Prominent apical cytoplasmic bleb formation in metanephric adenoma: report of a case.

abstract：:The Tian-Long (TL) compound is a water-soluble extract of six Chinese medicinal herbs. To explore its antitumor properties and the mechanism for activity in gynecological malignancies, the present studies were carried out using Ishikawa cells derived from uterine endometrial adenocarcinoma. Morphologically, cell death...

journal_title：Medical molecular morphology

authors： Li ZL,Morishima S,Tang JT,Otsuki Y

更新日期：2009-03-01 00:00:00

abstract：:The present study was conducted to address the molecular pathogenesis underlying the progression of basal cell carcinoma (BCC) in a nevoid basal cell carcinoma syndrome (NBCCS) patient. We analyzed infiltrative BCCs that invaded the subcutaneous tissue of the scalp and penetrated the skull in a 61-year-old Japanese fe...

journal_title：Medical molecular morphology

authors： Tate G,Kishimoto K,Mitsuya T

更新日期：2015-09-01 00:00:00

abstract：:Extracellular matrix (ECM) is essential in tissue physiology and pathologic conditions such as tumorigenesis. It affects tumor cell behavior, proliferation, and metastasis. Pituitary adenomas differ in their clinical characteristics, including ECM deposition, and we recently reported that the characteristics of collag...

journal_title：Medical molecular morphology

authors： Tofrizal A,Fujiwara K,Azuma M,Kikuchi M,Jindatip D,Yashiro T,Yamada S

更新日期：2017-09-01 00:00:00

abstract：:The normal mammary gland can be roughly divided into the large duct close to the nipple and the terminal duct located within the lobulus. Both the large duct and the terminal duct are composed of epithelial cells and myoepithelial cells. The epithelial cells can be divided into light and dark cells using electron dens...

journal_title：Medical molecular morphology

authors： Tsuchiya S,Li F

更新日期：2005-12-01 00:00:00

abstract：:ArgBP2 is a member of the SoHo (sorbin-homology) family of adaptor proteins believed to play roles in cell adhesion, cytoskeletal organization, and signaling. We show here a novel splicing isoform of ArgBP2, i.e., ArgBP2™, composed of only three SH3 (src-homology 3) domains and structurally similar to vinexinß. We the...

journal_title：Medical molecular morphology

authors： Murase K,Ito H,Kanoh H,Sudo K,Iwamoto I,Morishita R,Soubeyran P,Seishima M,Nagata K

更新日期：2012-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They play fundamental roles in several biological processes, including cell differentiation and proliferation, embryo development, organ development, and organ metabolism. Besides regulating the physiological processes, miRNAs regula...

journal_title：Medical molecular morphology

authors： Tamaru S,Kajihara T,Mizuno Y,Mizuno Y,Tochigi H,Ishihara O

更新日期：2020-09-01 00:00:00

abstract：:Non-invasive predictors for the development of cirrhosis-related conditions are needed for patients with primary biliary cholangitis (PBC). We investigated the association between cytokeratin-18 fragments (M30 and M65) and liver histology, treatment response and the development of cirrhosis-related conditions in patie...

journal_title：Medical molecular morphology

authors： Hayashi M,Abe K,Fujita M,Okai K,Takahashi A,Nozawa Y,Ohira H

更新日期：2018-09-01 00:00:00

abstract：:We studied the distribution of myofibroblasts in the stroma of normal seminal vesicles. Twelve normal seminal vesicles obtained by surgery on the diagnosis of some diseases were selected, and we evaluated the distribution of myofibroblasts in the seminal vesicles using immunohistochemical and electron and immunoelectr...

journal_title：Medical molecular morphology

authors： Shimasaki N,Kuroda N,Miyazaki E,Hayashi Y,Toi M,Hiroi M,Enzan H,Shuin T

更新日期：2007-12-01 00:00:00

abstract：:Our study was designed to clarify the role of antioxidant enzymes in the rat von Ebner gland during acute nickel toxicity. After treatment with nickel acetate, we monitored ultrastructural alterations in acinar and ductal cells, immunohistochemical staining for glutathione peroxidase (GPx) and glutathione S-transferas...

journal_title：Medical molecular morphology

authors： Shiraishi M,Doi Y,Kayashima K,Fujimoto S

更新日期：2008-03-01 00:00:00

abstract：:Prolactinomas are the most common tumor of the human pituitary. They result in excessive prolactin secretion and important changes in the vasculature. Pericytes are perivascular cells associated with capillaries and have crucial roles in physiological and pathological neovascularization. We previously reported that pe...

