Abstract:
:MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regulate various pathological conditions such as tumors, metastases, metabolic diseases, and osteoporosis. Although several studies have been performed on miRNAs, only few studies have described the miRNA expression and functions in human reproductive tract tissues. During menstruation, the human endometrium undergoes extensive cyclic morphological and biochemical modifications before embryo implantation. In addition to the ovarian steroid hormones (estrogen and progesterone), endometrial autocrine or paracrine factors and embryo-derived signals play a significant role in endometrial functions. miRNAs are considered key regulators of gene expression in the human endometrium and implantation process, and their aberrant expression levels are associated with the development of various disorders, including tumorigenesis. In this review, we summarize the studies that show the role of miRNAs in regulating the physiological conditions of the endometrium and the implantation process and discuss the aberrant expression of miRNAs in ectopic pregnancy, endometriosis, and endometrial cancer.
journal_name
Med Mol Morpholjournal_title
Medical molecular morphologyauthors
Tamaru S,Kajihara T,Mizuno Y,Mizuno Y,Tochigi H,Ishihara Odoi
10.1007/s00795-020-00252-8subject
Has Abstractpub_date
2020-09-01 00:00:00pages
131-140issue
3eissn
1860-1480issn
1860-1499pii
10.1007/s00795-020-00252-8journal_volume
53pub_type
杂志文章,评审abstract::The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...
journal_title:Medical molecular morphology
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journal_title:Medical molecular morphology
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journal_title:Medical molecular morphology
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journal_title:Medical molecular morphology
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