Update on pulmonary arterial hypertension pharmacotherapy.

Abstract:

:Pulmonary artery hypertension (PAH) refers to several subgroups of disease in which the mean pulmonary artery pressure (mPAP) is elevated to more than 25 mm Hg, pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg, and an elevated pulmonary vascular resistance (PVR) > 3 Wood units as confirmed by right heart catheterization. The prevalence and geographic distribution of PAH vary depending on the type and etiology of the disease. Despite enormous efforts in the research and development of therapeutic agents in the last twenty years, the disease remains relatively incurable and the overall prognosis remains guarded. Median survival for an untreated patient is 2.8 years. In the last three decades, there have been dramatic advances in understanding the molecular mechanisms and signaling pathways involved in the disease, resulting in emerging new treatment strategies. In the following pages, we will review currently approved treatments for PAH, as well as a new generation of investigational drugs.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Velayati A,Valerio MG,Shen M,Tariq S,Lanier GM,Aronow WS

doi

10.1080/00325481.2016.1188664

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

460-73

issue

5

eissn

0032-5481

issn

1941-9260

journal_volume

128

pub_type

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