Treating type 2 diabetes: how safe are current therapeutic agents?

abstract：BACKGROUND:Ageing is intrinsically associated with a progressive decline in cardiorespiratory fitness (CRF) as measured by peak oxygen uptake (VO2peak ). Improving CRF through physical activity contribute to better and healthy ageing. High-intensity interval training (HIIT) is a potent method of improving CRF among sen...

journal_title：International journal of clinical practice

authors： Bouaziz W,Malgoyre A,Schmitt E,Lang PO,Vogel T,Kanagaratnam L

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The regular use of simple analgesics in addition to opioids such as paracetamol (or acetaminophen) is recommended for persistent pain to enhance analgesia. Few studies have examined the frequency and doses of paracetamol among people with chronic non-cancer pain including use above the recommended maximum da...

journal_title：International journal of clinical practice

authors： Hoban B,Larance B,Gisev N,Nielsen S,Cohen M,Bruno R,Shand F,Lintzeris N,Hall W,Farrell M,Degenhardt L

更新日期：2015-11-01 00:00:00

abstract：:The difficulties in establishing a diagnosis of acute disseminated encephalomyelitis (ADEM) are illustrated in this case report, which attempts to raise awareness of the condition among general physicians, since they are the practitioners most likely to see such acute neurological presentations. Clinical and investiga...

journal_title：International journal of clinical practice

authors： John L,Khaleeli AA,Larner AJ

更新日期：2003-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis and steatohepatitis to cirrhosis. Based on its strongest risk factors namely visceral obesity and insulin resistance, NAFLD is thought to be the hepatic manifestation of the metabolic syndrome and is considered to be t...

journal_title：International journal of clinical practice

authors： Kaser S,Ebenbichler CF,Tilg H

更新日期：2010-06-01 00:00:00

abstract：:Ezetimibe/simvastatin (INEGY), a dual inhibitor of both cholesterol production and absorption, is a new approach to the management of hyperlipidaemia. Recent studies have shown that it produces greater reductions in low-density lipoprotein (LDL) cholesterol than the single inhibition of statin therapy, enabling many m...

journal_title：International journal of clinical practice

authors： Kastelein JJ,Sankatsing RR

更新日期：2005-12-01 00:00:00

abstract：:A press through package (PTP) is commonly used as a package for drugs and also being seen increasingly in cases of foreign body in the digestive tract. We presented three cases of inadvertent PTP ingestion with a variety of clinical presentations. Although commonly considered to be small and soft to cause bowel damage...

journal_title：International journal of clinical practice

authors： Hou SK,Chern CH,How CK,Wang LM,Huang CI,Lee CH

更新日期：2006-02-01 00:00:00

abstract：:Zearalenone (ZEN) is a non-steroidal mycoestrogen that widely contaminates agricultural products. ZEN and its derivatives share similar molecular mechanisms and activity with estrogens and interact with ERα and ERβ leading to changes in the reproductive system in both animals and humans. The reduced form of ZEN, α-ZEA...

journal_title：International journal of clinical practice

authors： Pazaiti A,Kontos M,Fentiman IS

更新日期：2012-01-01 00:00:00

abstract：:The porphyrias comprise a group of disorders of the haem biosynthesis pathway that can present with acute neurovisceral symptoms, skin lesions or both. Acute porphyrias present with severe abdominal pain, confusion and seizures which may be life-threatening. Specific treatment with haem preparations should be institut...

journal_title：International journal of clinical practice

authors： Badminton MN,Elder GH

更新日期：2002-05-01 00:00:00

abstract：AIMS:To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia. METHODS:A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treat...

journal_title：International journal of clinical practice

authors： Machado-Duque ME,Ramírez-Riveros AC,Machado-Alba JE

更新日期：2017-06-01 00:00:00

abstract：:Aortic valve disease is common and has significant impact on prognosis and quality of life. In this educational review, we cover the pathophysiology, presentation and assessment of aortic stenosis (AS) and aortic regurgitation (AR), including the role of imaging modalities beyond echocardiography. We review current tr...

