurebayashi J,Moriya T

更新日期：2020-03-01 00:00:00

abstract：:Mass spectrometric analysis of glioblastoma cyst fluids has disclosed a protein peak with m/z 6424-6433. Among the proteins, potentially generating this peak are ApoC1 and LuzP6. To further elucidate protein expression of glioblastoma cells, we analyzed MALDI-TOF results of cyst fluid, performed immunohistochemistry a...

journal_title：Medical molecular morphology

authors： Evangelou P,Groll M,Oppermann H,Gaunitz F,Eisenlöffel C,Müller W,Eschrich K,Schänzer A,Nestler U

更新日期：2019-12-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth ret...

journal_title：Medical molecular morphology

authors： Wang T,Onouchi T,Yamada NO,Matsuda S,Senda T

更新日期：2017-06-01 00:00:00

abstract：:Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...

journal_title：Medical molecular morphology

authors： Tofrizal A,Fujiwara K,Azuma M,Kikuchi M,Jindatip D,Yashiro T,Yamada S

更新日期：2017-09-01 00:00:00

abstract：:Detachment of mesothelial cells is an early step in adhesion of the human pleura. To elucidate this process, we used adhesion molecules as the targets of primary antibody and performed immunohistochemical staining of the mesothelial cells that cover the surface of the sites of pleural adhesion and the macrophages that...

journal_title：Medical molecular morphology

authors： Amari M,Taguchi K,Iwahara M,Oharaseki T,Yokouchi Y,Naoe S,Takahashi K

更新日期：2006-12-01 00:00:00

abstract：:Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P...

journal_title：Medical molecular morphology

authors： Hyo Y,Yamada S,Ishimatsu M,Fukutsuji K,Harada T

更新日期：2012-06-01 00:00:00

abstract：:We examined the effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats. Three-week-old rats were kept on a diet containing either 12% protein (Lp rats) or 18% protein (Np rats) for 4 or 8 weeks after subtotal nephrectomy (SUNx). In Western blot analysi...

journal_title：Medical molecular morphology

authors： Mino M,Ihara H,Kozaki S,Kondo T,Takeshita A,Kusakabe KT,Okada T

更新日期：2010-06-01 00:00:00

abstract：:In the present study, we investigated the changes in the localization of the glucose transporter GLUT2 and the fructose transporter GLUT5 in small intestinal absorptive cells during postnatal development, especially during the weaning period, using immunohistochemistry and confocal laser scanning microscopy. In the je...

journal_title：Medical molecular morphology

authors： Baba R,Yamami M,Sakuma Y,Fujita M,Fujimoto S

更新日期：2005-03-01 00:00:00

abstract：:Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferas...

journal_title：Medical molecular morphology

authors： Shiraishi M,Doi Y,Kayashima K,Fujimoto S

更新日期：2008-03-01 00:00:00

abstract：:Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017...

journal_title：Medical molecular morphology

authors： Takahashi A,Ohira H,Abe K,Zeniya M,Abe M,Arinaga-Hino T,Torimura T,Yoshizawa K,Takaki A,Kang JH,Suzuki Y,Nakamoto N,Inui A,Tanaka A,Takikawa H

更新日期：2020-05-15 00:00:00

abstract：:Dusp22 (dual-specificity phosphatase 22) is considered to regulate various cellular processes through the regulation of protein dephosphorylation. In this study, we prepared a specific antibody against Dusp22, anti-Dusp22, and carried out expression analyses with mouse tissues and cultured cell lines. Western blotting...

journal_title：Medical molecular morphology

authors： Hamada N,Mizuno M,Tomita H,Iwamoto I,Hara A,Nagata KI

更新日期：2018-06-01 00:00:00

abstract：:Hair is one of the smallest organs, but has many important functions to mammals. Hair morphogenesis occurs through the reciprocal exchange of epithelial and mesenchymal signals. There are some reports about the expression of laminin-511 and -332 during hair morphogenesis, but are no reports of the chronological expres...

journal_title：Medical molecular morphology

authors： Imanishi H,Tsuruta D,Tateishi C,Sugawara K,Kobayashi H,Ishii M,Kishi K

更新日期：2014-03-01 00:00:00

abstract：:A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...

journal_title：Medical molecular morphology

authors： Kuroda N,Iwamura S,Fujishima N,Ohara M,Hirouchi T,Mizuno K,Hayashi Y,Lee GH

更新日期：2007-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary cancer worldwide. The only current drug available for clinical treatment of HCC is sorafenib, which inhibits multiple signaling kinases including Raf family members, platelet-derived growth factor receptor, vascular endothelial growth factor receptors 1 and 2, ...

