Endotoxin testing.

abstract：OBJECTIVES:The use of psychotropic drugs has increased continuously over recent years in industrialized countries. In Europe, France has the highest consumption of such drugs. The aim of this study was to identify the sociodemographic and medical factors associated with the use of psychotropic agents. METHODS:Data, co...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Empereur F,Baumann M,Alla F,Briançon S

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL). METHODS:A total of 770 steady-state serum concentration samples was analysed. These were collected during VPA therapy from 255 child...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Serrano BB,García Sánchez MJ,Otero MJ,Buelga DS,Serrano J,Domínguez-Gil A

更新日期：1999-02-01 00:00:00

abstract：:The shelf-life of vancomycin in infusion fluids was studied using high-performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in water-for-injections BP at 25 degrees C and stored in plastic syringes (Becton Dickins...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wood MJ,Lund R,Beavan M

更新日期：1995-12-01 00:00:00

abstract：:The subject of 'drug addiction' is multifaceted and many aspects of it (even some of the definitions) are controversial. Collateral medical problems include the spread of HIV and hepatitis C virus secondary to i.v. drug abuse and effects on prenatal brain development (1). Progress in the understanding of the causes of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Betz C,Mihalic D,Pinto ME,Raffa RB

更新日期：2000-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Polypharmacy has a significant impact on patients' health with overall expenditure on over-the-counter (OTC) medicines representing a substantial burden in terms of cost of treatment. The aim of this study, which was conducted within the framework of a European Project funded by the European...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kamekis A,Bertsias A,Moschandreas J,Petelos E,Papadakaki M,Tsiantou V,Saridaki A,Symvoulakis EK,Souliotis K,Papadakis N,Faresjö T,Faresjö A,Martinez L,Agius D,Uncu Y,Sengezer T,Samoutis G,Vlcek J,Abasaeed A,Merkouri

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acute coronary syndrome (ACS) is a leading cause of death. Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines. STUDY METHOD...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rajapakse S,Rodrigo PC,Selvachandran J

更新日期：2010-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT:There are two classes of epi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Peedicayil J

更新日期：2012-10-01 00:00:00

abstract：:In this study, the serum vitamin E (total tocopherol) levels in patients with breast cancer (n = 100) and healthy controls (n = 70) were measured. The mean values for vitamin E were found to be 0.44 mg/100 ml in breast cancer patients and 1.108 mg/100 ml in controls. In the statistical evaluation, the vitamin E levels...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Torun M,Akgül S,Sargin H

更新日期：1995-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang D,Hao J,Hou R,Yu Y,Hu B,Wei L

更新日期：2020-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:It is well known that medication reconciliation at discharge is a key strategy to ensure proper drug prescription and the effectiveness and safety of any treatment. Different types of interventions to reduce reconciliation errors at discharge have been tested, many of which are based on the ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： García-Molina Sáez C,Urbieta Sanz E,Madrigal de Torres M,Vicente Vera T,Pérez Cárceles MD

更新日期：2016-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hu Y,Li Z,Mi DH,Cao N,Zu SW,Wen ZZ,Yu XL,Qu Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Reed RC,Meinhold J,Dutta S,Liu W,Qiu Y

更新日期：2010-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Lee SH,Kim JH

更新日期：2020-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:An imbalance in the genetically controlled pro- and anti-inflammatory cytokine production could potentially promote ongoing low-grade inflammation following an episode of acute gastroenteritis and, subsequently, could result in irritable bowel syndrome (IBS; post-infectious IBS, PI-IBS). Sin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sun MH,Sun LQ,Guo GL,Zhang S

更新日期：2019-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adherence to evidence-based drug therapy after acute myocardial infarction has increased over the last decades, but is still unsatisfactory. Our objectives are to set out to analyse patterns of evidence-based drug therapy after acute myocardial infarction (AMI), and evaluating socio-demograp...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kirchmayer U,Agabiti N,Belleudi V,Davoli M,Fusco D,Stafoggia M,Arcà M,Barone AP,Perucci CA

更新日期：2012-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. CASE SUMMARY DESCRIPTION:The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglycerid...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Ma S,Liu S,Wang Q,Chen L,Yang P,Sun H

更新日期：2020-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type. Although MBZ has been reported to cause hepatic injury, case reports of severe hepatic injury are very rare. We report a case of severe hepatitis after administration of MBZ in a patient with Gilbert's synd...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tolomeo M,Colomba C,Meli M,Cascio A

