Validation of the "German Inflammatory Bowel Disease Activity Index (GIBDI)": An Instrument for Patient-Based Disease Activity Assessment in Crohn's Disease and Ulcerative Colitis.

Abstract:

INTRODUCTION: Assessment of disease activity in Crohn's disease (CD) and ulcerative colitis (UC) is usually based on the physician's evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDICD) and UC (GIBDIUC) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians' documented activity indices. METHODS: Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements. RESULTS: Rank correlations were 0.56 (pMS, GIBDIUC) and 0.57 (HBI, GIBDICD), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories). DISCUSSION: There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information. EINLEITUNG: Die Bestimmung der Krankheitsaktivität bei Morbus Crohn (MC) und Colitis ulcerosa (CU) stützt sich meist auf Arzturteile, endoskopische Befunde oder Biomarker-Analysen. Der German Inflammatory Bowel Disease Activity Index für MC (GIBDIMC) und CU (GIBDICU) nutzt patientenberichtete Fragebogendaten. Unklar ist, inwieweit der GIBDI mit ärztlicherseits dokumentierten Aktivitätsindizes übereinstimmt. METHODIK: Daten aus 2 Studien wurden reanalysiert. In beiden dokumentierten Gastroenterologen die Krankheitsaktivität bei CU mit dem partial Mayo Score (pMS), bei MC mit dem Harvey Bradshaw Index (HBI). Patienten bearbeiteten den GIBDI. Die Analysestichprobe bildeten 151 CU- und 150 MC-Patienten. Als Übereinstimmungsmaße wurden Kappa-Koeffizienten bestimmt. ERGEBNISSE: Es zeigen sich Rangkorrelationen von 0.56 (pMS, GIBDICU) und 0.57 (HBI, GIBDIMC), jeweils p < 0.001. Die absolute Übereinstimmung bei zwei Kategorien der Krankheitsaktivität (Remission ja/nein) ist 74,2 % (CU) bzw. 76,6 % (MC), bei vier Kategorien (keine/leichte/mittlere/schwere) 60,3 % (CU) bzw. 61,9 % (MC). Die Kappa-Werte liegen zwischen 0,47 bei CU (zwei Kategorien) und 0,58 bei MC (vier Kategorien). DISKUSSION: Der GIBDI zeigt eine zufriedenstellende Übereinstimmung mit den ärztlich dokumentierten Aktivitätsindizes. Sein Einsatz bietet sich in Versorgungsforschungsstudien ohne Zugang zu Urteilen ärztlicher Behandler an. In der klinischen Praxis lässt sich der Index als ergänzende Informationsquelle nutzen.

journal_name

Z Gastroenterol

authors

Hüppe A,Langbrandtner J,Häuser W,Raspe H,Bokemeyer B

doi

10.1055/a-0605-4080

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1267-1275

issue

10

eissn

0044-2771

issn

1439-7803

journal_volume

56

pub_type

杂志文章
  • [Diagnosis of oesophageal reflux by PH, impedance, and bilirubin measurement: recommendations of the German Society of Neurogastroenterology and of the working group for neurogastroenterology of the German Society for Digestive and Metabolic Diseases].

    abstract::The current recommendations on indications, technical performance, and interpretation of diagnostic techniques for oesophageal reflux update the German recommandations about 24 hour pH measurement of 2003. The recommendations encompass conventional pH measurement, wireless pH measurement, pH and impedance measurements...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0032-1325483

    authors: Pehl C,Keller J,Allescher HD,Feussner H,Frieling T,Goebel-Stengel M,Gschossmann J,Kuhlbusch-Zicklam R,Mönnikes H,Nguyen HN,Müller M,Schirra J,Storr M,van der Voort I,Yüce B

    更新日期:2012-12-01 00:00:00

  • [Gastroenterology in Germany--determination of current status and perspectives. Results of a survey among members of the German Society of Digestive and Metabolic Diseases].

    abstract:UNLABELLED:The present survey carried out among the members of the German Society of Gastroenterology and Metabolism (GSGM) was intended 1. to provide information on a) age, professional experience and nature of present activities, b) the service spectrum, c) career prospects, and 2 to reflect the views of those questi...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Lux G,Stabenow-Lohbauer U,Langer M,Bozkurt T

    更新日期:1996-09-01 00:00:00

  • Transpapillary retrieval of a proximally migrated stent using a three-prong polyp retrieval device in a 2-years-old girl.

    abstract::Endoscopic retrieval of proximally migrated biliary stents is sometimes challenging. We report on the successful use of a three-prong colon polyp retrieval device in a two year old child. ...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1366050

    authors: Goetz M,Walther U,Malek N,Fuchs J,Königsrainer A,Kratt T

    更新日期:2014-04-01 00:00:00

  • Non-operative management in a case of spontaneous splenic rupture in infectious mononucleosis.

