Abstract：
BACKGROUND/AIMS:Simple compound of Helicobacter pylori eradication therapy may improve drug compliance of patients. The aims of this study were to compare the efficacy and tolerability of a simple combination containing levofloxacin 7-day once-daily with standard twice-daily triple therapy. PATIENTS AND METHODS:This was a prospective, randomised, open-label trial. A total of 189 consecutive patients diagnosed with peptic ulcer and H. pylori infection were enrolled. Patients were randomly divided into two groups: LEC group--levofloxacin 500 mg, esomeprazole 40 mg and clarithromycin 500 mg once daily for 7 days; AEC group--amoxicillin 1 g, esomeprazole 40 mg and clarithromycin 500 mg twice daily for 7 days. RESULTS:There were 90 patients in the LEC group and 99 patients in the AEC group. By intention-to-treat and per-protocol analysis, the H. pylori eradication rate was 78.9% [71/90; 95% confidence interval (CI), 70.3-87.5%] and 83.5% (71/85; 95% CI, 75.5-91.6%) respectively, in the LEC group; and 74.8% (74/99; 95% CI, 66.0-83.5%) and 86.0% (74/86; 95% CI, 78.6-93.5%) respectively, in the AEC group. The incidence and tolerability of side effects were similar between these two groups. CONCLUSION:The efficacy and tolerability of once-daily levofloxacin-containing triple therapy are equal to those of the standard twice-daily triple therapy in this study. However, none of the treatment regimens evaluated achieved enough eradication efficacies to be considered as a recommendable first-line treatment.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Chen LW,Chien RN,Chang JJ,Fang KM,Chang LCdoi
10.1111/j.1742-1241.2010.02482.xsubject
Has Abstractpub_date
2010-10-01 00:00:00pages
1530-1534issue
11eissn
1368-5031issn
1742-1241journal_volume
64pub_type
杂志文章,随机对照试验abstract：AIM:Real-life studies are needed to confirm the clinical relevance of findings from randomised controlled trials (RCTs). This study aimed to assess the effectiveness and tolerability of vildagliptin add-on vs. other oral antihyperglycaemic drugs (OADs) added to OAD monotherapy in a real-life setting, and to explore the...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.12252
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:In late December 2019 and on 1st January 2020, the coronavirus (COVID-19) infecting humans was first identified in Wuhan, Hubei Province, China. Later cases have also been confirmed worldwide. Coronaviruses are RNA viruses that are phenotypically and genotypically diverse. Globally, as of 6th April 2020, lab...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.13637
更新日期：2020-11-01 00:00:00
abstract：AIM:Real-world data on treatment patterns/outcomes in patients with advanced melanoma, while scarce, are useful for health technology assessments that govern patient access in many countries. We collected retrospective data on treatment patterns among patients in France, Germany and the UK with Stage IIIB/IIIC melanoma...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12946
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:It is undecided whether glucose control as advocated by the professional organisations and the glucose-lowering method by itself affects clinical outcome in patients with diabetes mellitus hospitalised in general medical wards. Our aim was to investigate whether a basal/bolus regimen and a modified prehospit...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2010.02384.x
更新日期：2010-12-01 00:00:00
abstract：:Both hepatitis B and hepatitis C are spread parenterally. Chronic hepatitis C is fast becoming the leading indication for liver transplantation. Most infected patients go on to develop chronic hepatitis, with approximately 20% developing liver cirrhosis or hepatocellular carcinoma after 20 years. Standard treatment no...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:Restrictions imposed for the COVID-19 pandemic and the people's fear of getting infected have caused a significant drop in the number of emergency service admissions. Herein, we aimed to investigate the reflections of our otherwise crowded emergency services' quietness in the period of normalisation. METHODO...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13912
更新日期：2021-02-01 00:00:00
abstract：:The aim of this study was to audit the preoperative administration of regular cardiac medication in general surgical patients and to determine if this can be improved with simple ward-based education. The notes and drug charts of 102 general surgical adult inpatients undergoing elective operations were analysed prospe...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.01002.x
更新日期：2006-10-01 00:00:00
abstract：:The role of low-density lipoprotein in the development of coronary heart disease (CHD) is well recognised. There is also growing evidence that high-density lipoprotein cholesterol (HDL-C) is a powerful inverse predictor for premature CHD and that maintaining a high HDL-C level may guard against atherosclerosis. Patien...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:The available evidence regarding the possible effects of resveratrol on liver function is inconsistent. Therefore, the present meta-analysis was performed to investigate the overall effects of resveratrol supplementation on liver enzymes in adults. METHODS:A systematic and comprehensive search of the online...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13692
更新日期：2020-08-31 00:00:00
abstract：:Overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology of heart failure (HF) and chronic kidney disease (CKD). RAAS antagonists can significantly improve clinical outcomes, but monotherapy blocks but one step of the RAAS and can be bypassed through compensatory mechanis...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.12803
更新日期：2016-07-01 00:00:00
abstract：:The role of clinician educators (CEs) in institutions and medical centres continues to be vital without any doubt. Although there has been more than a century since Sir William Osler established the role of the CE and the tradition by encouraging bed-side teaching, there is still a lack of consensus on the attributes ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2011.02780.x
更新日期：2011-11-01 00:00:00
abstract：IMPORTANCE:There is an ever-increasing drive to improve surgical patient outcomes. Given the benefits which robotics has bestowed upon a wide range of industries, from vehicle manufacturing to space exploration, robots have been highlighted by many as essential for continued improvements in surgery. OBJECTIVE:The goal...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.12492
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:Vardenafil has demonstrated efficacy for the pharmacological management of erectile dysfunction (ED). Accumulating evidence suggests that ED is frequently associated with underlying cardiovascular and metabolic conditions which are thought to be involved in the aetiology of ED. The present review aims to summ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2008.01852.x
