Uric acid and cardiovascular risk: What genes can say.

Abstract:

BACKGROUND:Although the relationship of elevated serum uric acid levels and cardiovascular disease has been established in a great number of studies, the causal relevance of this finding remains ambiguous. An approach to evaluate the causal relevance of biomarkers is to exploit the natural randomised allocation of allelic variation in genes affecting their level, also known as Mendelian randomisation. AIM:The aim of this paper is to review the current literature regarding serum uric acid levels and cardiovascular and renal disease risk in Mendelian randomisation studies. METHODS:PubMed and Scopus databases were searched to retrieve Mendelian studies regarding uric acid, hyperuricaemia and cardiovascular risk. CONCLUSIONS:Genetic evidence based on conventional and novel Mendelian randomisation approaches suggest a modest, if any, causal effect of serum uric acid concentration on the development of cardiovascular disease, suggesting that further study of uric acid genes is needed in order to elucidate the relationship of serum uric acid levels and cardiovascular disease.

journal_name

Int J Clin Pract

authors

Kei A,Koutsouka F,Makri A,Elisaf M

doi

10.1111/ijcp.13048

subject

Has Abstract

pub_date

2018-01-01 00:00:00

issue

1

eissn

1368-5031

issn

1742-1241

journal_volume

72

pub_type

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