Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates?

Abstract:

:The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6 hourly) or placebo till either maximum 10 days treatment or FEF (150 ml/kg/day) was reached. A standardised regimen guided enteral feeding. Demographic characteristics of enrolled neonates (CMC, placebo: n = 35) were comparable. Median (interquartile range) gestational age and birth weight were 29 (28, 30) vs. 29 (27, 31) weeks and 1090 (905, 1390) vs. 1236 g (928, 1565) for the CMC and placebo groups, respectively. Median (interquartile range) time to reach FEF was 5 (4, 6) vs. 5 (3, 8) days for CMC and placebo group, respectively (p = 0.5). No CMC-related adverse effects occurred. Prophylactic CMC did not have a significant role in reducing time to reach FEF.

journal_name

Int J Clin Pract

authors

Patole SK,Muller R

doi

10.1111/j.1742-1241.2004.00353.x

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

544-8

issue

5

eissn

1368-5031

issn

1742-1241

pii

IJCP353

journal_volume

59

pub_type

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