Abstract：
BACKGROUND:There is abundant evidence that patients with rheumatoid arthritis (RA) are at elevated cardiovascular (CV) risk. The contribution of lipids in general is well recognised, but is as yet unclear in inflammatory diseases such as RA in part because inflammation appears inversely associated with lipid levels in RA. METHODS:The CARRE study is a cohort study of 353 randomly selected RA outpatients followed since their enrollment in 2001-2002. We used data from this cohort to (i) evaluate the relationship at baseline between lipid levels [total cholesterol (TC), high-density lipoprotein (HDL)-cholesterol and the TC:HDLc ratio] and inflammation [by means of C-reactive protein (CRP)]; and (ii) determine the association of baseline TC and TC:HDLc ratio with incident (fatal and non-fatal) CV events. RESULTS:C-reactive protein correlated negatively with TC (r = -0.184, p = 0.002), more so with HDLc (r = -0.327, p = 0.001) and therefore positively with TC:HDLc ratio (r = 0.204, p = 0.001). These associations were most evident when CRP exceeded 10 mg/l. Furthermore, the TC:HDLc ratio, but not TC, was positively related to event risk, again most marked in those with elevated CRP. CONCLUSION:Our observations support use of TC:HDLc ratio rather than TC alone in assessing cardiovascular risk in RA patients, especially in those with high inflammatory activity.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Peters MJ,Voskuyl AE,Sattar N,Dijkmans BA,Smulders YM,Nurmohamed MTdoi
10.1111/j.1742-1241.2009.02220.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
1440-3issue
10eissn
1368-5031issn
1742-1241pii
IJCP2220journal_volume
64pub_type
杂志文章abstract：BACKGROUND:Smoking has important health and economic consequences for individuals and society. This study expands the understanding of work-related burden associated with smoking and benefit of smoking cessation across the US, European Union (EU) and China using large-scale, representative survey methodology. METHODS:...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12900
更新日期：2017-01-01 00:00:00
abstract：:A drug utilisation review was carried out in the medical outpatient department of the Manipal teaching hospital, a tertiary care hospital in Pokhara, western Nepal, to determine the prescribing frequency of commonly used drugs. An attempt was made to relate prescription data to age and sex of the patients. A total of ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:In the setting of an increasing workload for radiologists, this study focuses on the feasibility of skill mixing in breast imaging in a hospital radiology department. METHODS:Two radiological technologists with more than 10 years of experience in performing mammograms were trained in prereading mammograms to s...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2009.02310.x
更新日期：2010-03-01 00:00:00
abstract：AIMS:Studies of antimuscarinics for overactive bladder (OAB) typically use objective and subjective measures to assess efficacy, as each provides unique information about patient outcome. We evaluated the relationships between changes in diary-documented OAB symptoms and other patient-reported outcome (PRO) measures. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1742-1241.2010.02532.x
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Guidelines for injury care are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. We aimed to assess inter-hospital variation in surgical intensity for injury admissions and evaluate the correl...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13613
更新日期：2020-11-01 00:00:00
abstract：:The aim of this review was to outline current forms of surgical simulation and methods of assessing technical skills using these forms of simulation. To review this subject, a literature search was done using key words 'assessment', 'simulation', 'surgery', 'technical skills' and 'virtual reality'. Simulation in surge...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01435.x
更新日期：2007-12-01 00:00:00
abstract：:Manifestations of atypical gastroesophageal reflux disease (GORD) are varied, and the presentation of atypical symptoms may occur in the absence of typical symptoms. The most sensitive and specific investigation for GORD is pH monitoring, and its application in atypical disease is utilized throughout this paper as a b...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2004.0081.x
更新日期：2004-01-01 00:00:00
abstract：:Inflammatory pseudotumours of the liver are rare benign tumours of unknown origin, usually mistaken for malignant lesions. Two patients with Type 2 diabetes presented separately, unwell with fever, weight loss and hepatomegaly. Ultrasonography revealed 3-4 cm multiple lesions in the liver of the first case and a solit...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：AIMS:Arterial hypertension is a well-established factor for increased risk of cardiovascular diseases, but low admission blood pressure has also been suggested as predictor for increased mortality. We hypothesised that in patients with acute myocardial infarction admission blood pressure at the Emergency Department pre...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12588
更新日期：2015-08-01 00:00:00
abstract：:Hormone replacement therapy (HRT) leads to a similar annual increase in risk of breast cancer as does each extra year of remaining premenopausal. Taken for more than 10 years HRT leads to a 35% increase in risk of developing breast cancer. It does not increase a woman's risk of dying of breast cancer, and may improve ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：AIMS:Our goal was to determine the effect of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) consensus algorithm for the initiation and adjustment of type 2 diabetes (T2D) therapy, published in 2006, on the incidence of early metformin monotherapy (EMM), defined as ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2009.02319.x
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The impact of robot-assisted techniques versus conventional freehand techniques in terms of the accuracy of pedicle screw placement remains conflicting. This meta-analysis was performed to evaluate this relationship. METHODS:A systematic literature search up to July 2020 was performed and 15 studies were de...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13964
更新日期：2020-12-28 00:00:00
abstract：INTRODUCTION:Erectile dysfunction (ED) is common in older age and in diabetes mellitus (DM). Phosphodiesterase type 5-inhibitors (PDE5-is) are the first-line for ED. We investigated how the type of diabetes and age of males affect the PDE5-i use in the primary care setting. METHODS:From 2018 to 2019, the general pract...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13538
