Peroxisome proliferator-activated receptor ɑ (PPARɑ)-cytochrome P450 epoxygenases-soluble epoxide hydrolase axis in ER + PR + HER2- breast cancer.

abstract：:Detachment of mesothelial cells is an early step in adhesion of the human pleura. To elucidate this process, we used adhesion molecules as the targets of primary antibody and performed immunohistochemical staining of the mesothelial cells that cover the surface of the sites of pleural adhesion and the macrophages that...

journal_title：Medical molecular morphology

authors： Amari M,Taguchi K,Iwahara M,Oharaseki T,Yokouchi Y,Naoe S,Takahashi K

更新日期：2006-12-01 00:00:00

abstract：:Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied...

journal_title：Medical molecular morphology

authors： Kanomata N,Yamaguchi R,Kurebayashi J,Moriya T

更新日期：2020-03-01 00:00:00

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017...

journal_title：Medical molecular morphology

authors： Takahashi A,Ohira H,Abe K,Zeniya M,Abe M,Arinaga-Hino T,Torimura T,Yoshizawa K,Takaki A,Kang JH,Suzuki Y,Nakamoto N,Inui A,Tanaka A,Takikawa H

更新日期：2020-05-15 00:00:00

abstract：:Uterine leiomyoma is the most common tumor in the female genital tract, although its pathogenesis remains unclear. Molecular analyses have demonstrated that each leiomyoma nodule is monoclonal and harbors various DNA abnormalities, suggesting that DNA damage in normal smooth muscle cells plays an important role in the...

journal_title：Medical molecular morphology

authors： Suzuki A,Kariya M,Matsumura N,Baba T,Yagi H,Mandai M,Konishi I,Fujii S

更新日期：2012-12-01 00:00:00

abstract：:We examined the effects of low protein intake on the development of the remaining kidney in subtotally (5/6) nephrectomized immature rats. Three-week-old rats were kept on a diet containing either 12% protein (Lp rats) or 18% protein (Np rats) for 4 or 8 weeks after subtotal nephrectomy (SUNx). In Western blot analysi...

journal_title：Medical molecular morphology

authors： Mino M,Ihara H,Kozaki S,Kondo T,Takeshita A,Kusakabe KT,Okada T

更新日期：2010-06-01 00:00:00

abstract：:Progression of liver fibrosis has been linked with injuries associated with hypoxia and neovascularization. Neovascularization consists of angiogenesis and vasculogenesis, representing formation of blood vessels by differentiation of endothelial progenitor cells (EPCs). We investigated antifibrogenic and regenerative ...

journal_title：Medical molecular morphology

authors： Ueno T,Nakamura T,Torimura T,Sata M

更新日期：2006-03-01 00:00:00

abstract：:A few studies of the morphogenesis of human herpesvirus (HHV) 6 type A and B (HHV-6A, -6B) have been performed using neurogenic, lymphoid, or epithelial cells. When human MT-4 T-lymphotropic virus type I (HTLV-I)-producing lymphoid cells were coinfected with HHV-6B in vitro, viral-specific proteins were clearly detect...

journal_title：Medical molecular morphology

authors： Ohtsuki Y,Daibata M,Bandobashi K,Lee GH,Furihata M,Yokoyama A,Miyoshi I

更新日期：2008-12-01 00:00:00

abstract：:In a case of metanephric adenoma of the kidney, many apical cytoplasmic blebs were found on the luminal surface of tumor cells. The tumor, measuring 15 mm in diameter, was found incidentally in the right kidney of a 40-year-old woman. It consisted of a dense proliferation of cuboidal cells forming small tubules of rou...

journal_title：Medical molecular morphology

authors： Shintaku M,Maeno K

更新日期：2016-03-01 00:00:00

abstract：:Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. We demonstrated that Burow's solution had antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa, inducing ultrastructural changes in these bacteria in vitro. S. aureus strain 209P and P...

journal_title：Medical molecular morphology

authors： Hyo Y,Yamada S,Ishimatsu M,Fukutsuji K,Harada T

更新日期：2012-06-01 00:00:00

abstract：:Mass spectrometric analysis of glioblastoma cyst fluids has disclosed a protein peak with m/z 6424-6433. Among the proteins, potentially generating this peak are ApoC1 and LuzP6. To further elucidate protein expression of glioblastoma cells, we analyzed MALDI-TOF results of cyst fluid, performed immunohistochemistry a...

journal_title：Medical molecular morphology

authors： Evangelou P,Groll M,Oppermann H,Gaunitz F,Eisenlöffel C,Müller W,Eschrich K,Schänzer A,Nestler U

更新日期：2019-12-01 00:00:00

abstract：:Vibrio cholerae colonizes the lumen of the proximal small intestine, which has an alkaline environment, and secretes cholera toxin (CT) through a type II secretion machinery. V. cholerae possesses the intrabacterial nanotransportation system (ibNoTS) for transporting CT from the inner portion toward the peripheral por...

journal_title：Medical molecular morphology

authors： Matsuzaki Y,Wu H,Nakano T,Nakahari T,Sano K

更新日期：2015-12-01 00:00:00

abstract：:Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pa...

journal_title：Medical molecular morphology

authors： Omote S,Takata K,Tanaka T,Miyata-Takata T,Ayada Y,Noujima-Harada M,Omote R,Tabata T,Sato Y,Toyokawa T,Kato H,Yagi T,Okada H,Yoshino T

更新日期：2018-12-01 00:00:00

abstract：:Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC1638T/1638T mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they...