    abstract::Spontaneous splenic rupture as a complication of infectious mononucleosis was diagnosed in a 19-year-old woman. Sonographic and MRI investigations revealed subcapsular hematoma of the spleen without overt rupture. The patient was managed conservatively. Somatostatin treatment was initiated in order to reduce splanchni...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Paar WD,Look MP,Robertz Vaupel GM,Kreft B,Hirner A,Sauerbruch T

    更新日期:1995-01-01 00:00:00

  • [Budesonide foam as a new therapeutic principle in distal ulcerative colitis in comparison with mesalazine enema. An open, controlled, randomized and prospective multicenter pilot study].

    abstract::Budesonide is a locally acting steroid with a high first-pass metabolism in the liver and low systemic effects. We performed the first pilot study comparing budesonide foam (1 mg/50 ml b.i.d.) with mesalazine enemas (4 g/60 ml o.d.). 33 patients from 3 centres were enrolled in this open randomized clinical trial. 16 p...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1055/s-2000-14869

    authors: Rufle W,Frühmorgen P,Huber W,Kimmig JM

    更新日期:2000-04-01 00:00:00

  • [Rational laboratory diagnosis of cholestasis syndrome].

    abstract::Laboratory diagnostics efficiently applied is of decisive importance for a great deal of questions in spite of the technical and endoscopic methods which are available today in the field of examinations. By means of a screening programme consisting of ALAT, gamma-GT, ChE at a sensitivity of > 90% alterations in both t...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Nilius R,Jonczyk M

    更新日期:1993-02-01 00:00:00

  • [Gastrin in the pathogenesis of ulcer disease].

    abstract::The role of endogenous gastrin in the pathogenesis of "idiopathic" ulcer disease is difficult to determine; however, gastrin is probably only of limited importance besides various probable more important factors. In conditions associated with uncontrolled gastrin production by a gastrin secreting tumor or in cases in ...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Koop H

    更新日期:1987-08-01 00:00:00

  • [Long-term HR-Manometry of the Esophagus: first findings in clinical use].

    abstract::Diagnosis of oesophageal motility disorders has been well established for many years now, although circadian gastrointestinal motility is still purely understood. So far, high-resolution manometry (HRM) is only available for short-term measurement in clinical practice to evaluate simultaneous pressure conditions throu...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0042-105653

    authors: Jell A,Wilhelm D,Ostler D,Feußner H,Hüser N

    更新日期:2016-09-01 00:00:00

  • Conservative management of foreign bodies in the gastrointestinal tract.

    abstract::There are at present no clear guidelines whether foreign body ingestion in the gastrointestinal tract should be managed conservatively, endoscopically or surgically. Retrospectively we have, therefore, analyzed 78 foreign body ingestion's in 42 patients (age 15-72 years) admitted to the Emergency Department of the Uni...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Kürkciyan I,Frossard M,Kettenbach J,Meron G,Sterz F,Röggla M,Laggner AN

    更新日期:1996-03-01 00:00:00

  • [Retroperitoneal lymphangiodysplasia with exudative enteropathy. A case of cystic dilated cisterna chyli and splenic cysts].

    abstract::In a 16 years old girl we found the syndrome of exsudative enteropathy with intestinal lymphangiectasy which differs from previous reported cases by several malformations of the lymphatic system. Besides changes in the intestinal lymphatics there was a retroperitoneal lymphangiodysplasia, a reduction and hypoplasia of...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Ferenci P,Wolf G,Feigl W,Tuchmann B,Imhof H,Leypold F,Pesendorfer F

    更新日期:1976-12-01 00:00:00

  • [Frequency and pathogenesis of epitheloid cell granuloma in Crohn's disease (author's transl)].

    abstract::12% of the rectal biopsies (19% of the patients) showed epitheloid cell granulomas in clinically definite Crohn's disease. In colonic biopsies such granulomata were visible in 14% (22% of the patients). Granulomata were scarcely seen in normal or slightly inflamed mucosa. They were mostly found together with crypt abs...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Schmitz-Moormann P,Malchow H,Miller B,Brandes JW

    更新日期:1979-05-01 00:00:00

  • Use of isolated liver perfusion in metabolic studies: ground-laying work in experimental hepatology.

    abstract::Modern metabolic research in hepatology employs non-invasive techniques of the whole organism, and it includes studying the intact organ. Following recent decades of efforts in culturing isolated cells and studying their properties separately, it has become clear that the spatiotemporal organisation of different cell ...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1273392

    authors: Sies H

    更新日期:2011-06-01 00:00:00

  • [Fibrolamellar liver cell cancer. A case report].

