Abstract：
:The potential effect of orlistat on cardiovascular co-morbidities may have been previously underestimated. This study assesses the efficacy of orlistat therapy for weight loss and cardiovascular risk factor reduction in obese patients with cardiovascular risk. This was a 54-week, double-blind, randomised, placebo-controlled, parallel group study with 531 patients being randomised. Mean weight loss was significantly greater with orlistat than with placebo (5.8% vs 2.3%; p<0.0001). Orlistat was also associated with significantly greater improvements than placebo in diastolic BP (-5.5 vs -3.1 mmHg; p<0.01), systolic blood pressure (-6.0 vs -2.3 mmHg; p<0.01), oral glucose tolerance test (-0.37 vs +0.09 mmol/l; p<0.05), fasting glucose (-0.19 vs +0.06 mmol/l; p<0.05), total cholesterol (-1.31% vs +3.78%; p<0.0001), LDL-cholesterol (-7.09% vs -0.55%; p<0.0001) and waist circumference (-5.99 vs -2.60 cm; p<0.0001). Orlistat was well tolerated. Orlistat weight loss is associated with improvements in cardiovascular co-morbidities, and hence cardiovascular risk.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Broom I,Wilding J,Stott P,Myers N,UK Multimorbidity Study Group.subject
Has Abstractpub_date
2002-09-01 00:00:00pages
494-9issue
7eissn
1368-5031issn
1742-1241journal_volume
56pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:Buprenorphine is a semi-synthetic opioid derived from thebaine. The transdermal formulation of buprenorphine has been available in Belgium for 3 years, during which time the Pain Clinic of the St Elisabeth of Verviers Hospital has gained experience in the use of transdermal buprenorphine for the treatment of moderate-...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.01109.x
更新日期：2006-10-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Persistence with antimuscarinic (AM) drugs prescribed for overactive bladder (OAB) is poor. This study aimed to compare persistence and adherence with the beta-3-adrenoceptor agonist mirabegron (MIR) vs AMs over 12 months. PATIENTS AND METHODS:This retrospective cohort analysis included pat...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12996
更新日期：2017-10-01 00:00:00
abstract：:Cardiovascular diseases are the principal causes of mortality in middle-aged people and in older people. Coronary heart disease (CHD) is the most common of the cardiovascular diseases; high serum levels of cholesterol are associated with atherosclerosis and an increased risk of CHD. Cholesterol homeostasis is achieved...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2004.00351.x
更新日期：2004-09-01 00:00:00
abstract：:Fever of unknown origin (FUO) is a clinical dilemma in western countries and in China. To investigate the causes and prognosis of FUO, 208 patients with FUO admitted to a large university hospital in China were investigated. The final diagnoses established in 158 cases (75.96%) were: infectious disease in 66 cases (31...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：AIMS:Early clinical trials suggest that blood-derived stem/progenitor cells (including peripheral blood-derived stem cells and circulating progenitor cells) may have a positive impact on patients with ischaemic heart disease (IHD). The therapeutic effects of these cells remain unclear, considering the inconsistent resu...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2011.02715.x
更新日期：2011-08-01 00:00:00
abstract：:The objective of this study was to investigate the impact of rivastigmine therapy on attention, apathy, anxiety and agitation in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting. Patients with mild-to-moderate AD were enrolled in the study by physicians across Canada. They were ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1742-1241.2007.01387.x
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:'Do Not Attempt Cardiopulmonary Resuscitation' (DNACPR) orders are made frequently for older people in hospital. Sensitive anticipatory discussion is encouraged where possible, but usually this does not happen, despite the evidence suggesting that many older patients would like to be involved in such decisio...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12067
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Emerging research demonstrates an interrelationship between systemic inflammation, physical activity and premature all-cause mortality among chronic obstructive pulmonary disease (COPD) patients. Less common in this literature is the use of objective measures of physical activity and representative samples o...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12778
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Stroke risk is heightened among patients who have had a primary stroke or transient ischaemic attack (TIA). The primary care physician is in the best position to monitor these patients for stroke recurrence. Because stroke recurrence can occur shortly after the primary event, guidelines recommend initiating ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01515.x
更新日期：2007-10-01 00:00:00
abstract：:Nitrates are useful drugs in cardiovascular medicine. They have a presumed vasovagal effect, which is a rare but often under-recognised complication that is partly caused by central inhibition of the sympathetic nervous system. However, no consistent variable associated with the presumed vasovagal effects following ni...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:This study was to evaluate the efficacy and safety of ibutilide and propafenone given intravenously in converting recent onset atrial fibrillation (AF). Eighty-two consecutive patients with AF (onset in 2 h to 90 days) were randomly assigned to receive two 10-min infusions, 10 min apart, of either ibutilide (1 mg) or ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1368-5031.2005.00705.x
更新日期：2005-12-01 00:00:00
abstract：:The aim of this study was to review the application of antimicrobial stewardship principles to the management of community-acquired pneumonia (CAP). Data from 14 published clinical studies, meta-analyses and practice guidelines regarding the application of antimicrobial stewardship strategies to the management of CAP ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2011.02704.x
更新日期：2011-07-01 00:00:00
abstract：:A case of a child with acute cerebellar ataxia associated with chickenpox virus infection is described. Acute cerebellar ataxia associated with chickenpox is a well-recognised complication and the pertinent features of this condition are discussed. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is the leading cause of adult blindness among individuals aged 50 and older in the Western world, with the neovascular form of AMD responsible for the most severe and rapid visual loss. Although monotherapy with currently available treatments can slow the rate of loss of vision i...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01299.x