journal_title：International journal of clinical practice

authors： Rayner J,Coffey S,Newton J,Prendergast BD

更新日期：2014-10-01 00:00:00

abstract：:This randomised, double-blind, placebo-controlled, parallel-group study compared the efficacy and tolerability of lumiracoxib (a novel COX-2 selective inhibitor) with rofecoxib, celecoxib and placebo in patients with moderate-to-severe post-operative dental pain. Following third molar extraction, patients received sin...

journal_title：International journal of clinical practice

authors： Kellstein D,Ott D,Jayawardene S,Fricke J

更新日期：2004-03-01 00:00:00

abstract：:Gastrointestinal tract (GIT) foreign bodies represent a significant clinical problem in the Emergency Department, causing a high degree of financial burden, morbidity and mortality. A large variety of foreign bodies are accidentally ingested or inserted into the GIT in different age groups. This a retrospective review...

journal_title：International journal of clinical practice

authors： Ayantunde AA,Oke T

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Alternatives to acute hospital admission are required to accommodate the increasing pressures on health services. Since physiotherapists and occupational therapists are integral to inpatient teams, they may also be integral to admission replacement services, and thus their roles in these services merit inves...

journal_title：International journal of clinical practice

authors： Harris C,Ignatowicz A,Lasserson DS

更新日期：2020-06-01 00:00:00

abstract：:The objective of this study was to investigate the impact of rivastigmine therapy on attention, apathy, anxiety and agitation in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting. Patients with mild-to-moderate AD were enrolled in the study by physicians across Canada. They were ...

journal_title：International journal of clinical practice

authors： Gauthier S,Juby A,Rehel B,Schecter R

更新日期：2007-06-01 00:00:00

abstract：AIMS:The main objective of this study was to see whether diabetes is associated with an increased collision risk and to test the effect of age and gender on the overall collision risk for diabetes drivers. MATERIALS AND METHODS:Twenty-eight studies were included in meta-analysis, using mean age, gender, continent and ...

journal_title：International journal of clinical practice

authors： Hostiuc S,Negoi I,Hostiuc M

更新日期：2016-07-01 00:00:00

abstract：:To evaluate the results of post-operative chemoirradiation for gastric carcinoma. The records of 58 patients who underwent resection for gastric carcinoma were retrospectively reviewed. Forty-six patients had complete resection without any residual disease but with high-risk factors of relapse. Twelve patients had mic...

journal_title：International journal of clinical practice

authors： Bora H,Unsal D,Akmansu M

更新日期：2004-05-01 00:00:00

abstract：:We report a case of acute myocardial infarction in an HIV-infected patient without significant coronary artery disease (CAD) risk factors. The patient underwent rescue percutaneous transluminal coronary angioplasty (PTCA), with a successful outcome. We presume a possible pathogenetic role of anti-retroviral therapy an...

journal_title：International journal of clinical practice

authors： Saporito F,Micari A,Raffa S,Cerrito M,Micari G,Grassi R

更新日期：2005-03-01 00:00:00

abstract：:Despite efforts to diagnose and treat hypertension effectively, the goal of lowering blood pressure (BP) levels is rarely achieved, as treatment is often initiated with a single antihypertensive agent. The aim of this study was to assess the safety and efficacy of a first-line fixed-dose combination treatment compared...

journal_title：International journal of clinical practice

authors： Scholze J,Bida M,Hansen A,Juncken D,Rangoonwala B,Ritz A,Schnitker J,Dörffel Y

更新日期：2006-03-01 00:00:00

abstract：:Erectile dysfunction (ED) shares the same risk factors as coronary artery disease, so the level of occult cardiovascular risk in men with ED was assessed. A total of 174 men presenting with ED underwent cardiac risk stratification according to the Princeton Consensus Guidelines. Thirty per cent were stratified as inte...

journal_title：International journal of clinical practice

authors： Solomon H,Man J,Wierzbicki AS,O'Brien T,Jackson G

更新日期：2003-03-01 00:00:00

abstract：:Urea is a major component of many daily skincare products which is widely used. Its role in the treatment of, for example atopic skin, atopic eczema, psoriasis and ichthyosis, is undisputed. However, the mode of action of urea is partly still elusive and goes far beyond its assumed passive role. This article shall elu...

journal_title：International journal of clinical practice

authors： Dirschka T

更新日期：2020-12-01 00:00:00

abstract：:Thyroid cancer is uncommon with an estimated lifetime risk of 0.8% for women and 0.3% for men. The incidence appears to be increasing by 4% per year and is currently the eighth commonest cancer in women. Managing thyroid cancer is challenging, as no prospective randomised trials exist. Most of the information is deriv...

