Abstract:
BACKGROUND:The available evidence regarding the possible effects of resveratrol on liver function is inconsistent. Therefore, the present meta-analysis was performed to investigate the overall effects of resveratrol supplementation on liver enzymes in adults. METHODS:A systematic and comprehensive search of the online medical databases including PubMed, Scupos, Web of Science and Cochran Library was performed up to February 2020. All RCTs using resveratrol supplements in adults were included in this systematic review and meta-analysis. The overall effect was presented as weighted mean difference (WMD) and 95% confidence interval (CI) in a random-effects meta-analysis model. RESULTS:Finally, 15 randomised trials including 714 participants were selected for the present meta-analysis. Pooled analysis did not show any significant changes in alanine aminotransferase (ALT) (WMD: 0 IU/L, 95% CI: -3.17 to 3.17, P = .99; I2 = 74.2%), aspartate aminotransferase (AST) (WMD: -2.40 IU/L, 95% CI: -5.45 to 0.65, P = .11; I2 = 82.9%), gamma-glutamyl transferase (GGT) (WMD: -1.26 IU/L, 95% CI: -4.64 to 2.13, P = .64; I2 = 23.7%), alkaline phosphatase (ALP) (WMD: 3.80 IU/L, 95% CI: -4.65 to 12.25, P = .37; I2 = 29.9%) and bilirubin (WMD: 0.13 IU/L, 95% CI: -0.43 to 0.17, P = .39; I2 = 8.9%) after supplementation with resveratrol. CONCLUSION:Overall, in our study, resveratrol does not affect liver enzyme levels significantly, but subgroup analysis indicates that these results may be influenced by resveratrol dose, duration of the study and population status, so future high-quality studies are necessary to get definitive results.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Darand M,Farrokhzad A,Ghavami A,Hadi A,Karimi E,Fadel A,Askari Gdoi
10.1111/ijcp.13692subject
Has Abstractpub_date
2020-08-31 00:00:00pages
e13692eissn
1368-5031issn
1742-1241pub_type
杂志文章abstract:AIMS:We prospectively enrolled 207 patients (121 were 75 or older and 86 younger than 75) who were admitted to three Respiratory Monitoring Units. The primary outcomes were intubation and mortality rates; the secondary outcomes were changes in arterial blood gases analysis, non-invasive ventilation (NIV) duration and l...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12484
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:It is undecided whether glucose control as advocated by the professional organisations and the glucose-lowering method by itself affects clinical outcome in patients with diabetes mellitus hospitalised in general medical wards. Our aim was to investigate whether a basal/bolus regimen and a modified prehospit...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2010.02384.x
更新日期:2010-12-01 00:00:00
abstract::Of the 25,000 new cases of breast cancer annually in the UK, at least half will develop metastases at some time. Approximately one-third of these will be hormone-sensitive and thus suitable for endocrine manipulation. Such patients may live for several years. Care should be patient-centred and evidence-based, with pri...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
abstract::We sought to clarify whether impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both (IFG/IGT) represent the most severe impairment in insulin resistance (IR) and insulin secretion. Among the 159 Chinese subjects, 21 were diagnosed as having IFG, 103 as having IGT and 35 as having both. IR and beta-ce...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2005.00494.x
更新日期:2005-06-01 00:00:00
abstract::Graham Jackson introduced the concept that erectile dysfunction was a marker for undiagnosed cardiovascular disease and future events. Unfortunately this had had modest impact on CVD management as ED is not incorporated into current risk calculators. In this paper, we examine recent evidence as to whether ED should be...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13054
更新日期:2018-02-01 00:00:00
abstract::A randomised, double-blind, parallel, placebo-controlled, 12-week study was carried out to evaluate the efficacy and safety of 20-mg tadalafil taken 'as needed' in a population of men with erectile dysfunction (ED) from Egypt and Turkey. One hundred and thirty-two patients were randomised in this study. Tadalafil was ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-1241.2006.00993.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:To evaluate state and trait form of anxiety and current depression in patients affected by gastrointestinal diseases. METHODS:We studied 1641 outpatients with gastrointestinal disorders, consecutively referred to our Internal Medicine outpatients from 1997 to 2005. State and trait anxiety were assessed by t...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2008.01763.x
更新日期:2008-07-01 00:00:00
abstract::A 60-year-old man noticed rapid enlargement of a long-standing thyroid goitre, with dysphagia and difficulty in breathing. Thyrotoxicosis was diagnosed. Chest X-ray revealed multiple pulmonary metastases. He underwent near-total thyroidectomy. The histopathology revealed an undifferentiated thyroid carcinoma with some...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:This study was designed to assess clinical and functional outcomes associated with switching to duloxetine treatment in patients with major depressive disorder (MDD) experiencing emotional and painful physical symptoms in their current episode. METHODS:In this 8-week, multinational, multicentre, single-arm,...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1742-1241.2010.02546.x
更新日期:2011-01-01 00:00:00
abstract:AIM:To raise awareness on nocturia disease burden and to provide simplified aetiologic evaluation and related treatment pathways. METHODS:A multidisciplinary group of nocturia experts developed practical advice and recommendations based on the best available evidence supplemented by their own experiences. RESULTS:Noc...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/ijcp.13027
更新日期:2017-11-01 00:00:00
abstract::A comparison was made between the accuracy of Ames and Boehringer reagent strips for detecting urinary tract infections in 100 elderly patients (50 acutely ill patients admitted to hospital and 50 attending the day hospital). The results for urinary nitrite, blood and protein for both strips were documented. Nitrite p...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Fracture of the penis can be managed conservatively or surgically. Conservative management is associated with a high morbidity, and early surgical repair of the fracture is usually recommended in order to prevent complications. Because a fractured penis is swollen throughout its length, it is difficult to identify the...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Despite huge advances in terms of the impact of antiretroviral therapy on HIV-related morbidity and mortality patients continue to fail therapy. We discuss the reasons why failure occurs including primary or transmitted resistance, poor adherence, toxicity and drug potency. We performed a review of PubMed, Medline and...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01383.x