更新日期：2007-03-01 00:00:00
abstract：:Fluid in the pleural space is a common sequela of a wide range of diseases which may be pulmonary, pleural or extrapulmonary. As the differential diagnosis is wide, a systematic approach to investigation and diagnosis is recommended. This review highlights the important features and recommendations for the investigati...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02068.x
更新日期：2009-11-01 00:00:00
abstract：AIMS:Studies of antimuscarinics for overactive bladder (OAB) typically use objective and subjective measures to assess efficacy, as each provides unique information about patient outcome. We evaluated the relationships between changes in diary-documented OAB symptoms and other patient-reported outcome (PRO) measures. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1742-1241.2010.02532.x
更新日期：2011-02-01 00:00:00
abstract：AIMS:To analyse the predictive capacity of 15 machine learning methods for estimating cardiovascular risk in a cohort and to compare them with other risk scales. METHODS:We calculated cardiovascular risk by means of 15 machine-learning methods and using the SCORE and REGICOR scales and in 38 527 patients in the Spanis...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13389
更新日期：2019-10-01 00:00:00
abstract：:Acid suppressive therapy, in the form of proton pump inhibitor (PPI), is widely used in cirrhotic patients, often in indications which are not clearly justified. PPI facilitates enteric bacterial colonisation, overgrowth and translocation, which might predispose to spontaneous bacterial peritonitis. However, observati...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2011.02650.x
更新日期：2011-06-01 00:00:00
abstract：:Omalizumab, a recombinant, humanised monoclonal antibody against human IgE, will be introduced soon for the treatment of allergic asthma. This antibody binds circulating IgE molecules and inhibits the type I immune response in the lung and other target organs. In the phase II and III studies performed, it demonstrated...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:A 60-year-old man noticed rapid enlargement of a long-standing thyroid goitre, with dysphagia and difficulty in breathing. Thyrotoxicosis was diagnosed. Chest X-ray revealed multiple pulmonary metastases. He underwent near-total thyroidectomy. The histopathology revealed an undifferentiated thyroid carcinoma with some...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:To describe the efficacy and safety of asenapine for the treatment of schizophrenia and bipolar disorder. DATA SOURCES:The pivotal registration trials were accessed by querying http://www.pubmed.gov, http://www.fda.gov and http://www.clinicaltrials.govfor the search terms 'asenapine' or 'ORG 5222'. STUDY SE...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2009.02228.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND/AIMS:The consumption of soft drinks has increased considerably during the last decades. Among them, the cola-based preparations are possibly the refreshments with the largest sales worldwide. In addition to the possible detrimental effects of moderate, chronic cola consumption, it has been proposed that the ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02051.x
更新日期：2009-06-01 00:00:00
abstract：:The phenomenon of spontaneous remission is one of the less well known aspects of the leukaemias. Spontaneous remission has been reported in both acute and chronic leukaemia. The mechanism is unclear but may involve immune modulation related to an intercurrent infection or transfusion of blood products. We present a ra...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：AIMS:Intervention studies have shown that angiotensin receptor blockers (ARB) may reduce the incidence of type 2 diabetes mellitus. It is currently unclear whether short-term therapy with ARBs affects metabolic parameters. METHODS:i-RESPOND, a randomised, controlled, multicentre, double-blind study evaluated the effec...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1742-1241.2009.02246.x
更新日期：2010-01-01 00:00:00
abstract：:Serum prostate-specific antigen (PSA) measurement is used to investigate patients with lower urinary tract symptoms and to screen for prostatic malignancy in symptom-free males over 50 years of age. Approximately 60% of patients with early (prostate-confined) occult malignancy show increased serum PSA levels, as do so...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To assess the relationship between high-definition optical coherence tomography (HD-OCT) and scanning laser polarimetry (SLP) with variable (VCC) and enhanced (ECC) corneal compensation in measuring peripapillary retinal nerve fibre layer (RNFL) thickness in healthy eyes and those with early-to-moderate glaucom...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2011.02649.x
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Substantial residual cardiovascular risk persists despite effective LDL lowering treatment in populations at elevated risk for adverse cardiovascular outcomes. Low HDL cholesterol is an independent cardiovascular risk factor and occurs in about one-third of patients treated for dyslipidaemia in Europe. Moreo...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01514.x
更新日期：2007-11-01 00:00:00
abstract：:Headache is frequently reported as one of the neurological manifestations of essential thrombocythaemia (ET) and other myeloproliferative neoplasms. It is associated with considerable morbidity; yet, it is a frequently under-recognised symptom. In patients with ET, headaches may be attributable to the disease, to the ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2012.02986.x
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To investigate the accuracy of three non-invasive blood pressure (BP) devices in atrial fibrillation (AF) compared with invasive arterial BP. METHODS:One hundred patients aged 45-90 years, 63% male (50 in AF and 50 age matched controls in sinus rhythm [SR]) were identified with arterial lines measuring beat-...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13410
更新日期：2019-08-29 00:00:00
abstract：:We report a case of Pott's puffy tumour in a 12-year-old. Owing to the late development of the frontal sinuses, frontal sinus infection in children is rare. When present it can lead to osteomyelitis associated with forehead swelling. Early diagnosis and active treatment prevent progression to life-threatening intracra...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