journal_title：Medical molecular morphology

authors： Wenduerma,Yamada NO,Wang T,Senda T

更新日期：2021-01-25 00:00:00

abstract：:Helicobacter pylori possesses intrabacterial nanotransportation system (ibNoTS) for transporting CagA, VacA, and urease within the bacterial cytoplasm, which is controlled by the extrabacterial environment. The route of ibNoTS for CagA is reported to be associated with the MreB filament, whereas the route of ibNoTS fo...

journal_title：Medical molecular morphology

authors： Wu H,Iwai N,Suzuki Y,Nakano T

更新日期：2019-12-01 00:00:00

abstract：:Carcinoma follows a course of multiple changes that are affected by several important factors, with epigenetic silencing of the promoter gene being one of them. A series of studies have suggested that epigenetic changes in the anti-aging gene Klotho may be one of the emerging areas of concern in the study of carcinoge...

journal_title：Medical molecular morphology

authors： Adhikari BR,Uehara O,Matsuoka H,Takai R,Harada F,Utsunomiya M,Chujo T,Morikawa T,Shakya M,Yoshida K,Sato J,Arakawa T,Nishimura M,Nagayasu H,Chiba I,Abiko Y

更新日期：2017-09-01 00:00:00

abstract：:Cancer cells surviving in ascites exhibit cancer stem cell (CSC)-like features. This study analyzed the expression of the CSC marker CD133 in the ascites-derived exosomes obtained from patients with unresectable pancreatic cancer. In addition, inverse correlation of CD133 expression with prognosis was examined. Of the...

journal_title：Medical molecular morphology

authors： Sakaue T,Koga H,Iwamoto H,Nakamura T,Ikezono Y,Abe M,Wada F,Masuda A,Tanaka T,Fukahori M,Ushijima T,Mihara Y,Naitou Y,Okabe Y,Kakuma T,Ohta K,Nakamura KI,Torimura T

更新日期：2019-12-01 00:00:00

abstract：:Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patie...

journal_title：Medical molecular morphology

authors： Hao H,Xia G,Wang C,Zhong F,Liu L,Zhang D

更新日期：2017-06-01 00:00:00

abstract：:It is well accepted that cell cycle regulators are strongly implicated in the progression of cancer development. p16 and p27 are potent cyclin-dependent kinase (CDK) inhibitors involved in G1 phase progression, and are regarded as adverse prognostic biomarkers for various types of cancers. It has been reported that th...

journal_title：Medical molecular morphology

authors： Matsuda Y,Wakai T,Kubota M,Takamura M,Yamagiwa S,Aoyagi Y,Osawa M,Fujimaki S,Sanpei A,Genda T,Ichida T

更新日期：2013-12-01 00:00:00

abstract：:Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently described. To date, there are no reports on genetic findings of G-band karyotype of ACD-associated RCC. In this article, we report the first report of G-band karyotype of ACD-associated RCC. A 66-year-old Japanese man was found to ha...

journal_title：Medical molecular morphology

authors： Kuroda N,Shiotsu T,Hes O,Michal M,Shuin T,Lee GH

更新日期：2010-12-01 00:00:00

abstract：:Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...

journal_title：Medical molecular morphology

authors： Yokomori H,Oda M,Yoshimura K,Watanabe S,Hibi T

更新日期：2010-03-01 00:00:00

abstract：:IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...

journal_title：Medical molecular morphology

authors： Kuroda N,Nakamura S,Miyazaki K,Inoue K,Ohara M,Mizuno K,Sato Y,Yoshino T

更新日期：2009-12-01 00:00:00

abstract：:Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belo...

journal_title：Medical molecular morphology

authors： Matsuo Y,Tashiro H,Yanai H,Moriya T,Katabuchi H

更新日期：2015-09-01 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary cancer worldwide. The only current drug available for clinical treatment of HCC is sorafenib, which inhibits multiple signaling kinases including Raf family members, platelet-derived growth factor receptor, vascular endothelial growth factor receptors 1 and 2, ...

journal_title：Medical molecular morphology

authors： Matsuda Y,Fukumoto M

更新日期：2011-12-01 00:00:00

abstract：:ArgBP2 is a member of the SoHo (sorbin-homology) family of adaptor proteins believed to play roles in cell adhesion, cytoskeletal organization, and signaling. We show here a novel splicing isoform of ArgBP2, i.e., ArgBP2™, composed of only three SH3 (src-homology 3) domains and structurally similar to vinexinß. We the...

journal_title：Medical molecular morphology

authors： Murase K,Ito H,Kanoh H,Sudo K,Iwamoto I,Morishita R,Soubeyran P,Seishima M,Nagata K

更新日期：2012-12-01 00:00:00

abstract：:Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferas...

journal_title：Medical molecular morphology

authors： Shiraishi M,Doi Y,Kayashima K,Fujimoto S

更新日期：2008-03-01 00:00:00

abstract：:Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...

journal_title：Medical molecular morphology

authors： Shimomura A,Takasaki A,Nomura R,Hayashi N,Senda T

更新日期：2013-03-01 00:00:00

abstract：:Renal fibrosis is characterized by tubular cell atrophy and accumulation of extracellular matrix. Fibroblast activation becomes evident in areas surrounding atrophic tubules, with rarefaction of peritubular capillaries. Tubulointerstitial hypoxia is the final common pathway in progressive kidney disease. Hypoxia suppr...

journal_title：Medical molecular morphology

authors： Tanaka T

更新日期：2017-03-01 00:00:00

abstract：:Prolactinomas are the most common tumor of the human pituitary. They result in excessive prolactin secretion and important changes in the vasculature. Pericytes are perivascular cells associated with capillaries and have crucial roles in physiological and pathological neovascularization. We previously reported that pe...

journal_title：Medical molecular morphology

authors： Jindatip D,Fujiwara K,Sarachana T,Mutirangura A,Yashiro T

更新日期：2018-09-01 00:00:00