Abstract:
:Helicobacter pylori possesses intrabacterial nanotransportation system (ibNoTS) for transporting CagA, VacA, and urease within the bacterial cytoplasm, which is controlled by the extrabacterial environment. The route of ibNoTS for CagA is reported to be associated with the MreB filament, whereas the route of ibNoTS for urease is not yet known. In this study, we demonstrated by immunoelectron microscopy that urease along the route of ibNoTS localizes closely with the FtsZ filament in the bacterium. Supporting this, we found by enzyme immunoassay and co-immunoprecipitation analysis that urease interacted with FtsZ. These findings indicate that urease along the route of ibNoTS is closely associated with the FtsZ filament. Since these phenomena were not observed in ibNoTS for CagA, the route of ibNoTS for CagA is different from that of ibNoTS for urease. We propose that the route of ibNoTS for urease is associated with the FtsZ filament in H. pylori.
journal_name
Med Mol Morpholjournal_title
Medical molecular morphologyauthors
Wu H,Iwai N,Suzuki Y,Nakano Tdoi
10.1007/s00795-019-00225-6subject
Has Abstractpub_date
2019-12-01 00:00:00pages
226-234issue
4eissn
1860-1480issn
1860-1499pii
10.1007/s00795-019-00225-6journal_volume
52pub_type
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