Indiplon: the development of a novel therapy for the treatment of sleep onset and sleep maintenance insomnia.

abstract：:Ranitidine is one of the widely prescribed H2 receptor antagonists in the treatment of peptic ulcer. It is well tolerated and has few side-effects. Vasculitic rash occurring in association with ranitidine has been described. We report a case of a 39-year-old man who developed a purpuric rash, polyarthritis, abdominal ...

journal_title：International journal of clinical practice

authors： Prajapati C,Casson IF

更新日期：1997-06-01 00:00:00

abstract：:Although uric acid (UA) is considered as an antioxidant, the relationship between serum UA levels and cardiovascular diseases is not clear yet. Higher brachial artery resting diameter (BD), impaired brachial artery flow-mediated dilatation (FMD), increased carotid intima-media thickness (IMT), decreased aortic distens...

journal_title：International journal of clinical practice

authors： Erdogan D,Gullu H,Caliskan M,Yildirim E,Bilgi M,Ulus T,Sezgin N,Muderrisoglu H

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Whilst core curricula in neurology are nationally standardised, in real-world clinical practice, different approaches may be taken by individual consultants. The aims of this study were to investigate differences by assessing: (a) variance in diagnostic and investigative practice, using a case-based analysis of...

journal_title：International journal of clinical practice

authors： Aitchison C,Blackburn DJ,Khan A,Grünewald RA,Jenkins TM

更新日期：2020-11-12 00:00:00

abstract：:This study explored the characteristics associated with the use of self-care products and practices by people rehabilitating from stroke. A cross-sectional sub-study of the Sax Institute's 45 and Up Study in which 1300 participants who had indicated a doctor had diagnosed them as having had a stroke were mailed a sub-...

journal_title：International journal of clinical practice

authors： Sibbritt D,Steel A,Peng W,Adams J

更新日期：2020-11-07 00:00:00

abstract：AIMS:The association between inhaled corticosteroid (ICS) use and pulmonary tuberculosis (TB) development is uncertain. We conducted a population-based case-control study to investigate whether ICS use increases the risk of developing TB. METHODS:Tuberculosis patients aged 18 years and older were identified using the ...

journal_title：International journal of clinical practice

authors： Chung WS,Chen YF,Hsu JC,Yang WT,Chen SC,Chiang JY

更新日期：2014-10-01 00:00:00

abstract：:This randomised, crossover study compared the efficacy, safety, acceptability and patient preference of two multidose powder inhalers (MDPIs)--beclomethasone dipropionate Easyhaler (BDP-EH) and budesonide Turbohaler (BUD-TH)--in 79 stable asthmatics who used inhaled steroids but had no experience of MDPIs. After eight...

journal_title：International journal of clinical practice

authors： Jäger L,Laurikainen K,Leinonen M,Silvasti M

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term clinical and economic outcomes of biphasic insulin aspart 70/30 (BIAsp 70/30) treatment vs. insulin glargine in insulin naïve, type 2 diabetes patients failing oral antidiabetic drugs in a Swedish setting. METHODS:A published and validated computer simulation model (the CORE Diabet...

journal_title：International journal of clinical practice

authors： Goodall G,Jendle JH,Valentine WJ,Munro V,Brandt AB,Ray JA,Roze S,Foos V,Palmer AJ

更新日期：2008-06-01 00:00:00

abstract：:Graham Jackson introduced the concept that erectile dysfunction was a marker for undiagnosed cardiovascular disease and future events. Unfortunately this had had modest impact on CVD management as ED is not incorporated into current risk calculators. In this paper, we examine recent evidence as to whether ED should be...

journal_title：International journal of clinical practice

authors： Hackett G,Kirby M

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Assess and categorise the available prevalence data on coexistent LUTS and ED in the general population and among individuals consulting a healthcare provider for any reason or when seeking treatment for LUTS and/or ED. METHODS:Literature search of English-language articles published during the last 15 years...

journal_title：International journal of clinical practice

authors： Seftel AD,de la Rosette J,Birt J,Porter V,Zarotsky V,Viktrup L

更新日期：2013-01-01 00:00:00

abstract：:This trial assessed whether a simple clinical tool can be used to stratify patients with diabetes, according to risk of developing foot ulceration. This was a prospective, observational follow-up study of 3526 patients with diabetes (91% type 2 diabetes) attending for routine diabetes care. Mean age was 64.7 (range 15...

