A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...

journal_title：Medical molecular morphology

authors： Tamaru S,Kajihara T,Mizuno Y,Mizuno Y,Tochigi H,Ishihara O

更新日期：2020-09-01 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were...

journal_title：Medical molecular morphology

authors： Shibata MA,Shibata E,Maemura K,Kondo Y,Harada-Shiba M

更新日期：2017-09-01 00:00:00

abstract：:Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...

journal_title：Medical molecular morphology

authors： Shimomura A,Takasaki A,Nomura R,Hayashi N,Senda T

更新日期：2013-03-01 00:00:00

abstract：:Experimental pressure ulcers were successfully produced in the rat abdominal wall at 100 mmHg in our previous study. We hypothesized that injury is less severe when pressures are lower than 100 mmHg and explored a critical pressure in the production of pressure ulcers. At 70 and 60 mmHg, repeated compressions for 4 h ...

journal_title：Medical molecular morphology

authors： Kawamata S,Kurose T,Kubori Y,Muramoto H,Honkawa Y

更新日期：2015-03-01 00:00:00

abstract：:E-cadherin expression patterns in acinar cell carcinomas (ACCs) of the pancreas have not been well documented. Herein, we present a hitherto undescribed case of E-cadherin-negative ACC with a solid pseudopapillary growth pattern in a 65-year-old man. We used an antibody against the extracellular domain of E-cadherin. ...

journal_title：Medical molecular morphology

authors： Tajima S,Waki M,Azuma M,Koda K,Ohata A

更新日期：2016-09-01 00:00:00

abstract：:DNA double-strand break (DSB) is one of the most serious forms of damage induced by ionizing irradiation and is mainly repaired by the non-homologous end joining (NHEJ) repair. Immunohistochemical analysis of proteins involved in NHEJ, such as XRCC4 (X-ray repair cross-complementing protein 4), Ku86 and DNA-PKcs (DNA-...

journal_title：Medical molecular morphology

authors： Hori M,Someya M,Matsumoto Y,Nakata K,Kitagawa M,Hasegawa T,Tsuchiya T,Fukushima Y,Gocho T,Sato Y,Ohnuma H,Kato J,Sugita S,Hasegawa T,Sakata KI

更新日期：2017-03-01 00:00:00

abstract：:Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD. Biopsi...

journal_title：Medical molecular morphology

authors： Hayashi H,Hattori A,Tatsumi Y,Hayashi K,Katano Y,Ueyama J,Wakusawa S,Yano M,Goto H

更新日期：2013-09-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...

journal_title：Medical molecular morphology

authors： Tanigawa M,Nakayama M,Taira T,Hattori S,Mihara Y,Kondo R,Kusano H,Nakamura K,Abe Y,Ishida Y,Okabe Y,Hisaka T,Okuda K,Fujino K,Ito T,Kawahara A,Naito Y,Yamaguchi R,Akiba J,Akagi Y,Yano H

更新日期：2018-03-01 00:00:00

abstract：:Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently described. To date, there are no reports on genetic findings of G-band karyotype of ACD-associated RCC. In this article, we report the first report of G-band karyotype of ACD-associated RCC. A 66-year-old Japanese man was found to ha...

journal_title：Medical molecular morphology

authors： Kuroda N,Shiotsu T,Hes O,Michal M,Shuin T,Lee GH

更新日期：2010-12-01 00:00:00

abstract：:Desquamation in the mammalian skin is a well-balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein ...

journal_title：Medical molecular morphology

authors： Ishida-Yamamoto A,Kishibe M

更新日期：2011-03-01 00:00:00

abstract：:Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinoge...

journal_title：Medical molecular morphology

authors： Adhikari BR,Uehara O,Matsuoka H,Takai R,Harada F,Utsunomiya M,Chujo T,Morikawa T,Shakya M,Yoshida K,Sato J,Arakawa T,Nishimura M,Nagayasu H,Chiba I,Abiko Y

更新日期：2017-09-01 00:00:00

abstract：:ArgBP2 is a member of the SoHo (sorbin-homology) family of adaptor proteins believed to play roles in cell adhesion, cytoskeletal organization, and signaling. We show here a novel splicing isoform of ArgBP2, i.e., ArgBP2™, composed of only three SH3 (src-homology 3) domains and structurally similar to vinexinß. We the...

journal_title：Medical molecular morphology

authors： Murase K,Ito H,Kanoh H,Sudo K,Iwamoto I,Morishita R,Soubeyran P,Seishima M,Nagata K

更新日期：2012-12-01 00:00:00

abstract：:It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that th...

journal_title：Medical molecular morphology

authors： Matsuda Y,Wakai T,Kubota M,Takamura M,Yamagiwa S,Aoyagi Y,Osawa M,Fujimaki S,Sanpei A,Genda T,Ichida T

更新日期：2013-12-01 00:00:00

abstract：:Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...

journal_title：Medical molecular morphology

authors： Sakaue T,Koga H,Iwamoto H,Nakamura T,Ikezono Y,Abe M,Wada F,Masuda A,Tanaka T,Fukahori M,Ushijima T,Mihara Y,Naitou Y,Okabe Y,Kakuma T,Ohta K,Nakamura KI,Torimura T

