Abstract：
:Current therapy in Russia for long-term management of asthma is mainly non-steroidal. This provided the opportunity to compare the efficacy and safety of formoterol (Oxis) Turbuhaler plus budesonide (Pulmicort) Turbuhaler with budesonide Turbuhaler alone in adults (n=338) with mild to moderate asthma who had little previous exposure to inhaled corticosteroids. The 12-week study followed a randomised, double-blind, parallel group design and included an open control group of patients who were treated with conventional non-corticosteroid therapy. Patients treated with formoterol plus budesonide benefited from a significantly greater improvement in their pulmonary function and asthma symptoms compared with budesonide alone (95% Cl of difference in mean morning peak expiratory flow [PEF] 8.7-36.3 l/min, p=0.0015). Non-corticosteroid treatment was significantly less effective than formoterol plus budesonide and budesonide alone (95% CIs of differences in mean morning PEF were 36.4-63.6 l/min and 14.1-41.1 l/min, respectively, both p=0.0001). Although the incidence and frequency of adverse events was not significantly different between the groups, formoterol plus budesonide and budesonide alone were better tolerated than non-corticosteroid treatment, and there were fewer incidences of asthma deterioration. Overall, formoterol Turbuhaler plus budesonide Turbuhaler was the safest and most effective treatment.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Chuchalin AG,Ovcharenko SI,Goriachkina LA,Sidorenko IV,Tsoi AN,Epoch Study Group.subject
Has Abstractpub_date
2002-01-01 00:00:00pages
15-20issue
1eissn
1368-5031issn
1742-1241journal_volume
56pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:The impact of robot-assisted techniques versus conventional freehand techniques in terms of the accuracy of pedicle screw placement remains conflicting. This meta-analysis was performed to evaluate this relationship. METHODS:A systematic literature search up to July 2020 was performed and 15 studies were de...
journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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pub_type： 杂志文章,meta分析
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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journal_title：International journal of clinical practice
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
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journal_title：International journal of clinical practice
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更新日期：2000-06-01 00:00:00
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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