Conceptualizing child health disparities: a role for developmental neurogenomics.

Abstract:

:Biological, psychological, and social processes interact over a lifetime to influence health and vulnerability to disease. Those interested in studying and understanding how and why racial/ethnic and social disparities emerge need to focus on the intersection of these processes. Recent work exploring molecular epigenetic mechanisms of gene expression (in humans as well and other mammalian systems) has provided evidence demonstrating that the genome is subject to regulation by surrounding contexts (eg, cytoplasmic, cellular, organismic, social). The developing stress axis is exquisitely sensitive to regulation by social forces represented at the level of the epigenome. Old assumptions about an inert genome are simply incorrect. Epigenetic processes may provide the missing link that will allow us to understand how social and political conditions, along with individual subjective experiences, can directly alter gene expression and thereby contribute to observed social inequalities in health. Developmental neurogenomics may provide the direct link between the biological and social/psychological worlds. These biological mechanisms of plasticity (at the level of gene expression and regulation) may play a profound role in how we conceptualize health inequalities by informing our concepts regarding the somatization or embodiment of social inequalities.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Francis DD

doi

10.1542/peds.2009-1100G

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

S196-202

eissn

0031-4005

issn

1098-4275

pii

124/Supplement_3/S196

journal_volume

124 Suppl 3

pub_type

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