更新日期:2007-06-01 00:00:00
abstract::People with genuine anxiety disorders can be misdiagnosed and mismanaged, because of negative public and professional attitudes to anxiety and the 'worried well'. Misdiagnosis includes not taking symptoms seriously and giving patients pejorative labels such as 'personality disorder' or 'inadequate'. This can lead to m...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::To investigate ethnic differences and the effect of age and education on awareness and attitudes of women towards hormone replacement therapy (HRT), we conducted a questionnaire survey of 180 women attending a gynaecology clinic, of whom 152 (84.4%) responded. Seventy-one of the women had heard of HRT. Awareness of HR...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:AIMS:The aims of this study were to determine the diagnostic yield of a dedicated heart failure diagnosis clinic and the impact of using different guideline recommended N-terminal pro B-type natriuretic peptide (NT-proBNP) referral thresholds on diagnosis and referral patterns. METHODS AND RESULTS:Patients referred by...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12694
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Tension-free vaginal tape obturator (TVT-O) and tension-free vaginal tape secur (TVT-S) are common surgeries for the treatment of stress urinary incontinence (SUI), several randomised controlled trials (RCTs) have compared the effects of TVT-O and TVT-S, yet the results remained inconsistent. Therefore, we a...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析
doi:10.1111/ijcp.13506
更新日期:2020-09-01 00:00:00
abstract::We report a case of acute myocardial infarction in an HIV-infected patient without significant coronary artery disease (CAD) risk factors. The patient underwent rescue percutaneous transluminal coronary angioplasty (PTCA), with a successful outcome. We presume a possible pathogenetic role of anti-retroviral therapy an...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2004.00246.x
更新日期:2005-03-01 00:00:00
abstract::Lithium salts have been used in medicine for over a century and are a widely accepted treatment. Clinical practice in the London borough of Barnet led us to suspect that agreed guidelines were not being followed. We checked them against published guidelines and followed up their implementation. A list of patients on l...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Anticoagulant therapy in patients with atrial fibrillation (AF) increases the risk of minor bleeding, which is mostly accepted by patients. We aimed to assess whether continuation of anticoagulation despite minor bleeding is associated with a higher level of knowledge on AF and anticoagulation. METHODS AND ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13483
更新日期:2020-06-01 00:00:00
abstract::TT virus (TTV) is a novel DNA virus that has been identified in patients with post-transfusional hepatitis of unknown aetiology. However, its pathogenic role in liver injury remains unclear. To determine its frequency and clinical impact in cryptogenic liver diseases, we investigated the TTV prevalence in patients wit...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Overactive bladder (OAB) syndrome has a diverse etiology that disrupts quality of life domains in affected patients. OAB is significantly under-recognised and undertreated, especially in the primary care setting. In order to educate primary care providers about OAB recognition, evaluation and management, we ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13604
更新日期:2020-11-01 00:00:00
abstract::Haematogenous metastases to the small bowel are a rare occurrence, usually from malignant melanoma or bronchogenic carcinoma. There are occasional reports of other primary tumours presenting with small bowel involvement as the first evidence of metastases. We describe a case of intraluminal jejunal metastasis from a r...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::The objective of this study was to investigate the impact of rivastigmine therapy on attention, apathy, anxiety and agitation in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting. Patients with mild-to-moderate AD were enrolled in the study by physicians across Canada. They were ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-1241.2007.01387.x
更新日期:2007-06-01 00:00:00
abstract:AIMS:We aimed to assess the prevalence, components and evolution of polypharmacy and to evaluate risk factors associated with polypharmacy. METHODS:A retrospective dynamic cohort study was performed, using a primary healthcare database comprising Flemish community-dwelling adults aged ≥40 years between 2011 and 2015. ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13942
更新日期:2020-12-19 00:00:00
abstract::Both the incidence of twin pregnancy and the demand for prenatal diagnosis are increasing. Unfortunately, biochemical screening and ultrasound scanning are less reliable for prenatal diagnosis in twin pregnancies than in singletons. Amniocentesis and chorionic villous biopsy are usually diagnostic in singleton pregnan...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Motor restlessness, characterised by an irresistible urge to move about, can be a manifestation of many underlying disorders. Unfortunately, it is often poorly recognised and underdiagnosed in clinical practice, possibly because patients do not seek medical attention, or their complaints were thought to be secondary t...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::Calcium dobesilate (Doxium) is used in the treatment of diabetic retinopathy. Clinical studies show a slowdown of the progression of the disease after long-term oral treatment. The main action of the drug is related to a reduction of microvascular permeability as measured by different parameters and methods (vitreous ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Snoring is a very common source of complaints from partners and neighbours. Snorers themselves are less likely to be affected, unless they have associated daytime sleepiness caused by the sleep disruption from obstructive sleep apnoea. There is increasingly firm evidence that obstructive sleep apnoea is associated wit...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2003-11-01 00:00:00
abstract::Twin reversed arterial perfusion (TRAP) syndrome is an extremely rare manifestation of feto-fetal transfusion syndrome. This condition is seen in monozygotic twin pregnancies, where the affected twin is perfused retrogradely by the healthy twin. The affected twin presents with bizarre malformations such as acardia and...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00