    abstract::Fibrolamellar hepatocellular carcinoma of the liver is a rare variant of hepatocellular carcinoma with characteristic morphological patterns and a good prognosis. Preoperatively the tumor is rarely diagnosed. Surgical treatment is resection, hemihepatectomy or transplantation of the liver. We report a case of a 51 yea...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Kahle M,Heilmann KL,Filler RD

    更新日期:1989-06-01 00:00:00

  • [The fluorescein dilaurate serum test following metoclopramide and secretin stimulation for evaluating pancreatic function. Contribution to the diagnosis of chronic pancreatitis].

    abstract::A new method of exocrine pancreatic function testing is described. After oral administration of a standard meal containing fluorescein dilaurate (FDL) metoclopramide (10 mg) and secretin (1 U/kg) are given as intravenous bolus injection. The best discrimination between normal and abnormal pancreatic function was found...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Malfertheiner P,Büchler M,Müller A,Ditschuneit H

    更新日期:1987-04-01 00:00:00

  • [Long-term collagenous sprue--remission with a gluten-free diet].

    abstract::We report on a 56-year-old caucasian female, 154 cm, 38 kg, who was admitted to the hospital in extremely poor, cachectic condition with pretibial edemas, ascites and pleural effusion with a history of severe watery diarrhea up to 15 times daily. The patient's history with permanent meteorism, recurrent episodes of wa...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Holtmann M,von Herbay A,Galle PR,Stremmel W

    更新日期:1999-12-01 00:00:00

  • [Updated S2k-Guideline "Complications of liver cirrhosis". German Society of Gastroenterology (DGVS)].

    abstract::This guideline provides evidence-based key recommendations for diagnosis and therapy of complications of liver cirrhosis and upgrades the 2011 version. An interdisciplinary team of medical experts and patient support groups developed the guideline following the AWMF recommendations for evidence based consensus guideli...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/a-0873-4658

    authors: Gerbes AL,Labenz J,Appenrodt B,Dollinger M,Gundling F,Gülberg V,Holstege A,Lynen-Jansen P,Steib CJ,Trebicka J,Wiest R,Zipprich A,Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV).,Deutsche Gesellschaft für Inner

    更新日期:2019-05-01 00:00:00

  • [Two-stage esophageal resection with ischemic preconditioning of the gastric tube in decompensated dolichomegaesophagus and end-stage achalasia].

    abstract::Development of a megaesophagus with a sigmoid-shaped distal part in patients with achalasia--even in the course of successful myotomy with reduction of the resting pressure of the lower esophageal sphincter--is often the expression of an irreversible progression of the disease. Management of patients with end-stage ac...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027374

    authors: Gockel I,Musholt TJ,Eckardt V,Mildenberger P,Müller H,Lang H

    更新日期:2008-11-01 00:00:00

  • [Comparison of quantitative liver function tests to clinical, laboratory chemical and biopsy findings in patients with liver diseases].

    abstract::Quantitative liver function tests (QLFT), e.g. 1) galactose elimination capacity (GEK) and 2) fractional indocyanine-green elimination constant k (ICG) were performed in patients with various liver diseases. Retrospectively the results of QLFT were compared to clinical, histological and laboratory findings which are k...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Albers I,Hartmann H,Creutzfeldt W

    更新日期:1988-02-01 00:00:00

  • [EHEC-associated colon stenosis after ulcerous-chronic haemorrhagic colitis and consecutive resulting ileus].

    abstract::We report on the case of a segmentally emphasised, ulcerous chronic haemorrhagic colitis with the development of granulation tissue und scarred fibrosis with consecutive resulting stenosis of the colon. A 49-year-old male patient was infected with enterohaemorrhagic Escherichia coli bacteria during the EHEC-epidemic i...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0031-1299059

    authors: Lipp MJ,Schirmer J,Feyerabend B,Stavrou GA,Cordruwisch W,Faiss S,Oldhafer KJ

    更新日期:2012-05-01 00:00:00

  • Gastrointestinal stromal tumours in patients with other-type cancer: a mere coincidence or an etiological association? A study of 97 GIST cases.

    abstract::Gastrointestinal stromal tumours (GIST) occur mostly as sporadic solitary lesions involving the tubular GI tract and are only rarely associated with other benign or malignant neoplasms or occur as part of a multi-neoplastic disease as in the setting of Carney's triad and von Recklinghausen's disease. We analysed a tot...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2005-858378

    authors: Agaimy A,Wuensch PH

    更新日期:2005-09-01 00:00:00

  • [Mirizzi syndrome and its variants].

    abstract::Between 1981 and 1987 5434 patients were studied by ERCP in Allgemeines Krankenhaus Hamburg-Barmbeck. 26 (i.e. 0.43%) suffered from Mirizze syndrome with the triad of cholelithiasis, cholecystitis and obstructive biliary disease. They were classified in four different types according to the variable localisation and o...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Meyer GJ,Runge D,Gebhardt J

