Abstract:
BACKGROUND:Meningococcal conjugate vaccination is recommended in the United States. This study evaluates the safety of quadrivalent meningococcal conjugate vaccine in a cohort aged 11 to 21 years. METHODS:This cohort study with self-controlled case-series analysis was conducted at Kaiser Permanente Southern California. Individuals receiving MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, during September 30, 2011 to June 30, 2013, were included. Twenty-six prespecified events of interest (EOIs), including neurologic, rheumatologic, hematologic, endocrine, renal, pediatric, and pediatric infectious disease EOIs, were identified through electronic health records 1 year after vaccination. Of these, 16 were reviewed by case review committees. Specific risk and comparison windows after vaccination were predefined for each EOI. The relative incidence (RI) and 95% confidence intervals (CIs) were estimated through conditional Poisson regression models, adjusted for seasonality. RESULTS:This study included 48 899 vaccinated individuals. No cases were observed in the risk window for 14 of 26 EOIs. The RI for Bell's palsy, a case review committee-reviewed EOI, was statistically significant (adjusted RI: 2.9, 95% CI: 1.1-7.5). Stratified analyses demonstrated an increased risk for Bell's palsy in subjects receiving concomitant vaccines (RI = 5.0, 95% CI = 1.4-17.8), and no increased risk for those without concomitant vaccine (RI = 1.1, 95% CI = 0.2-5.5). CONCLUSIONS:We observed a temporal association between occurrence of Bell's palsy and receipt of MenACWY-CRM concomitantly with other vaccines. The association needs further investigation as it could be due to chance, concomitant vaccination, or underlying medical history predisposing to Bell's palsy.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Tseng HF,Sy LS,Ackerson BK,Hechter RC,Tartof SY,Haag M,Slezak JM,Luo Y,Fischetti CA,Takhar HS,Miao Y,Cunnington M,Solano Z,Jacobsen SJdoi
10.1542/peds.2016-2084subject
Has Abstractpub_date
2017-01-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2016-2084journal_volume
139pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:This article describes the methods used and the program performance results for the first 5 years of newborn screening for cystic fibrosis (CF) in California. METHODS:From July 16, 2007, to June 30, 2012, a total of 2,573,293 newborns were screened for CF by using a 3-step model: (1) measuring immunoreactiv...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-0811
更新日期:2015-12-01 00:00:00
abstract::A retrospective study of risk factors for traumatic infant deaths in Oregon occurring from 1973 through 1982 was performed using vital records and medical examiner records. A total of 146 such deaths occurred during this period. Relative risks were calculated for various risk factors in the study group compared with a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVES:Adolescents with justice system involvement have high rates of physical and behavioral health disorders and are potentially high users of costly health care services. We examined emergency department (ED) and hospital use among a national sample of adolescents with various levels of justice involvement. MET...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1144
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS:Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of sta...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-3943
更新日期:2017-07-01 00:00:00
abstract::The clinical course, laboratory data, outcome, and autopsy findings in 61 pediatric patients with suspected brain death were reviewed. In 58% of patients, the initial EEG was isoelectric, and cerebral blood flow was absent. In six of nine children, the initial EEG, which showed activity, became isoelectric by 72 hours...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Between June 1979 and June 1989, 54 children with urolithiasis were evaluated and treated at the Johns Hopkins Children's Center. The most common symptoms were flank or abdominal pain (58%) and gross hematuria (28%). In 46 children (86%), stones were secondary to a preexisting condition and in only 8 (14%) no apparent...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::: media-1vid110.1542/5849572227001PEDS-VA_2018-2516Video Abstract OBJECTIVES: For decades, infants with Duarte galactosemia (DG) have been identified by newborn screening (NBS), but whether they should be treated with dietary restrictions of galactose has remained unknown. To clarify, we conducted a study of dietary a...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2018-2516
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Critical congenital heart disease has been proposed as a target of newborn screening. This study aimed to define the incidence and timing of significant physiologic compromise attributable to critical congenital heart disease as well as the distribution of vulnerable lesions. These descriptive parameters must...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0421
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vita...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2012-3986
更新日期:2013-10-01 00:00:00
abstract::Gastrointestinal food allergies are a spectrum of disorders that result from adverse immune responses to dietary antigens. The named disorders include immediate gastrointestinal hypersensitivity (anaphylaxis), oral allergy syndrome, allergic eosinophilic esophagitis, gastritis, and gastroenterocolitis; dietary protein...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract::In 1977, 7% of the 38,855 infants born in Utah were estimated to have required a total of 27,439 special-care hospital days. About half (53%) were mildly ill; their average length of stay was 4.6 days, or 24% of the total hospital-days. Another 20% of the infants had intermediate illness, with a 12-day average stay, o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVE:To determine if serum levels of S100B are higher in children with CHT and ICI as detected by cranial CT and if long bone fractures affect the level of S100B in children with CHT and skeletal injury. METHODS:Children <18 years of age who presented to an urban pediatric emergency department or were transferred...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1493
更新日期:2009-10-01 00:00:00
abstract::It is unclear why children of adolescent mothers experience more developmental problems than children of adult mothers. There has been minimal systematic investigation of whether there is a relationship between the young age of the mother and her mothering behaviors. Our data fail to demonstrate any relationship betwe...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVE:Health-e-Access, a telemedicine service providing care for acute illnesses in children, has delivered >6500 telemedicine visits from 10 primary care practices in Rochester, New York, by using telemedicine access at 22 child care and school sites. The goal was to assess the hypotheses that children served by H...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2698
