The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis.

Abstract:

:A 43-year-old female patient with Basedow-Graves' disease developed agranulocytosis in the eighth month of propylthiouracil therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF), a human haematopoietic growth factor, were started. Her granulocyte count returned to normal with the second dose of G-CSF, and ulcerating pharyngitis improved rapidly. We think that in patients with propylthiouracil-induced agranulocytosis, G-CSF will reduce the risk and severity of infection, and should be accepted as a part of the standard therapy.

journal_name

Int J Clin Pract

authors

Altunbas H,Yazicioglu G,Balci MK,Karayalçin U,Undar L

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

396-7

issue

5

eissn

1368-5031

issn

1742-1241

journal_volume

53

pub_type

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