journal_title：Medical molecular morphology

authors： Jindatip D,Fujiwara K,Sarachana T,Mutirangura A,Yashiro T

更新日期：2018-09-01 00:00:00

abstract：:A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and ...

journal_title：Medical molecular morphology

authors： Kuroda N,Iwamura S,Fujishima N,Ohara M,Hirouchi T,Mizuno K,Hayashi Y,Lee GH

更新日期：2007-09-01 00:00:00

abstract：:Almost every cell in our organism releases proteins and other biological substances using a fundamental cellular process known as constitutive exocytosis. In contrast, in exocrine and endocrine glands, the cells are inherent in an additional and more refined release mechanism directly tuned by extracellular signals. T...

journal_title：Medical molecular morphology

authors： Tsuboi T

更新日期：2008-06-01 00:00:00

abstract：:To evaluate the peculiar "inside-out" pattern in micropapillary (MP) carcinoma, we investigated the usefulness of KL-6 antibody in the assessment of the MP pattern of cancers, in comparison with antibodies to epithelial membrane antigen (EMA), MUC1 (CD227), and CD 10. Immunohistochemical investigation was performed on...

journal_title：Medical molecular morphology

authors： Ohtsuki Y,Kuroda N,Umeoka T,Watanabe R,Ochi K,Okada Y,Lee GH,Furihata M

更新日期：2009-06-01 00:00:00

abstract：:We report herein the microstructure of the acetabular labrum obtained from a patient with stem loosening but without bipolar cup migration who had undergone hemiarthroplasty for femoral neck fracture 18 years ago. We used light and scanning electron microscopy to investigate the influence of bipolar cup on acetabular ...

journal_title：Medical molecular morphology

authors： Kaku N,Shimada T,Nogami R,Tagomori H,Tsumura H

更新日期：2020-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary cancer worldwide. The only current drug available for clinical treatment of HCC is sorafenib, which inhibits multiple signaling kinases including Raf family members, platelet-derived growth factor receptor, vascular endothelial growth factor receptors 1 and 2, ...

journal_title：Medical molecular morphology

authors： Matsuda Y,Fukumoto M

更新日期：2011-12-01 00:00:00

abstract：:IgG4-related disease has been recently described. This disease occurs in various anatomic locations including pancreas, biliary tract, liver, retroperitoneum, kidney, breast, lung, thyroid gland, prostate, salivary gland, lacrimal gland, and lymph node. In this article, we report the first case of IgG4-related disease...

journal_title：Medical molecular morphology

authors： Kuroda N,Nakamura S,Miyazaki K,Inoue K,Ohara M,Mizuno K,Sato Y,Yoshino T

更新日期：2009-12-01 00:00:00

abstract：:Progression of liver fibrosis has been linked with injuries associated with hypoxia and neovascularization. Neovascularization consists of angiogenesis and vasculogenesis, representing formation of blood vessels by differentiation of endothelial progenitor cells (EPCs). We investigated antifibrogenic and regenerative ...

journal_title：Medical molecular morphology

authors： Ueno T,Nakamura T,Torimura T,Sata M

更新日期：2006-03-01 00:00:00

abstract：:The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were...

journal_title：Medical molecular morphology

authors： Shibata MA,Shibata E,Maemura K,Kondo Y,Harada-Shiba M

更新日期：2017-09-01 00:00:00

abstract：:Hair is one of the smallest organs, but has many important functions to mammals. Hair morphogenesis occurs through the reciprocal exchange of epithelial and mesenchymal signals. There are some reports about the expression of laminin-511 and -332 during hair morphogenesis, but are no reports of the chronological expres...

journal_title：Medical molecular morphology

authors： Imanishi H,Tsuruta D,Tateishi C,Sugawara K,Kobayashi H,Ishii M,Kishi K

更新日期：2014-03-01 00:00:00

abstract：:Fibrates belong to a group of ligands of peroxisome proliferator-activated receptor alpha (PPARα), which play a role in the regulation of CYP epoxygenases and soluble epoxide hydrolase (sEH), key enzymes in the metabolism of biologically highly active epoxyeicosatrienoic acids (EETs). We demonstrated that low doses of...

journal_title：Medical molecular morphology

authors： Tauber Z,Koleckova M,Cizkova K

更新日期：2020-09-01 00:00:00

abstract：:Lymphocyte enhancer factor 1 (LEF1), a member of the LEF/T-cell-specific factor (TCF) family of the high mobility group domain transcription factors, acts downstream in canonical Wnt signaling. Aberrant transactivation of LEF1 contributes to the tumorigenesis of colonic neoplasms, sebaceous skin tumors, and lymphoblas...