    更新日期:1990-04-01 00:00:00

  • [Invasive amebiasis with detection of Entamoeba histolytica in rectal biopsies and liver abscesses].

    abstract::A 45-years old man after having returned from Thailand was admitted to the hospital with a severe ulcerative, pyogenic colitis and multiple liver abscesses. In the endoscopically taken rectal biopsies as well as in the liver abscess aspirate gained by fine needle puncture Throphozoites of E. histolytica could be demon...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Bihl P,Hobik HP,Schmidt-Wilcke HA

    更新日期:1989-02-01 00:00:00

  • [Endoscopy in the intensive care unit].

    abstract::The present study retrospectively evaluates all endoscopies performed on a medical intensive care unit during the period from 1986 to 1992. During these seven years, 415 endoscopies were performed of which 77.8% were done as an upper gastrointestinal endoscopy. The most frequent findings consisted in esophagitis (23.6...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Niederau C,Lübke H,Schumacher B,Strohmeyer G

    更新日期:1994-08-01 00:00:00

  • Tuberculous perihepatic abscess and neurosarcoidosis: report of 2 uncommon manifestations of 2 common granulomatous diseases in 1 patient.

    abstract::Infections caused by pathogens of the Mycobacterium tuberculosis complex, i. e., tuberculosis (TB), and the non-infectious, autoimmune disease sarcoidosis are among the most common granulomatous diseases worldwide. Typically, the lung is the primary site of infection and manifestation, respectively which makes the two...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/a-1330-9046

    authors: Gernert JA,Sirtl S,Macke L,Wittmann E,Strueven AK,Schwarze V,Dichtl K,Neumann J,Mayerle J,Schulz C

    更新日期:2021-01-01 00:00:00

  • [Actors in liver transplantation advocate greater transparency and systematic evaluations of transplant centres].

    abstract:BACKGROUND:Following the introduction of the MELD score, the survival rates have worsened after liver transplantation (LTX) in Germany. Existing organ shortages, shorter survival rates after LTX, and failures in the liver allocation process provide true challenges. Facilitated by a structured questionnaire, the appropr...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0034-1366290

    authors: Roeb E,Graf J,Meyer HJ

    更新日期:2014-08-01 00:00:00

  • [Severe protracted cholestasis after general anesthesia in a patient with Alagille syndrome].

    abstract::A 27-year-old female patient with partial Alagille's syndrome (hypoplasia of the intrahepatic bile ducts, typical facial dysmorphism and skeletal anomalies) developed a marked cholestasis (total bilirubin 59 mg/dl), decrease of liver synthesis tests and ascites four weeks after gynecological surgery with general anest...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Müller C,Jelinek T,Endres S,Loeschke K

    更新日期:1996-12-01 00:00:00

  • [Diagnosis and therapy of chronic viral hepatitis].

    abstract::Recent advances in our understanding of viral hepatitis involve the discovery and further characterization of the hepatitis C virus and the interferon treatment of patients with chronic viral hepatitis. Liver cirrhosis and primary hepatocellular carcinoma can develop after some years of disease. Interferon is the only...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Heintges T,Niederau C,Mohr L,Hensel F,Häussinger D

    更新日期:1996-07-01 00:00:00

  • Celiac disease screening among healthy blood donors in Hungary.

    abstract:BACKGROUND:Celiac disease (CD) is a common chronic systemic autoimmune disease in Europe. The prevalence of CD in Hungarian children is estimated at 1.2 - 1.4 %. To date, however, no data on adult CD prevalence has been published. AIMS:Analysis of the serological evidence for CD among Hungarian adults in order to esti...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-0033-1335450

    authors: Sárdy M,Kornseé Z,Kelemen D,Papp S,Medvecz M,Kárpáti S

    更新日期:2013-11-01 00:00:00

  • [Lipid island (xanthelasma) of the duodenal mucosa--a rarely found diagnosis and differential diagnosis].

    abstract::A case report ist given on a 54-year-old patient with the so called lipid island (xanthelasma) in the duodenal mucosa. Xanthelasmas are very rarely located in the duodenal mucosa. The diagnosis and differential diagnosis of this entity are reported. The relevance of histochemistry and immunohistochemistry for differen...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Knolle J,Wessel H,Hildebrandt E

    更新日期:1995-08-01 00:00:00

  • [Gastrointestinal complications of adult patients with cystic fibrosis].

    abstract::Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. The primary cellular defect, the reduced expression of the cystic fibrosis transmembrane conductance regulator (CFTR), leading to a chloride secretory defect, is present in all epithelial cells of endodermal and mesodermal...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Bargon J,Stein J,Dietrich CF,Müller U,Caspary WF,Wagner TO

    更新日期:1999-08-01 00:00:00