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GAG-binding variants of tick-borne encephalitis virus.

Abstract：

:Previously different authors described various flavivirus mutants with high affinity to cell glycosaminoglycans and low neuroinvasiveness in mice that were obtained consequently passages in cell cultures or in ticks. In present study the analysis of TBEV isolates has shown existence of GAG-binding variants in natural virus population. Affinity to GAG has been evaluated by sorption on heparin-Sepharose. GAG-binding phenotype corresponds to such virus properties, like small plaque phenotype in PEK cells, absence of hemagglutination at pH 6.4, and low neuroinvasiveness in mice. Mutations increasing charge of E protein were necessary but not sufficient for acquisition of GAG-binding phenotype. Molecular modeling and molecular dynamics simulation have shown that the flexibility of E protein molecule could bear influence on the phenotypic manifestation of substitutions increasing charge of the virions.

journal_name

Virology

journal_title

Virology

authors

Kozlovskaya LI,Osolodkin DI,Shevtsova AS,Romanova LIu,Rogova YV,Dzhivanian TI,Lyapustin VN,Pivanova GP,Gmyl AP,Palyulin VA,Karganova GG

doi

10.1016/j.virol.2009.12.012

subject

Has Abstract

pub_date

2010-03-15 00:00:00

pages

262-72

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(09)00797-1

journal_volume

398

pub_type

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