journal_title：Medical molecular morphology

authors： Shimomura A,Takasaki A,Nomura R,Hayashi N,Senda T

更新日期：2013-03-01 00:00:00

abstract：:Dusp22 (dual-specificity phosphatase 22) is considered to regulate various cellular processes through the regulation of protein dephosphorylation. In this study, we prepared a specific antibody against Dusp22, anti-Dusp22, and carried out expression analyses with mouse tissues and cultured cell lines. Western blotting...

journal_title：Medical molecular morphology

authors： Hamada N,Mizuno M,Tomita H,Iwamoto I,Hara A,Nagata KI

更新日期：2018-06-01 00:00:00

abstract：:Generating mesenchymal stem-like cells (MSLCs) from induced pluripotent stem cells (iPSCs) can be a practical method for obtaining the sufficient cells for autologous tissue engineering. Single-cell culturing in specific medium and non-feeder cells is an alternative and promising strategy to overcome problems of embry...

journal_title：Medical molecular morphology

authors： Ueda M,Hashimoto Y,Honda Y,Baba S,Morita S

更新日期：2019-09-01 00:00:00

abstract：:Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied...

journal_title：Medical molecular morphology

authors： Kanomata N,Yamaguchi R,Kurebayashi J,Moriya T

更新日期：2020-03-01 00:00:00

abstract：:Aquaporins (AQPs) are key regulators of water channels across the cell cytoplasm. Little is known about AQP localization and changes in the hepatic microvascular system. This study aimed to clarify the localization of AQP-1 in the microvessels in normal and cirrhotic rat liver. To establish a rat cirrhosis model, thio...

journal_title：Medical molecular morphology

authors： Yokomori H,Oda M,Yoshimura K,Watanabe S,Hibi T

更新日期：2010-03-01 00:00:00

abstract：:Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysin (SYP), and neural cell adhesion molecule (NCAM) were also considered as potential biomarkers. However, it is...

journal_title：Medical molecular morphology

authors： Tanigawa M,Nakayama M,Taira T,Hattori S,Mihara Y,Kondo R,Kusano H,Nakamura K,Abe Y,Ishida Y,Okabe Y,Hisaka T,Okuda K,Fujino K,Ito T,Kawahara A,Naito Y,Yamaguchi R,Akiba J,Akagi Y,Yano H

更新日期：2018-03-01 00:00:00

abstract：:Hirschsprung's disease is a congenital aganglionic neural disorder of the segmental distal intestine characterized by unsettled pathogenesis. The relationship between Hirschsprung's disease and pacemaker cells (PMC), which almost corresponds to that of the interstitial cells of Cajal (ICC), was morphologically observe...

journal_title：Medical molecular morphology

authors： Taniguchi K,Matsuura K,Matsuoka T,Nakatani H,Nakano T,Furuya Y,Sugimoto T,Kobayashi M,Araki K

更新日期：2005-06-01 00:00:00

abstract：:Malignant müllerian mixed tumors (MMMTs) of the fallopian tube are very rare neoplasms, and we present such a case with unusual findings here. A 57-year-old Japanese woman, after she received a medical checkup, underwent salpingo-oophorectomy on the suspicion of ovarian cancer. At the time of operation, the main tumor...

journal_title：Medical molecular morphology

authors： Kuroda N,Inui Y,Ohara M,Hirouchi T,Mizuno K,Kubo A,Hayashi Y,Enzan H,Lee GH

更新日期：2007-03-01 00:00:00

abstract：:Vibrio cholerae colonizes the lumen of the proximal small intestine, which has an alkaline environment, and secretes cholera toxin (CT) through a type II secretion machinery. V. cholerae possesses the intrabacterial nanotransportation system (ibNoTS) for transporting CT from the inner portion toward the peripheral por...

journal_title：Medical molecular morphology

authors： Matsuzaki Y,Wu H,Nakano T,Nakahari T,Sano K

更新日期：2015-12-01 00:00:00

abstract：:E-cadherin expression patterns in acinar cell carcinomas (ACCs) of the pancreas have not been well documented. Herein, we present a hitherto undescribed case of E-cadherin-negative ACC with a solid pseudopapillary growth pattern in a 65-year-old man. We used an antibody against the extracellular domain of E-cadherin. ...

journal_title：Medical molecular morphology

authors： Tajima S,Waki M,Azuma M,Koda K,Ohata A

更新日期：2016-09-01 00:00:00