Abstract：
:This randomised, double-blind, placebo-controlled, parallel-group study compared the efficacy and tolerability of lumiracoxib (a novel COX-2 selective inhibitor) with rofecoxib, celecoxib and placebo in patients with moderate-to-severe post-operative dental pain. Following third molar extraction, patients received single oral doses of lumiracoxib 400 mg, rofecoxib 50 mg, celecoxib 200 mg or placebo (n = 355). Additional patients from a similar study, assigned to lumiracoxib, rofecoxib or placebo (n = 155), were included for analysis of the primary variable, Summed Pain Intensity Difference over the first 8 h post dose (SPID-8). For SPID-8, lumiracoxib was superior to rofecoxib (p < 0.05), celecoxib (p < 0.001) and placebo (p < 0.001). Lumiracoxib demonstrated the fastest onset of analgesia and the longest time to rescue medication use. Patient global evaluation of lumiracoxib was comparable to rofecoxib and superior to celecoxib and placebo. All treatments were well tolerated. Lumiracoxib 400 mg provides rapid, effective and sustained relief of post-operative dental pain, comparable or superior to rofecoxib.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Kellstein D,Ott D,Jayawardene S,Fricke Jdoi
10.1111/j.1368-5031.2004.00155.xsubject
Has Abstractpub_date
2004-03-01 00:00:00pages
244-50issue
3eissn
1368-5031issn
1742-1241journal_volume
58pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Studies in the primary care setting are of high interest for assessing the management situation of patients with manifestations of atherothrombosis. AIMS:Therefore, we documented diagnostic procedures, characteristics, and management of patients with symptomatic and asymptomatic peripheral arterial disease ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2010.02337.x
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:'Do Not Attempt Cardiopulmonary Resuscitation' (DNACPR) orders are made frequently for older people in hospital. Sensitive anticipatory discussion is encouraged where possible, but usually this does not happen, despite the evidence suggesting that many older patients would like to be involved in such decisio...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12067
更新日期：2013-04-01 00:00:00
abstract：:A case is presented of a patient who described a koro-like syndrome related to amfetamine use; this consisted of a perception that his penis had reduced in size and was at risk of being sucked into his body. He described this as Whizz-Dick. This condition was also reported independently by amfetamine users attending a...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2004.00035.x
更新日期：2004-07-01 00:00:00
abstract：:Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them 'indefini...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2012.02921.x
更新日期：2012-06-01 00:00:00
abstract：AIMS:The aim of this study was to describe and compare treatment modifications and discontinuation, adherence levels and response to treatment in patients with type 2 diabetes initiating on low-dose vs. standard-dose statin treatment. METHODS:A 2-year follow-up cohort study was performed using data from the Groningen ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12806
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION AND PURPOSE:The need for aggressive efforts to help tobacco users quit remains a healthcare priority. Brief interventions delivered in the healthcare environment continue to be a valuable component of a comprehensive tobacco control policy. Unfortunately, such treatments are offered less often than desired...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12386
更新日期：2014-07-01 00:00:00
abstract：:The role of clinician educators (CEs) in institutions and medical centres continues to be vital without any doubt. Although there has been more than a century since Sir William Osler established the role of the CE and the tradition by encouraging bed-side teaching, there is still a lack of consensus on the attributes ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2011.02780.x
更新日期：2011-11-01 00:00:00
abstract：AIM:To assess attitudes and beliefs towards benign prostatic hyperplasia (BPH)/ lower urinary tract symptoms (LUTS) and its treatment among patients and physicians in Latin America, Asia Pacific and the Commonwealth of Independent States (CIS). METHODS:Cross-sectional, quantitative study conducted between December 201...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.12879
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:The impact of hip fracture because of a fall on health-related quality of life (HRQoL) and activities of daily living (ADL) have not been well established. AIM:To evaluate changes in HRQoL and the ability to conduct ADL among patients with hip fracture because of a fall and to compare these changes with pat...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12527
更新日期：2015-04-01 00:00:00
abstract：AIM:Real-world data on treatment patterns/outcomes in patients with advanced melanoma, while scarce, are useful for health technology assessments that govern patient access in many countries. We collected retrospective data on treatment patterns among patients in France, Germany and the UK with Stage IIIB/IIIC melanoma...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12946
更新日期：2017-05-01 00:00:00
abstract：:The objectives of this survey were to establish the prevalence, onset, severity and impact of incontinence and attitudes towards the availability of advice and treatment in female adults with cystic fibrosis (CF) in Northern Ireland. All female patients (n=59) at the Northern Ireland Regional Adult CF Centre were post...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：:A 62-year-old man presented with a five-day history of a 'flu-like' illness, epigastric pain and a state of increasing confusion. His serum values for amylase and glucose were grossly elevated, as was the creatine kinase (CK) activity, being 23 times above the upper limit of normal. CK-MB was less than 5% of his total...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Zearalenone (ZEN) is a non-steroidal mycoestrogen that widely contaminates agricultural products. ZEN and its derivatives share similar molecular mechanisms and activity with estrogens and interact with ERα and ERβ leading to changes in the reproductive system in both animals and humans. The reduced form of ZEN, α-ZEA...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2011.02805.x