journal_title：International journal of clinical practice

authors： Nix P,Nicolaides A,Coatesworth AP

更新日期：2005-11-01 00:00:00

abstract：AIMS:Intervention studies have shown that angiotensin receptor blockers (ARB) may reduce the incidence of type 2 diabetes mellitus. It is currently unclear whether short-term therapy with ARBs affects metabolic parameters. METHODS:i-RESPOND, a randomised, controlled, multicentre, double-blind study evaluated the effec...

journal_title：International journal of clinical practice

authors： Parhofer KG,Birkeland KI,DeFronzo R,Del Prato S,Bhaumik A,Ptaszynska A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Lozenges containing Amylmetacresol and 2,4-Dichlorobenzylalcohol (AMC/DCBA, eg Strepsils® ) are marketed as a remedy for acute sore throat. This over-the-counter formulation has antiseptic and local anaesthetic qualities. OBJECTIVES:The objective of this systematic review and meta-analysis is to evaluate th...

journal_title：International journal of clinical practice

authors： Weckmann G,Hauptmann-Voß A,Baumeister SE,Klötzer C,Chenot JF

更新日期：2017-10-01 00:00:00

abstract：AIMS:Although many elderly individuals suffer from type 2 diabetes, the effectiveness of cardioprotective drugs in primary prevention of cardiovascular events in clinical practice in this population has rarely been evaluated. We aimed to assess the effectiveness of, (i) angiotensin converting enzyme inhibitors or angio...

journal_title：International journal of clinical practice

authors： Sirois C,Moisan J,Poirier P,Grégoire JP

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:The influence of cardiovascular risk factors/comorbidities on response to oral once-daily tadalafil 5 mg was explored in men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). METHODS:This post hoc analysis pooled data from four double-blind studies in which 1498 men wit...

journal_title：International journal of clinical practice

authors： Vlachopoulos C,Oelke M,Maggi M,Mulhall JP,Rosenberg MT,Brock GB,Esler A,Büttner H

更新日期：2015-12-01 00:00:00

abstract：AIMS:We aimed to compare the effect of risedronate (RIS) and teriparatide (TPTD) (recombinant human parathyroid hormone 1-34) on bone turnover markers in women with postmenopausal osteoporosis. METHODS:Forty-four Caucasian women (age 65.1 +/- 1.6 years) with postmenopausal osteoporosis were randomly assigned to receiv...

journal_title：International journal of clinical practice

authors： Anastasilakis AD,Goulis DG,Polyzos SA,Gerou S,Koukoulis GN,Efstathiadou Z,Kita M,Avramidis A

更新日期：2008-06-01 00:00:00

abstract：:The aim of this study was to audit the preoperative administration of regular cardiac medication in general surgical patients and to determine if this can be improved with simple ward-based education. The notes and drug charts of 102 general surgical adult inpatients undergoing elective operations were analysed prospe...

journal_title：International journal of clinical practice

authors： Corfield LF,Trivedi PM,Wilson D

更新日期：2006-10-01 00:00:00

abstract：:Fluid in the pleural space is a common sequela of a wide range of diseases which may be pulmonary, pleural or extrapulmonary. As the differential diagnosis is wide, a systematic approach to investigation and diagnosis is recommended. This review highlights the important features and recommendations for the investigati...

journal_title：International journal of clinical practice

authors： McGrath EE,Blades Z,Needham J,Anderson PB

更新日期：2009-11-01 00:00:00

abstract：:Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...

journal_title：International journal of clinical practice

authors： Rabe KF

更新日期：2003-10-01 00:00:00

abstract：:The aim of this study was to assess the interventions by general practitioners on cardiovascular risk factors among persons without a history of cardiovascular disease attending for a cardiovascular check-up. All inhabitants of three Belgian towns aged between 45 and 64 years were invited for a cardiovascular check-up...

journal_title：International journal of clinical practice

authors： Devroey D,Kartounian J,Vandevoorde J,Betz W,Cogge M,De Man B,De Ridder L,Block P,Van Gaal L

更新日期：2004-02-01 00:00:00