Case report: extreme CgA elevation under PPI confounding assessment of adrenal mass.

Abstract:

:Measurement of chromogranin A (CgA) level in blood can be used to monitor neuroendocrine tumours. However CgA level may also be elevated in several other endocrine and non-endocrine diseases. Here, we report on a patient with an incidental left-sided adrenal tumour and elevated CgA level. Adrenalectomy did not confirm clinically suspected diagnosis of pheochromocytoma. Postoperative follow-up was remarkable for a persistently elevated CgA level suspecting another neuroendocrine tumour which could not be detected despite extensive investigations. Finally, it was discovered that continuous proton-pump inhibitor administration for gastro-oesophageal reflux disease had caused a falsely elevated CgA level.

journal_name

Z Gastroenterol

authors

Wiedmann MW,Mössner J,Stumvoll M,Führer D

doi

10.1055/s-0028-1109174

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

671-3

issue

7

eissn

0044-2771

issn

1439-7803

journal_volume

47

pub_type

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