Abstract：
BACKGROUND:The available evidence regarding the possible effects of resveratrol on liver function is inconsistent. Therefore, the present meta-analysis was performed to investigate the overall effects of resveratrol supplementation on liver enzymes in adults. METHODS:A systematic and comprehensive search of the online medical databases including PubMed, Scupos, Web of Science and Cochran Library was performed up to February 2020. All RCTs using resveratrol supplements in adults were included in this systematic review and meta-analysis. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model. RESULTS:Finally, 15 randomised trials including 714 participants were selected for the present meta-analysis. Pooled analysis did not show any significant changes in alanine aminotransferase (ALT) (WMD: 0 IU/L, 95% CI: -3.17 to 3.17, P = .99; I2 = 74.2%), aspartate aminotransferase (AST) (WMD: -2.40 IU/L, 95% CI: -5.45 to 0.65, P = .11; I2 = 82.9%), gamma-glutamyl transferase (GGT) (WMD: -1.26 IU/L, 95% CI: -4.64 to 2.13, P = .64; I2 = 23.7%), alkaline phosphatase (ALP) (WMD: 3.80 IU/L, 95% CI: -4.65 to 12.25, P = .37; I2 = 29.9%) and bilirubin (WMD: 0.13 IU/L, 95% CI: -0.43 to 0.17, P = .39; I2 = 8.9%) after supplementation with resveratrol. CONCLUSION:Overall, in our study, resveratrol does not affect liver enzyme levels significantly, but subgroup analysis indicates that these results may be influenced by resveratrol dose, duration of the study and population status, so future high-quality studies are necessary to get definitive results.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Darand M,Farrokhzad A,Ghavami A,Hadi A,Karimi E,Fadel A,Askari Gdoi
10.1111/ijcp.13692subject
Has Abstractpub_date
2020-08-31 00:00:00pages
e13692eissn
1368-5031issn
1742-1241pub_type
杂志文章abstract：:Systolic heart failure (SHF) is associated with increased morbidity and mortality. Beta-blockers (BB) were shown to provide mortality benefit in patients with SHF, and currently indicated in all stages of patients with SHF. We evaluated the factors influencing the prescription of BBs at discharge in patients hospitali...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.01157.x
更新日期：2007-02-01 00:00:00
abstract：:Over the past years, there has been an explosive increase in the prevalence of type 2 diabetes (T2DM) and this is expected to continue, entailing associated morbidity and mortality. An increasing number of studies explore the different ways T2DM could be prevented. On-going lifestyle modifications need to be addressed...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2006.00929.x
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of healthcare provider (HCP) type (primary vs. specialist) on glycaemic control and other treatment parameters. RESEARCH DESIGN AND METHODS:Study of Once-Daily Levemir (SOLVE(™) ) is an international, 24-week, observational study of insulin initiation in people with type 2 diabetes....
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/ijcp.12776
更新日期：2016-03-01 00:00:00
abstract：:The Surgical Nutrition Advisory Team (SNAT) of our hospital, formed in October 1992, decided to study the impact of such a team on the six months before and after its formation on catheter care and nutritional support in total parenteral nutrition. Our study showed that with a dedicated nutritional team, catheter seps...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To determine the efficacies of different preparations of glucosamine for the treatment of osteoarthritis (OA). METHODS:Systematic searches of the bibliographic databases Medline, Embase, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews for randomised, double-...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ijcp.12115
更新日期：2013-06-01 00:00:00
abstract：:A high prevalence of newly detected diabetes mellitus (DM) and impaired glucose tolerance (IGT) has been reported in patients with acute myocardial infarction (AMI) and no previous diagnosis of DM. However, the prevalence of newly detected DM is grossly underestimated by using fasting plasma glucose (FPG). We determin...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2007.01301.x
更新日期：2007-04-01 00:00:00
abstract：AIMS:To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia. METHODS:A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treat...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12954
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:There is abundant evidence that patients with rheumatoid arthritis (RA) are at elevated cardiovascular (CV) risk. The contribution of lipids in general is well recognised, but is as yet unclear in inflammatory diseases such as RA in part because inflammation appears inversely associated with lipid levels in ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2009.02220.x
更新日期：2010-09-01 00:00:00
abstract：:The potential effect of orlistat on cardiovascular co-morbidities may have been previously underestimated. This study assesses the efficacy of orlistat therapy for weight loss and cardiovascular risk factor reduction in obese patients with cardiovascular risk. This was a 54-week, double-blind, randomised, placebo-cont...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2002-09-01 00:00:00
abstract：AIMS:The impact of ongoing PCR positivity on COVID-19 patients and the strategy and period of isolation were not fully understood. We aimed to investigate the factors that cause prolonged PCR positivity and its clinical impact on COVID-19 infection. In addition, we searched for an answer on what length of time would be...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.14025
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:Incretin-based therapies offer another treatment option for patients with type 2 diabetes. Agents that provide glycaemic control in addition to attenuating cardiovascular disease (CVD) risk factors are important for diabetes management. This review will focus on the off-target effects of incretin-based thera...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.12572
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:We recently described early rigid retrograde endoscopic realignment of the disrupted urethra under caudal anaesthesia in the outpatient setting. This retrospective study was performed to evaluate our medium-term results. PATIENTS AND METHODS:A retrospective review of patients who had early rigid retrograde e...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2007.01481.x
更新日期：2010-01-01 00:00:00
