Abstract:
BACKGROUND:Although the relationship of elevated serum uric acid levels and cardiovascular disease has been established in a great number of studies, the causal relevance of this finding remains ambiguous. An approach to evaluate the causal relevance of biomarkers is to exploit the natural randomised allocation of allelic variation in genes affecting their level, also known as Mendelian randomisation. AIM:The aim of this paper is to review the current literature regarding serum uric acid levels and cardiovascular and renal disease risk in Mendelian randomisation studies. METHODS:PubMed and Scopus databases were searched to retrieve Mendelian studies regarding uric acid, hyperuricaemia and cardiovascular risk. CONCLUSIONS:Genetic evidence based on conventional and novel Mendelian randomisation approaches suggest a modest, if any, causal effect of serum uric acid concentration on the development of cardiovascular disease, suggesting that further study of uric acid genes is needed in order to elucidate the relationship of serum uric acid levels and cardiovascular disease.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Kei A,Koutsouka F,Makri A,Elisaf Mdoi
10.1111/ijcp.13048subject
Has Abstractpub_date
2018-01-01 00:00:00issue
1eissn
1368-5031issn
1742-1241journal_volume
72pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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