journal_title：Medical molecular morphology

authors： Matsuda Y,Fukumoto M

更新日期：2011-12-01 00:00:00

abstract：:Helicobacter pylori possesses intrabacterial nanotransportation system (ibNoTS) for transporting CagA, VacA, and urease within the bacterial cytoplasm, which is controlled by the extrabacterial environment. The route of ibNoTS for CagA is reported to be associated with the MreB filament, whereas the route of ibNoTS fo...

journal_title：Medical molecular morphology

authors： Wu H,Iwai N,Suzuki Y,Nakano T

更新日期：2019-12-01 00:00:00

abstract：:Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC1638T/1638T mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they...

journal_title：Medical molecular morphology

authors： Wenduerma,Yamada NO,Wang T,Senda T

更新日期：2021-01-25 00:00:00

abstract：:In the human placenta, embryo-derived trophoblasts aggressively invade maternal spiral arteries and transform the arteries to low-resistance large-caliber vessels. This process, which ensures adequate placental perfusion, is called maternal vascular remodeling. Histological examination showed deposition of maternal pl...

journal_title：Medical molecular morphology

authors： Sato Y,Fujiwara H,Konishi I

更新日期：2010-09-01 00:00:00

abstract：:E-cadherin expression patterns in acinar cell carcinomas (ACCs) of the pancreas have not been well documented. Herein, we present a hitherto undescribed case of E-cadherin-negative ACC with a solid pseudopapillary growth pattern in a 65-year-old man. We used an antibody against the extracellular domain of E-cadherin. ...

journal_title：Medical molecular morphology

authors： Tajima S,Waki M,Azuma M,Koda K,Ohata A

更新日期：2016-09-01 00:00:00

abstract：:We herein report a variant case of desmoplastic small round cell tumor (DSRCT) showing limited desmoplasia and confusing immunohistochemical findings. A 26-year-old male was referred for multiple abdominal masses. Laparoscopic biopsy showed only the solid proliferation of small round cells, and he was initially diagno...

journal_title：Medical molecular morphology

authors： Kihara A,Takahashi K,Ishikawa A,Amano Y,Matsubara D,Kanda H,Sata N,Fukushima N,Niki T

更新日期：2020-09-01 00:00:00

abstract：:Malignant müllerian mixed tumors (MMMTs) of the fallopian tube are very rare neoplasms, and we present such a case with unusual findings here. A 57-year-old Japanese woman, after she received a medical checkup, underwent salpingo-oophorectomy on the suspicion of ovarian cancer. At the time of operation, the main tumor...

journal_title：Medical molecular morphology

authors： Kuroda N,Inui Y,Ohara M,Hirouchi T,Mizuno K,Kubo A,Hayashi Y,Enzan H,Lee GH

更新日期：2007-03-01 00:00:00

abstract：:Non-invasive predictors for the development of cirrhosis-related conditions are needed for patients with primary biliary cholangitis (PBC). We investigated the association between cytokeratin-18 fragments (M30 and M65) and liver histology, treatment response and the development of cirrhosis-related conditions in patie...

journal_title：Medical molecular morphology

authors： Hayashi M,Abe K,Fujita M,Okai K,Takahashi A,Nozawa Y,Ohira H

更新日期：2018-09-01 00:00:00

abstract：:Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patie...

journal_title：Medical molecular morphology

authors： Hao H,Xia G,Wang C,Zhong F,Liu L,Zhang D

更新日期：2017-06-01 00:00:00

abstract：:Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently described. To date, there are no reports on genetic findings of G-band karyotype of ACD-associated RCC. In this article, we report the first report of G-band karyotype of ACD-associated RCC. A 66-year-old Japanese man was found to ha...

journal_title：Medical molecular morphology

authors： Kuroda N,Shiotsu T,Hes O,Michal M,Shuin T,Lee GH

更新日期：2010-12-01 00:00:00

abstract：:Uterine leiomyoma is the most common tumor in the female genital tract, although its pathogenesis remains unclear. Molecular analyses have demonstrated that each leiomyoma nodule is monoclonal and harbors various DNA abnormalities, suggesting that DNA damage in normal smooth muscle cells plays an important role in the...

journal_title：Medical molecular morphology

authors： Suzuki A,Kariya M,Matsumura N,Baba T,Yagi H,Mandai M,Konishi I,Fujii S

更新日期：2012-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...

journal_title：Medical molecular morphology

authors： Tamaru S,Kajihara T,Mizuno Y,Mizuno Y,Tochigi H,Ishihara O

更新日期：2020-09-01 00:00:00

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...

journal_title：Medical molecular morphology

authors： Hori M,Someya M,Matsumoto Y,Nakata K,Kitagawa M,Hasegawa T,Tsuchiya T,Fukushima Y,Gocho T,Sato Y,Ohnuma H,Kato J,Sugita S,Hasegawa T,Sakata KI

更新日期：2017-03-01 00:00:00