journal_title：International journal of clinical practice

authors： Leese GP,Reid F,Green V,McAlpine R,Cunningham S,Emslie-Smith AM,Morris AD,McMurray B,Connacher AC

更新日期：2006-05-01 00:00:00

abstract：:This double-blind, randomised placebo-controlled, multicentre study evaluated the efficacy, tolerability and safety of 12 weeks' treatment with controlled release darifenacin 15 mg once daily (qd), in 445 patients with overactive bladder (OAB). The primary endpoint was warning time (time from first sensation of urgenc...

journal_title：International journal of clinical practice

authors： Zinner N,Susset J,Gittelman M,Arguinzoniz M,Rekeda L,Haab F

更新日期：2006-01-01 00:00:00

abstract：:Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...

journal_title：International journal of clinical practice

authors： Rabe KF

更新日期：2003-10-01 00:00:00

abstract：:The UK National Health Service (NHS) currently spends in excess of £250 million per annum on angiotensin II receptor blockers (ARBs) for the treatment of hypertension and heart failure; with candesartan currently dominating the market. With the recent introduction of generic losartan, we set out to directly compare th...

journal_title：International journal of clinical practice

authors： Grosso AM,Bodalia PN,Macallister RJ,Hingorani AD,Moon JC,Scott MA

更新日期：2011-03-01 00:00:00

abstract：AIM:The aim of this study was to compare ezetimibe/simvastatin combination therapy with intensified statin monotherapy as alternative treatment strategies to achieve the Joint British Societies (JBS)-2 and National Institute for Health and Clinical Excellence low-density-lipoprotein cholesterol (LDL-C) target of < 2 mm...

journal_title：International journal of clinical practice

authors： McCormack T,Harvey P,Gaunt R,Allgar V,Chipperfield R,Robinson P,IN-PRACTICE study.

更新日期：2010-07-01 00:00:00

abstract：:We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. The cost per patient free from T2D was S...

journal_title：International journal of clinical practice

authors： Quilici S,Chancellor J,Maclaine G,McGuire A,Andersson D,Chiasson JL

更新日期：2005-10-01 00:00:00

abstract：:Biochemical test abnormality can indicate chronic alcohol abuse with good clinical sensitivity and specificity. Serum gamma glutamyltransferase and carbohydrate-deficient transferrin are the tests most frequently abnormal. ...

journal_title：International journal of clinical practice

authors： Rosalki SB

更新日期：1999-03-01 00:00:00

abstract：AIMS:To analyse the predictive capacity of 15 machine learning methods for estimating cardiovascular risk in a cohort and to compare them with other risk scales. METHODS:We calculated cardiovascular risk by means of 15 machine-learning methods and using the SCORE and REGICOR scales and in 38 527 patients in the Spanis...

journal_title：International journal of clinical practice

authors： Quesada JA,Lopez-Pineda A,Gil-Guillén VF,Durazo-Arvizu R,Orozco-Beltrán D,López-Domenech A,Carratalá-Munuera C

更新日期：2019-10-01 00:00:00

abstract：:Tumours of the perianal region and anal canal are uncommon and can present in a variety of ways. Acute anorectal sepsis is a common condition that usually presents as a painful lump close to the anal margin. Tumours in the perianal region may mimic the symptoms and signs of anorectal sepsis, thereby leading to a delay...

journal_title：International journal of clinical practice

authors： Bracey EE,Mathur P,Dooldeniya M,Joshi A,Dawson PM

更新日期：2003-05-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of adult blindness among individuals aged 50 and older in the Western world, with the neovascular form of AMD responsible for the most severe and rapid visual loss. Although monotherapy with currently available treatments can slow the rate of loss of vision i...

journal_title：International journal of clinical practice

authors： Kaiser PK,Do DV

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Over the last two decades the interest on patent foramen ovale (PFO) as a cause of cardioembolism in cryptogenic stroke has tremendously increased, thanks to the availability of better techniques to diagnose cardiac right-to-left shunt by ultrasounds and of percutaneous means of PFO treatment with interventi...

journal_title：International journal of clinical practice

authors： Savino K,Maiello M,Pelliccia F,Ambrosio G,Palmiero P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the Joint British Societies' (JBS 2) Factfile, cardiovascular risk assessment paper charts and electronic risk calculator posted to health professionals in general practice. DESIGN:Phase one: surveys on use of the JBS 2 charts and calculator; views on improving use and ...