更新日期:2009-06-01 00:00:00
abstract::Diabetic ketoacidosis (DKA) is a life-threatening condition and a major cause of morbidity and mortality in children with type 1 diabetes mellitus. The deficiency of insulin leads to metabolic decompensation, causing hyperglycemia and ketosis that resolves with the administration of insulin and fluids. However, an ind...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0741
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether the consumption of a nutrient-enriched formula after hospital discharge determines different growth and weight gain composition in preterm infants according to intra- and extrauterine growth pattern. METHODS:Two hundred seven preterm infants were randomized at term-corrected age to rec...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2012-1193
更新日期:2012-11-01 00:00:00
abstract::Initial reports of congenital Zika virus (ZIKV) infection focused on microcephaly at birth with severe brain anomalies; the phenotype has broadened to include microcephaly that develops after birth and neurodevelopmental sequelae. In this narrative review, we summarize medical literature describing motor abnormalities...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2017-2038F
更新日期:2018-02-01 00:00:00
abstract::Data on the levels of high-density lipoprotein-cholesterol (HDL-C) and subfractions in 102 adolescent twin pairs and their parents are presented. Children with a family history of premature cardiovascular death had lower levels of HDL2-C than did those without such a history. White girls reporting a high level of phys...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Use of complementary and alternative medical therapies is common and increasing, particularly for children with chronic disease. OBJECTIVES:The purpose of this work was to describe the use of complementary and alternative medicine by children and to identify factors that may influence the use of complementa...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-3105
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:Using nationally representative data, we examined biological, medical system, and sociodemographic factors that are associated with health-related quality of life as measured by a multidimensional index that accounts for a wide range of child health domains. METHODS:Children aged > or = 6 years (N = 69,031) ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0480
更新日期:2008-01-01 00:00:00
abstract::Localized abscess formation is a rare but previously described manifestation of Haemophilus influenzae infection. A majority of the reported cases were caused by nontypeable strains of H influenzae. We report a case of an extensive subscapular abscess due to beta-lactamase-negative H influenzae type B. This, to our kn...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:To examine factors that predict the initiation of expressed milk feedings and the transition to direct breastfeedings among mothers of very low birth weight (VLBW) infants. METHODS:The sample consists of 361 mother-infant pairs enrolled in a follow-up study of children aged 6 to 8 years who were born weighin...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.6.1337
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Acute sinusitis is frequently diagnosed in young children, yet little is known regarding pediatrician practices surrounding its diagnosis and management. OBJECTIVES:The purpose of this work was to describe how pediatricians diagnose and manage nonsevere acute sinusitis in otherwise healthy children < or =6 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2479
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Because previous studies have found allergic contact sensitization common in children by 5 years of age, our aim was to determine the prevalence of positive epicutaneous test results in children <5 years of age and to determine whether sensitization to contact allergens was as common in infancy. METHODS:We r...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.1.e3
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of pacifier use and whether this habit adversely affects the health of 6-month-old infants. DESIGN:Data collected via self-completion questionnaires from mothers forming part of the prospective, population-based Avon Longitudinal Study of Pregnancy and Childhood. METHODS:The mothers...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.3.e34
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To assess compliance with the Centers for Disease Control and Prevention (CDC) evidence-based guidelines for the judicious use of antimicrobials in children with acute otitis media (AOM). METHODS:Compliance with CDC's recommended diagnostic criteria and antimicrobial treatments for management of AOM was asse...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.1.143
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:Bullying and being bullied have been recognized as health problems for children because of their association with adjustment problems, including poor mental health and more extreme violent behavior. It is therefore important to understand how bullying and being bullied affect the well-being and adaptive func...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.6.1231
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Traffic crashes are the leading health threat to children in the United States, resulting in nearly 1 million injuries annually. The psychological consequences of these injuries are primarily unknown. The aims of this study were to estimate the prevalence of posttraumatic stress disorder (PTSD) in traffic-in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.6.1293
更新日期:1999-12-01 00:00:00
abstract::This article, written by a group of experienced parents of children with medical complexity (CMC), provides an overview of the demands of managing care from their unique perspective. The article articulates why attention to understanding the challenges that families of CMC face with a fragmented health care system, in...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2017-1284D
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Use of specific services may help to optimize health for children with autism spectrum disorder (ASD); however, little is known about their service use patterns. We aimed to (1) define service use groups and (2) determine associations of sociodemographic, developmental, behavioral, and health ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2019-1895Q
更新日期:2020-04-01 00:00:00