更新日期：2019-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin has been used for the management of post-herpetic neuralgia (PHN). However, inconsistent results have been reported. This meta-analysis was performed to assess the efficacy and safety of gabapentin 1800 mg/day in PHN patients by conducting a meta-analysis. METHODS:Electronic data...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fan H,Yu W,Zhang Q,Cao H,Li J,Wang J,Shao Y,Hu X

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To report a case of a patient with psoriatic arthritis (PsA) receiving adalimumab, who developed an exacerbation of palmoplantaris pustulosa psoriasis. CASE SUMMARY:A 38-year-old woman diagnosed with PsA had received treatment with non-steroidal antiinflammatory drugs. Two months prior to admission, the pati...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Borrás-Blasco J,Gracia-Perez A,Nuñez-Cornejo C,Rosique-Robles JD,Mateu-Puchades A,Casterá MD,Rubio-Fabra M

更新日期：2008-06-01 00:00:00

abstract：:A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis. We report on two patients, treated with felodipine and nifedipine for arterial hypertension, who presented with an exacerbation of their myasthenia gravis and a myasthenic syndrome or exacerbation of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Pina Latorre MA,Cobeta JC,Rodilla F,Navarro N,Zabala S

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:There is currently a lot of concern about the quality and therapeutic effectiveness of Mexican pharmaceutical products, and considerable price differences between alternative products containing the same active principle. OBJECTIVE:To establish whether four Mexican drug products, a high price and three lowe...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hernández-Abad VJ,Castañeda-Hernández G,García-Jiménez S,Marroquín-Segura R,Sánchez-González E

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Moxifloxacin is a new fluorquinolone with broad-spectrum activity. It is suitable for treating peritonitis in peritoneal dialysis (PD) patients. The objective of this study was to test stability of moxifloxacin in PD solutions stored at different temperatures. METHODS:Dialysis solution bags we...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fernández-Varón E,Marín P,Espuny A,Villamayor L,Escudero E,Cárceles C

更新日期：2006-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:SB5 is a biosimilar to the reference adalimumab (ADL) currently in development. The primary study objective was to demonstrate pharmacokinetic (PK) equivalence of SB5 to European Union-sourced adalimumab (EU-ADL), and United States-sourced adalimumab (US-ADL) in healthy subjects. Safety, tol...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shin D,Lee Y,Kim H,Körnicke T,Fuhr R

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The use of prophylactic antibiotics in clean operations was routine in China before 2011. Along with the appeal for using antibiotics rationally by WHO in 2011, China launched a national special rectification scheme on clinical use of antibiotics from April that year. The scheme, aimed at ac...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhou Y,Ma LY,Zhao X,Tian SH,Sun LY,Cui YM

更新日期：2015-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Since the beginning of the COVID-19 outbreak in China in December 2019, the epidemic has continued to spread globally. Despite continuous reports of clinical trials being launched, no studies have yet systematically summarized and analysed their characteristics. Our objective is to do this b...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang Y,Zhou Q,Xu M,Kang J,Chen Y

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lee DG,Chae H,Yim DS,Park SH,Choi SM,Kim S,Choi JH,Yoo JH,Shin WS

更新日期：2009-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Despite recommendations to avoid fluoroquinolones (FQs) as a first-line treatment for uncomplicated cystitis, recent data suggest that FQs remain widely prescribed. Therefore, the objectives of this study were to evaluate the appropriateness of empiric FQ use compared to nitrofurantoin for u...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Robinson TF,Barsoumian AE,Aden JK,Giancola SE

更新日期：2020-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Many refractory/relapsed haematological malignancies, in non-remission state, still have poor prognosis even after allogeneic haematopoietic stem cell transplantation. Recently, decitabine or umbilical cord blood transplantation (UCBT) seemed to be effective in these patients. However, few s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Yao W,Chu X,Fang X,Zhu X,Tang B,Wan X,Geng L,Tong J,Song K,Zhang X,Qiang P,Sun G,Liu H,Sun Z

更新日期：2020-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Acquired long QT syndrome secondary to drug-induced QT prolongation and torsades de pointes has been reported for antiviral drugs. However, no studies have reported an association between corrected QT (QTc) prolongation and antiviral therapy in patients with novel coronavirus disease (COVID-...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhu S,Wang J,Wang Y,Chu J,Liu Y,Chen X,Chen X

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To probe the pharmacokinetic basis for the use of levofloxacin for complicated skin and skin-structure infections (SSSIs) at a once-daily dosage of 750 mg by investigating its penetration into skin tissue. METHOD:Ten healthy volunteers were administered three oral, once-daily 750 mg doses of levofloxacin, an...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chow AT,Chen A,Lattime H,Morgan N,Wong F,Fowler C,Williams RR

更新日期：2002-04-01 00:00:00