更新日期：2019-12-01 00:00:00

abstract：:Acetylation is a well-studied post-translational modification (PTM) of tubulin. Acetylated tubulin is present in the centrioles, primary cilia, and flagella, which contain long-lived stable microtubules. Tubulin acetylation plays an important role in cellular activities including cell polarity, cell migration, vesicle...

journal_title：Medical molecular morphology

authors： Nekooki-Machida Y,Hagiwara H

更新日期：2020-12-01 00:00:00

abstract：:We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectr...

journal_title：Medical molecular morphology

authors： Shimasaki N,Kuroda N,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H,Shuin T

更新日期：2007-12-01 00:00:00

abstract：:Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...

journal_title：Medical molecular morphology

authors： Tofrizal A,Fujiwara K,Azuma M,Kikuchi M,Jindatip D,Yashiro T,Yamada S

更新日期：2017-09-01 00:00:00

abstract：:Fibrates belong to a group of ligands of peroxisome proliferator-activated receptor alpha (PPARα), which play a role in the regulation of CYP epoxygenases and soluble epoxide hydrolase (sEH), key enzymes in the metabolism of biologically highly active epoxyeicosatrienoic acids (EETs). We demonstrated that low doses of...

journal_title：Medical molecular morphology

authors： Tauber Z,Koleckova M,Cizkova K

更新日期：2020-09-01 00:00:00

abstract：:We examined the effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats. Three-week-old rats were kept on a diet containing either 12% protein (Lp rats) or 18% protein (Np rats) for 4 or 8 weeks after subtotal nephrectomy (SUNx). In Western blot analysi...

journal_title：Medical molecular morphology

authors： Mino M,Ihara H,Kozaki S,Kondo T,Takeshita A,Kusakabe KT,Okada T

更新日期：2010-06-01 00:00:00

abstract：:In the human placenta, embryo-derived trophoblasts aggressively invade maternal spiral arteries and transform the arteries to low-resistance large-caliber vessels. This process, which ensures adequate placental perfusion, is called maternal vascular remodeling. Histological examination showed deposition of maternal pl...

journal_title：Medical molecular morphology

authors： Sato Y,Fujiwara H,Konishi I

更新日期：2010-09-01 00:00:00

abstract：:The Tian-Long (TL) compound is a water-soluble extract of six Chinese medicinal herbs. To explore its antitumor properties and the mechanism for activity in gynecological malignancies, the present studies were carried out using Ishikawa cells derived from uterine endometrial adenocarcinoma. Morphologically, cell death...

journal_title：Medical molecular morphology

authors： Li ZL,Morishima S,Tang JT,Otsuki Y

更新日期：2009-03-01 00:00:00

abstract：:To evaluate the peculiar "inside-out" pattern in micropapillary (MP) carcinoma, we investigated the usefulness of KL-6 antibody in the assessment of the MP pattern of cancers, in comparison with antibodies to epithelial membrane antigen (EMA), MUC1 (CD227), and CD 10. Immunohistochemical investigation was performed on...

journal_title：Medical molecular morphology

authors： Ohtsuki Y,Kuroda N,Umeoka T,Watanabe R,Ochi K,Okada Y,Lee GH,Furihata M

更新日期：2009-06-01 00:00:00

abstract：:Non-invasive predictors for the development of cirrhosis-related conditions are needed for patients with primary biliary cholangitis (PBC). We investigated the association between cytokeratin-18 fragments (M30 and M65) and liver histology, treatment response and the development of cirrhosis-related conditions in patie...

journal_title：Medical molecular morphology

authors： Hayashi M,Abe K,Fujita M,Okai K,Takahashi A,Nozawa Y,Ohira H

更新日期：2018-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary cancer worldwide. The only current drug available for clinical treatment of HCC is sorafenib, which inhibits multiple signaling kinases including Raf family members, platelet-derived growth factor receptor, vascular endothelial growth factor receptors 1 and 2, ...

journal_title：Medical molecular morphology

authors： Matsuda Y,Fukumoto M

更新日期：2011-12-01 00:00:00

abstract：:The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...

journal_title：Medical molecular morphology

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2015-09-01 00:00:00

abstract：:Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...

journal_title：Medical molecular morphology

authors： Omote S,Takata K,Tanaka T,Miyata-Takata T,Ayada Y,Noujima-Harada M,Omote R,Tabata T,Sato Y,Toyokawa T,Kato H,Yagi T,Okada H,Yoshino T

更新日期：2018-12-01 00:00:00

abstract：:Dusp22 (dual-specificity phosphatase 22) is considered to regulate various cellular processes through the regulation of protein dephosphorylation. In this study, we prepared a specific antibody against Dusp22, anti-Dusp22, and carried out expression analyses with mouse tissues and cultured cell lines. Western blotting...

journal_title：Medical molecular morphology

authors： Hamada N,Mizuno M,Tomita H,Iwamoto I,Hara A,Nagata KI

更新日期：2018-06-01 00:00:00

abstract：:Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patie...

journal_title：Medical molecular morphology

authors： Hao H,Xia G,Wang C,Zhong F,Liu L,Zhang D

更新日期：2017-06-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth ret...

journal_title：Medical molecular morphology

authors： Wang T,Onouchi T,Yamada NO,Matsuda S,Senda T

更新日期：2017-06-01 00:00:00