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Exhaustion is the perception of low energy. Little is known about how exhaustion persists, remits or reappears over time in patients with chronic obstructive pulmonary disease (COPD) or how to predict these events. We determined the likelihood of transitions between states of exhaustion and no ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13068
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Emerging research demonstrates an interrelationship between systemic inflammation, physical activity and premature all-cause mortality among chronic obstructive pulmonary disease (COPD) patients. Less common in this literature is the use of objective measures of physical activity and representative samples o...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12778
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:While physical activity (PA) is known to have positive effects on psychological and physical health, little is understood about the association between non-compensatory PA (ie, not compulsive or intended to control weight or shape) and psychopathology among individuals with eating-disorder features. The prese...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13401
更新日期：2019-11-01 00:00:00
abstract：:Serum prostate-specific antigen (PSA) measurement is used to investigate patients with lower urinary tract symptoms and to screen for prostatic malignancy in symptom-free males over 50 years of age. Approximately 60% of patients with early (prostate-confined) occult malignancy show increased serum PSA levels, as do so...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Overactive bladder (OAB) syndrome has a diverse etiology that disrupts quality of life domains in affected patients. OAB is significantly under-recognised and undertreated, especially in the primary care setting. In order to educate primary care providers about OAB recognition, evaluation and management, we ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13604
更新日期：2020-11-01 00:00:00
abstract：:Sarcoidosis is a chronic disease with an unknown aetiology. Our aim was to evaluate the pattern of seasonality of stage 1 sarcoidosis subjects who had symptoms by all cases, by age and by both genders. In this study, we used Roger's test for cyclic variation to prove that this seasonal variation was more than chance. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2005.00773.x
更新日期：2006-11-01 00:00:00
abstract：AIMS:To examine the relationship between costs of hyperglycaemia drug treatment and glycemic control amongst people with type 2 diabetes (T2D). METHODS:This observational study utilised data from the QUALIDIAB database on 3,452 T2D patients seen in Diabetes Centers in Argentina. Patients were classified according to t...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13336
更新日期：2019-04-01 00:00:00
abstract：AIMS:This was a post hoc analysis to determine whether baseline severity of depression influenced the efficacy of duloxetine in treating major depressive disorder (MDD) and to better characterise the symptom response profile for duloxetine in patients with mild, moderate or more severe depression. METHODS:Data were po...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2007.01444.x
更新日期：2007-08-01 00:00:00
abstract：:Despite potential benefits, primary care clinicians may avoid using antimuscarinics in men with overactive bladder (OAB) symptoms because of safety concerns. To review the efficacy and safety of antimuscarinics, alone or in combination with an α-blocker, for the treatment of men with OAB symptoms, we conducted a syste...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2010.02611.x
更新日期：2011-04-01 00:00:00
abstract：:Adult Indonesian outpatients were randomised to receive either valsartan 80 mg once daily or captopril 25 mg twice daily for 8 weeks. The main criterion for tolerability was the incidence of adverse events. The primary efficacy variable was the change in mean sitting diastolic blood pressure (SDBP) from baseline to en...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1999-06-01 00:00:00
abstract：AIM:We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS:Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.13022
更新日期：2017-12-01 00:00:00
abstract：:We performed the present study to compare patients with migraine and tension-type headache (TTH) in their behaviour during the attacks and the manoeuvres to relieve the pain. One hundred thirty consecutive patients with either migraine (n = 75) or TTH (n = 55) were questioned (including the use of a checklist) concern...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2005.00535.x
更新日期：2005-07-01 00:00:00
abstract：:The current study compared the effectiveness of the graduated tuning fork (128 Hz) and the neurothesiometer in assessing vibration sensation perception in patients presenting with type II diabetes mellitus. A quota sample of patients (n = 21; age range 43-73 years) were assessed using the neurothesiometer and tuning f...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2005.00650.x
更新日期：2006-02-01 00:00:00
abstract：:In this journal, Cummins et al reported an experiment that examined clinicians' predictions of causes of death from subjects' pre-morbid photographs. They found that clinicians performed at chance. The validity of two of their other conclusions are challenged. First, that clinicians routinely form impressions of how a...
journal_title：International journal of clinical practice
pub_type： 评论,杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Macrolide anti-bacterials are widely used for the empirical treatment of lower respiratory tract infections (RTIs) due to their activity against Streptococcus pneumoniae and other common respiratory pathogens and good safety/tolerability profile. However, the prevalence of macrolide resistance, particularly pneumococc...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2004.00152.x
更新日期：2004-08-01 00:00:00
abstract：:After more than 20 years, the conflict of interest (COI) movement has failed to substantiate its central claim that interactions between physicians, researchers and the medical products industry cause physicians to make clinical decisions that are adverse to the best interests of their patients. The COI movement's ins...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12366
更新日期：2014-06-01 00:00:00
abstract：:Fracture of the penis can be managed conservatively or surgically. Conservative management is associated with a high morbidity, and early surgical repair of the fracture is usually recommended in order to prevent complications. Because a fractured penis is swollen throughout its length, it is difficult to identify the...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
