Sudden infant death syndrome and small airway occlusion: facts and a hypothesis.

Abstract:

:Respiratory failure is almost certainly the cause of death in the majority of cases of sudden infant death syndrome (SIDS), but the mechanisms leading to it have not been elucidated. SIDS shares many environmental and socioeconomic risk factors with severe forms of bronchiolitis, and the age distribution of incident cases is similar. Present knowledge of lung and airway development during infancy, determinants of peripheral airway patency, changes in lung surface activity in infants with SIDS, and fluid film dynamics in small airways are reviewed. It is hypothesized that many cases of SIDS may be due to a final episode of progressive peripheral bronchial occlusion in infants with preceding critically diminished conductance of the smaller airways.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Martinez FD

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

190-8

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

87

pub_type

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