Abstract:
BACKGROUND:Substantial residual cardiovascular risk persists despite effective LDL lowering treatment in populations at elevated risk for adverse cardiovascular outcomes. Low HDL cholesterol is an independent cardiovascular risk factor and occurs in about one-third of patients treated for dyslipidaemia in Europe. Moreover, randomised intervention studies have shown that increasing HDL cholesterol improves cardiovascular outcomes. Correcting low HDL cholesterol therefore presents a rational and proven strategy for intervention to produce further reductions in cardiovascular risk beyond those possible with a statin alone. Nicotinic acid (niacin in the USA) is the most effective agent currently available for increasing levels of HDL cholesterol. OVERALL STUDY RESULTS:A once-daily, prolonged-release formulation of nicotinic acid (Niaspan) is as effective on HDL cholesterol as the immediate-release formulation, and is equally effective at increasing HDL cholesterol whether or not patients are already taking a statin. Niaspan also shares the antiatherogenic benefit of nicotinic acid, and induced regression of atherosclerosis in patients with cardiovascular disease during a period of treatment of up to 2 years. The incidence of flushing, the principal side effect of nicotinic acid, is lower with Niaspan than with immediate-release nicotinic acid. Simple practical measures are available to minimise the incidence and impact of flushing, including careful dose titration and avoiding hot or spicy foods near the time of ingestion of Niaspan. The potential for hepatotoxicity, muscle toxicity or marked exacerbation of hyperglycaemia in diabetes with Niaspan is very low, with or without concomitant statin treatment. CONCLUSION:Niaspan provides a practical means of delivering the cardioprotective benefits associated with correction of low HDL cholesterol.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Vogt A,Kassner U,Hostalek U,Steinhagen-Thiessen Edoi
10.1111/j.1742-1241.2007.01514.xsubject
Has Abstractpub_date
2007-11-01 00:00:00pages
1914-21issue
11eissn
1368-5031issn
1742-1241pii
IJCP1514journal_volume
61pub_type
杂志文章,评审abstract:AIMS:To investigate the association between the self-perception period of OAB symptoms (SP-OAB) and the overactive bladder symptom score (OABSS), along with related sociodemographic and lifestyle factors. METHODS:This was a cross-sectional study comprised of 192 men aged 40 years and older who participated in a prosta...
journal_title:International journal of clinical practice
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abstract:AIMS:To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia. METHODS:A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treat...
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journal_title:International journal of clinical practice
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abstract:BACKGROUND:Invasive meningitis and pneumonia caused by Haemophilus influenzae type b (Hib) is an important cause of childhood mortality in countries where Hib vaccination is not routine. We evaluated the non-inferiority of a licensed Hib vaccine, PRP-CRM(197) compared with a second licensed Hib vaccine, PRP-T, followin...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of clinical practice
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of clinical practice
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更新日期:2006-08-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2004-12-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-05-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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更新日期:2015-06-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00