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:This study evaluated individuals' language preferences for discussing obesity and binge eating. METHOD:Participants (N = 817; 68.3% female) were an online community sample. They rated the desirability of terms related to obesity and binge eating, and also completed psychometrically established eating-disorde...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12835
更新日期：2016-08-01 00:00:00
abstract：:Omalizumab, a recombinant, humanised monoclonal antibody against human IgE, will be introduced soon for the treatment of allergic asthma. This antibody binds circulating IgE molecules and inhibits the type I immune response in the lung and other target organs. In the phase II and III studies performed, it demonstrated...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:The porphyrias comprise a group of disorders of the haem biosynthesis pathway that can present with acute neurovisceral symptoms, skin lesions or both. Acute porphyrias present with severe abdominal pain, confusion and seizures which may be life-threatening. Specific treatment with haem preparations should be institut...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
abstract：AIMS:Little is known on factors associated with switching and combination use of antidepressants. Our aim was to describe such use and to analyse the association with socioeconomic factors and level of care in Swedish adults aged 20-34 years. METHODS:Individuals, aged 20-34 years, who purchased an antidepressant in Ja...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12263
更新日期：2013-12-01 00:00:00
abstract：:Serum prostate-specific antigen (PSA) measurement is used to investigate patients with lower urinary tract symptoms and to screen for prostatic malignancy in symptom-free males over 50 years of age. Approximately 60% of patients with early (prostate-confined) occult malignancy show increased serum PSA levels, as do so...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:TT virus (TTV) is a novel DNA virus that has been identified in patients with post-transfusional hepatitis of unknown aetiology. However, its pathogenic role in liver injury remains unclear. To determine its frequency and clinical impact in cryptogenic liver diseases, we investigated the TTV prevalence in patients wit...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：AIMS:Stress hyperglycaemia during hospitalisation may be the first sign of diabetes mellitus (DM). Most hospitals routinely measure blood glucose, which may enable early diagnosis. This study measured the prevalence of hyperglycaemia in hospitalised adults with no history of diabetes, and whether the discharge summary ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12690
更新日期：2015-11-01 00:00:00
abstract：:Twin reversed arterial perfusion (TRAP) syndrome is an extremely rare manifestation of feto-fetal transfusion syndrome. This condition is seen in monozygotic twin pregnancies, where the affected twin is perfused retrogradely by the healthy twin. The affected twin presents with bizarre malformations such as acardia and...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:The use of hormone replacement therapy (HRT) for cardiovascular risk reduction remains uncertain. Although previous epidemiological surveys have suggested a clear benefit and nearly 50% mortality risk reduction with HRT in postmenopausal women, recent randomised trials have largely failed to support this. The epidemio...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：AIMS:Studies on macrovascular consequences of glucose control in elderly patients (>75 years) with type 2 diabetes mellitus (T2DM) are lacking. The present study aimed to investigate the relationship between HbA(1c) and mortality in this specific population. METHODS:Between 1998 and 1999, 374 primary care patients wit...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2010.02596.x
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Limited research has examined the fat-but-fit paradigm among coronary artery disease patients. OBJECTIVES:The objective of this study was to evaluate the fat-but-fit paradigm as it relates to mortality risk among patients with coronary artery disease. METHODS:A total of 766 coronary artery disease patients...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12799
更新日期：2016-05-01 00:00:00
abstract：:Tuberculosis is an uncommon cause of carpal tunnel syndrome. We report a patient with systemic lupus erythematosus who developed hand numbness. Ultrasonic, operative and microbiological findings supported the diagnosis of median nerve compression secondary to a tuberculous abscess. The symptoms resolved with surgical ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:We report a case of acute myocardial infarction in an HIV-infected patient without significant coronary artery disease (CAD) risk factors. The patient underwent rescue percutaneous transluminal coronary angioplasty (PTCA), with a successful outcome. We presume a possible pathogenetic role of anti-retroviral therapy an...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2004.00246.x
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate the use of computed tomography (CT) as the first imaging modality in patients with renal colic and microscopic haematuria. METHODOLOGY:The patients that presented to the emergency service of six health centers with renal colic between January 2017 and January 2018 and were found to have ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13826
更新日期：2020-11-09 00:00:00
abstract：:The management approach to non-insulin-dependent diabetes mellitus among family doctors in Hong Kong was studied using two case histories. In 1996, all 804 fellows, members and associate members of the Hong Kong College of Family Physicians were sent a letter and a questionnaire. Of the 512 who responded, 405 were mal...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Acute pulmonary oedema can sometimes complicate adenotonsillectomy carried out for obstructive sleep apnoea. Early recognition and adequate oxygenation are the key to management. We report such a case; the pathophysiology and management of this rare complication of a common procedure are discussed. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：AIMS:This investigation determined the proportion of adults newly diagnosed as having type-2 diabetes mellitus (T2DM), and ascertained risk predictors for development of self-reported T2DM. METHODS:The US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) survey was a 5-...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2012.02952.x
更新日期：2012-07-01 00:00:00
