Pathophysiologic mechanisms of anemia of chronic disease.

Abstract:

:Anemia of chronic disease (ACD) is a prevalent condition commonly observed in patients with chronic infections, cancer, trauma, and inflammatory disorders. In this article, Dr Andrews examines new research findings that enhance the understanding of the pathophysiologic mechanisms of ACD. After a brief review of iron homeostasis and a look at ACD in a historical context, she explores the significance of hepcidin, a recently discovered hormone involved in iron metabolism, and discusses a new hypothesis that connects hepcidin to the pathogenesis of ACD. Dr Andrews also examines the link between ACD and hereditary hemochromatosis, 2 disorders that on the surface may seem quite different but have in common the involvement of hepcidin in their pathogenesis.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Andrews NC

doi

10.3810/pgm.11.2004.suppl36.250

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

17-22

issue

5 Suppl Anemia

eissn

0032-5481

issn

1941-9260

journal_volume

116

pub_type

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