abstract：:Gas explosion during diathermy gastrotomy is a very rare occurrence. We report on an unusual case of gas explosion during diathermy gastrotomy in a patient with carcinoma of the gastric antrum. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:Spontaneous tumour lysis syndrome (STLS) inducing acute uric acid nephropathy, a rare and neglected disease, presents more insidiously than conventional post-treatment tumour lysis syndrome. Although STLS is a serious and potentially fatal complication in patients with neoplastic disorders, few investigations have add...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To conduct a comparative study of retinal nerve fibre layer (RNFL) thickness and choroidal thickness of psoriasis patients and healthy volunteers. METHODS:This study included 35 severe psoriasis patients, 35 mild psoriasis patients and 35 healthy individuals. RNFL and choroidal thickness analysis...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13904
更新日期：2020-12-08 00:00:00
abstract：BACKGROUND AND AIMS:The use of herbs and dietary supplements (HDS) alone or concomitantly with medications can potentially increase the risk of adverse events experienced by the patients. This review aims to evaluate the documented HDS-drug interactions and contraindications. METHODS:A structured literature review was...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2012.03008.x
更新日期：2012-11-01 00:00:00
abstract：AIMS:The aims of this study were to determine the diagnostic yield of a dedicated heart failure diagnosis clinic and the impact of using different guideline recommended N-terminal pro B-type natriuretic peptide (NT-proBNP) referral thresholds on diagnosis and referral patterns. METHODS AND RESULTS:Patients referred by...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12694
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:The regular use of simple analgesics in addition to opioids such as paracetamol (or acetaminophen) is recommended for persistent pain to enhance analgesia. Few studies have examined the frequency and doses of paracetamol among people with chronic non-cancer pain including use above the recommended maximum da...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12716
更新日期：2015-11-01 00:00:00
abstract：:In this journal, Cummins et al reported an experiment that examined clinicians' predictions of causes of death from subjects' pre-morbid photographs. They found that clinicians performed at chance. The validity of two of their other conclusions are challenged. First, that clinicians routinely form impressions of how a...
journal_title：International journal of clinical practice
pub_type： 评论,杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：AIMS:To analyse the predictive capacity of 15 machine learning methods for estimating cardiovascular risk in a cohort and to compare them with other risk scales. METHODS:We calculated cardiovascular risk by means of 15 machine-learning methods and using the SCORE and REGICOR scales and in 38 527 patients in the Spanis...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13389
更新日期：2019-10-01 00:00:00
abstract：:The aim of this study was to identify the aerobic and the anaerobic microorganisms which can be related to duct ectasia. The patients were divided into two groups. Group 1 comprised 100 patients with coloured nipple discharge (duct ectasia group), and Group 2 (the control group) was composed of 50 patients without nip...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2005.00619.x
更新日期：2005-09-01 00:00:00
abstract：:A drug utilisation review was carried out in the medical outpatient department of the Manipal teaching hospital, a tertiary care hospital in Pokhara, western Nepal, to determine the prescribing frequency of commonly used drugs. An attempt was made to relate prescription data to age and sex of the patients. A total of ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：AIMS:To examine whether the blood pressure (BP) profiles of lumiracoxib and high-dose ibuprofen differed in patients treated with different classes of antihypertensive medications. METHODS:A 4-week, multicentre, randomised, double-blind study has compared the effects of lumiracoxib 100 mg once daily (od) (n = 394) and...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1742-1241.2010.02346.x
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the Joint British Societies' (JBS 2) Factfile, cardiovascular risk assessment paper charts and electronic risk calculator posted to health professionals in general practice. DESIGN:Phase one: surveys on use of the JBS 2 charts and calculator; views on improving use and ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2009.02201.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:There has been a dramatic increase in the incidence of immediate breast reconstruction after mastectomy for breast cancer over the past few decades and autologous tissue flaps are being used with increasing frequency. Concern has been expressed that these complex procedures may lead to a delay in the deliver...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02199.x
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:The objectives of this study were to compare the performance indicators of risk-adjustment models based on administrative and clinical data in Korea, and to assess whether administrative data alone is useful for comparing quality of care. METHODS:Outcome was defined as death within 30 days of discharge. For ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1742-1241.2007.01345.x
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Antibiotics are widely used and inaccurate or inappropriate prescription of antibiotics causes a significant increase in the prevalence of multidrug-resistant bacterial infections among children. This research aimed to study antibiotic prescriptions in hospitalised paediatric patients and to determine the pr...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13782
更新日期：2020-10-24 00:00:00
abstract：:Despite efforts to diagnose and treat hypertension effectively, the goal of lowering blood pressure (BP) levels is rarely achieved, as treatment is often initiated with a single antihypertensive agent. The aim of this study was to assess the safety and efficacy of a first-line fixed-dose combination treatment compared...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1368-5031.2006.00841.x
更新日期：2006-03-01 00:00:00
abstract：:The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1742-1241.2004.00353.x
更新日期：2005-05-01 00:00:00
abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with gastrointestinal adverse effects, ranging from dyspepsia and peptic ulcer disease to more serious complications such as haemorrhage or perforation. NSAID-induced gastrointestinal toxicity is a significant medical problem worldwide. Misoprostol is effec...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2005.00660.x
更新日期：2005-10-01 00:00:00