更新日期：2008-10-01 00:00:00
abstract：AIMS:The aim of this study was to assess patient characteristics, medication treatment patterns and healthcare resource utilization among men with existing erectile dysfunction (ED) or benign prostatic hyperplasia (BPH), who are newly diagnosed with the second condition (BPH or ED) compared with those with only one con...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12657
更新日期：2015-08-01 00:00:00
abstract：:Tumour markers are used for diagnosis, staging, evaluation of response to treatment, prognosis and detection of recurrences in clinical oncology. In this study, we aim to investigate the levels of insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-III in cases with oesophageal carcinoma. We investigate...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.00854.x
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Ageing is intrinsically associated with a progressive decline in cardiorespiratory fitness (CRF) as measured by peak oxygen uptake (VO2peak ). Improving CRF through physical activity contribute to better and healthy ageing. High-intensity interval training (HIIT) is a potent method of improving CRF among sen...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析
doi：10.1111/ijcp.13490
更新日期：2020-06-01 00:00:00
abstract：:In this review, we discuss right-sided heart valve disease, namely tricuspid regurgitation (TR), tricuspid stenosis, pulmonary regurgitation, pulmonary stenosis and right-sided endocarditis. These are frequently seen in conjunction with other diseases, making assessment of their significance more difficult, but it has...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12485
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to describe the occurrence, angulation and mesialisation ratio of the ectopic eruption of the maxillary permanent first molar (PFM) and its correlation with the pathological resorption of maxillary primary second molar (PSM). METHODS:This retrospective study was performed using the ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13880
更新日期：2020-12-07 00:00:00
abstract：:For further improvement of coronary heart disease (CHD) management large epidemiological studies are required to characterise the real population of patients with CHD, treated in the primary care settings, and to evaluate how the guidelines are implemented in the everyday clinical practice. The aim of the Angina Treat...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1742-1241.2004.00234.x
更新日期：2004-12-01 00:00:00
abstract：:Spontaneous tumour lysis syndrome (STLS) inducing acute uric acid nephropathy, a rare and neglected disease, presents more insidiously than conventional post-treatment tumour lysis syndrome. Although STLS is a serious and potentially fatal complication in patients with neoplastic disorders, few investigations have add...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:Tissue inflammation has been linked to cancer in several disease models. We tested the association between chronic inflammation and prostate cancer (PCa), as well as high-grade prostatic intraepithelial neoplasia (HGPIN), in prostatic needle biopsy specimens. Tissues from 4526 men, who underwent systematic ultrasound-...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.00905.x
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Although the relationship of elevated serum uric acid levels and cardiovascular disease has been established in a great number of studies, the causal relevance of this finding remains ambiguous. An approach to evaluate the causal relevance of biomarkers is to exploit the natural randomised allocation of alle...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.13048
更新日期：2018-01-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the impact of depression and somatic symptoms on treatment outcomes in Korean male patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) attending a routine clinical practice. METHODS:This was a 12-week prospective observational study (n = 80). The Korean ve...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12340
更新日期：2014-04-01 00:00:00
abstract：:Better understanding of the immunopathogenesis of rheumatoid arthritis over the past few decades has promoted the innovation of new therapeutic approaches targeting the disease more specifically. In addition, refinements in the non-steroidal anti-inflammatory drugs (NSAID) may offer advantages for patients with RA. Th...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumferen...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12041
更新日期：2013-03-01 00:00:00
abstract：:Indiplon is a novel non-benzodiazepine sedative-hypnotic that modulates the GABAA receptor complex. It appears to be more selective for the alpha1-receptor subunit, associated with sedation, than other hypnotics. Two different formulations of indiplon have been developed: an immediate release (IR) version targeting sl...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2007.01322.x
更新日期：2007-06-01 00:00:00
abstract：AIM:To determine the prevalence of computer vision syndrome (CVS) and ergonomic practices among students in the Faculty of Medical Sciences at The University of the West Indies (UWI), Jamaica. METHOD:A cross-sectional study was done with a self-administered questionnaire. RESULTS:Four hundred and nine students partic...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13035
更新日期：2018-01-01 00:00:00
abstract：AIMS:Many tachy-brady syndrome (TBS) patients, are implanted a permanent pacemaker (PPM) to allow continuation of anti-arrhythmic drug (AAD) therapy to maintain sinus rhythm. Many of these PPM's are implanted as a preventive measure, in absence of symptomatic bradycardia. Our primary aim was to evaluate pacing use amon...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13583
更新日期：2020-10-01 00:00:00
abstract：AIMS:Studies of antimuscarinics for overactive bladder (OAB) typically use objective and subjective measures to assess efficacy, as each provides unique information about patient outcome. We evaluated the relationships between changes in diary-documented OAB symptoms and other patient-reported outcome (PRO) measures. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1742-1241.2010.02532.x
更新日期：2011-02-01 00:00:00
abstract：:Major concerns remain about the reliability of tympanic thermometers. The aim of this study was to investigate the agreement between rectal and tympanic thermometry and compare this with the repeatability of each method in patients with acute stroke. Tympanic temperature readings were from 0.7 degrees C below to 0.8 d...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
