Abstract:
INTRODUCTION: Assessment of disease activity in Crohn's disease (CD) and ulcerative colitis (UC) is usually based on the physician's evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDICD) and UC (GIBDIUC) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians' documented activity indices. METHODS: Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements. RESULTS: Rank correlations were 0.56 (pMS, GIBDIUC) and 0.57 (HBI, GIBDICD), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories). DISCUSSION: There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information. EINLEITUNG: Die Bestimmung der Krankheitsaktivität bei Morbus Crohn (MC) und Colitis ulcerosa (CU) stützt sich meist auf Arzturteile, endoskopische Befunde oder Biomarker-Analysen. Der German Inflammatory Bowel Disease Activity Index für MC (GIBDIMC) und CU (GIBDICU) nutzt patientenberichtete Fragebogendaten. Unklar ist, inwieweit der GIBDI mit ärztlicherseits dokumentierten Aktivitätsindizes übereinstimmt. METHODIK: Daten aus 2 Studien wurden reanalysiert. In beiden dokumentierten Gastroenterologen die Krankheitsaktivität bei CU mit dem partial Mayo Score (pMS), bei MC mit dem Harvey Bradshaw Index (HBI). Patienten bearbeiteten den GIBDI. Die Analysestichprobe bildeten 151 CU- und 150 MC-Patienten. Als Übereinstimmungsmaße wurden Kappa-Koeffizienten bestimmt. ERGEBNISSE: Es zeigen sich Rangkorrelationen von 0.56 (pMS, GIBDICU) und 0.57 (HBI, GIBDIMC), jeweils p < 0.001. Die absolute Übereinstimmung bei zwei Kategorien der Krankheitsaktivität (Remission ja/nein) ist 74,2 % (CU) bzw. 76,6 % (MC), bei vier Kategorien (keine/leichte/mittlere/schwere) 60,3 % (CU) bzw. 61,9 % (MC). Die Kappa-Werte liegen zwischen 0,47 bei CU (zwei Kategorien) und 0,58 bei MC (vier Kategorien). DISKUSSION: Der GIBDI zeigt eine zufriedenstellende Übereinstimmung mit den ärztlich dokumentierten Aktivitätsindizes. Sein Einsatz bietet sich in Versorgungsforschungsstudien ohne Zugang zu Urteilen ärztlicher Behandler an. In der klinischen Praxis lässt sich der Index als ergänzende Informationsquelle nutzen.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Hüppe A,Langbrandtner J,Häuser W,Raspe H,Bokemeyer Bdoi
10.1055/a-0605-4080subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1267-1275issue
10eissn
0044-2771issn
1439-7803journal_volume
56pub_type
杂志文章abstract:BACKGROUND:Radiation enteritis is a severe problem in patients receiving irradiation of the abdomen or pelvis in the course of cancer treatment. Nevertheless, there is a lack of standardised strategies for medical prevention and therapy. MATERIALS AND METHODS:A PubMed based literature search was performed to address t...
journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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更新日期:1994-02-01 00:00:00
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更新日期:1988-11-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
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doi:
更新日期:1985-05-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-02-01 00:00:00
abstract::Background and aims Therapy of hepatocellular carcinoma (HCC) mainly depends on tumor stage and liver function. The aim of this study was to identify additional predictors of overall survival in HCC patients with a particular attention to multimodal therapies. Methods Six hundred and seven consecutive HCC-patients tre...
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pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,评审
doi:
更新日期:1982-07-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,评审
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,meta分析
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更新日期:2005-05-01 00:00:00