journal_title：International journal of clinical practice

authors： Kirby M,Machen I

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:In late July, Cyprus experienced the second epidemic wave of COVID-19. We present the steps taken by the government and evaluate their effect on epidemic trends. MATERIALS:Cyprus Press and Information Office data were analysed. Using an R-based forecasting program, two models were created to predict cases u...

journal_title：International journal of clinical practice

authors： Kakoullis L,Eliades E,Papachristodoulou E,Parperis K,Chra P,Constantinidou A,Chatzittofis A,Sampsonas F,Panos G

更新日期：2020-12-18 00:00:00

abstract：:The aim of this study was to identify the aerobic and the anaerobic microorganisms which can be related to duct ectasia. The patients were divided into two groups. Group 1 comprised 100 patients with coloured nipple discharge (duct ectasia group), and Group 2 (the control group) was composed of 50 patients without nip...

journal_title：International journal of clinical practice

authors： Rahal RM,Júnior RF,Reis C,Pimenta FC,Netto JC,Paulinelli RR

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Although there is a general agreement for the recommendation of the influenza vaccine to persons with chronic obstructive pulmonary disease (COPD), the magnitude of clinical effectiveness and benefit from the annual vaccination is controversial. We assessed the effects of annual influenza vaccination on wint...

journal_title：International journal of clinical practice

authors： Vila-Córcoles A,Ochoa O,de Diego C,Valdivieso A,Herreros I,Bobé F,Alvarez M,Juárez M,Guinea I,Ansa X,Saún N

更新日期：2008-01-01 00:00:00

abstract：:Cases of transient global amnesia (TGA) seen by one consultant neurologist over a 4-year period (2002-2005 inclusive) were identified. Of 10 possible cases, eight fulfilled suggested diagnostic criteria. Five cases were seen as ward consultations, three in outpatient clinics; seven were seen in district general hospit...

journal_title：International journal of clinical practice

authors： Larner AJ

更新日期：2007-02-01 00:00:00

abstract：:We report a humeral fracture associated with complete radial nerve palsy, where immediate nerve recovery followed decompression. This uncommon type of nerve lesion is referred to as axonamonosis and is not included in the traditional Seddon nerve injury classification. ...

journal_title：International journal of clinical practice

authors： Marsh AJ,Singh B,Iossifidis A

更新日期：2004-01-01 00:00:00

abstract：:Urea is a major component of many daily skincare products which is widely used. Its role in the treatment of, for example atopic skin, atopic eczema, psoriasis and ichthyosis, is undisputed. However, the mode of action of urea is partly still elusive and goes far beyond its assumed passive role. This article shall elu...

journal_title：International journal of clinical practice

authors： Dirschka T

更新日期：2020-12-01 00:00:00

abstract：AIMS:This investigation determined the proportion of adults newly diagnosed as having type-2 diabetes mellitus (T2DM), and ascertained risk predictors for development of self-reported T2DM. METHODS:The US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) survey was a 5-...

journal_title：International journal of clinical practice

authors： Rodbard HW,Bays HE,Gavin JR 3rd,Green AJ,Bazata DD,Lewis SJ,Fox KM,Reed ML,Grandy S

更新日期：2012-07-01 00:00:00

abstract：:Sulphonylureas (SUs) and biguanides (metformin) are the current mainstays in the treatment of type 2 diabetes (T2DM) and represent the most commonly used oral hypoglycaemic agents (OHAs). In recent years, a variety of new OHAs have become available, including thiazolidinediones, glinides, alpha-glucosidase inhibitors,...

journal_title：International journal of clinical practice

authors： Philippe J,Raccah D

更新日期：2009-02-01 00:00:00

abstract：AIM:To develop a management strategy (rehabilitation programme) for erectile dysfunction (ED) after radiotherapy (RT) or androgen deprivation therapy (ADT) for prostate cancer that is suitable for use in a UK NHS healthcare context. METHODS:PubMed literature searches of ED management in this patient group together wit...

journal_title：International journal of clinical practice

authors： White ID,Wilson J,Aslet P,Baxter AB,Birtle A,Challacombe B,Coe J,Grover L,Payne H,Russell S,Sangar V,Van As N,Kirby M

更新日期：2015-01-01 00:00:00