Prescribing patterns, adherence and LDL-cholesterol response of type 2 diabetes patients initiating statin on low-dose versus standard-dose treatment: a descriptive study.

Abstract:

AIMS:The aim of this study was to describe and compare treatment modifications and discontinuation, adherence levels and response to treatment in patients with type 2 diabetes initiating on low-dose vs. standard-dose statin treatment. METHODS:A 2-year follow-up cohort study was performed using data from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database in patients with type 2 diabetes initiating statin treatment between January 2007 and December 2012. First, we determined whether there were differences in treatment modifications and discontinuation after statin initiation between patients starting on a low-dose vs. standard-dose. Second, we looked at differences in adherence and LDL-cholesterol response after 2 years follow-up between these groups. RESULTS:Around 22% of patients initiated statin treatment on a dose lower than recommended. More than half of them remained on a low dose during a 2-year follow-up period, whereas less than 15% received a dose increase. Of the patients initiating on standard-dose, also more than half remained on the same treatment during this period, whereas 8% received a dose decrease without subsequent increase. Over 25% of patients starting on low-dose or standard-dose treatment discontinued treatment, often within the first 180 days after initiation or after a first treatment change. Patients on low-dose treatment had lower adherence levels and were less likely to have adequate LDL-cholesterol response compared with patients on standard-dose after 2 years follow-up. CONCLUSIONS:Current patterns of statin treatment in patients with type 2 diabetes are suboptimal, with discontinuation, inadequate adherence levels and lack of treatment intensification seen in those who had inadequate LDL-cholesterol response after 2 years of follow-up. Patients starting on low-dose had more treatment modifications, discontinuation and adherence problems as compared with those starting on standard-dose treatment, which calls for a closer look at the rationale of starting patients on low-dose statin treatment.

journal_name

Int J Clin Pract

authors

de Vries FM,Voorham J,Hak E,Denig P

doi

10.1111/ijcp.12806

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

482-92

issue

6

eissn

1368-5031

issn

1742-1241

journal_volume

70

pub_type

杂志文章
  • Does malnutrition in clubfoot patients affect Ponseti technique and its outcome?

    abstract:OBJECTIVES:Malnutrition is a crucial health problem predominantly in the developing countries. Malnutrition in children is one of the main risk factors for diseases and mortality. Club foot or congenital talipes equinovarus (CTEV) is the most common form of congenital orthopaedic abnormality. Over the past 20 years, th...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.13957

    authors: Muzzammil M,Mughal A,Qadir A,Mughal A,Effendi J,Bhatti A,Minhas MS

    更新日期:2020-12-20 00:00:00

  • Coexisting lower urinary tract symptoms and erectile dysfunction: a systematic review of epidemiological data.

    abstract:OBJECTIVE:Assess and categorise the available prevalence data on coexistent LUTS and ED in the general population and among individuals consulting a healthcare provider for any reason or when seeking treatment for LUTS and/or ED. METHODS:Literature search of English-language articles published during the last 15 years...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/ijcp.12044

    authors: Seftel AD,de la Rosette J,Birt J,Porter V,Zarotsky V,Viktrup L

    更新日期:2013-01-01 00:00:00

  • Mistaken first impressions: a response.

    abstract::In this journal, Cummins et al reported an experiment that examined clinicians' predictions of causes of death from subjects' pre-morbid photographs. They found that clinicians performed at chance. The validity of two of their other conclusions are challenged. First, that clinicians routinely form impressions of how a...

    journal_title:International journal of clinical practice

    pub_type: 评论,杂志文章

    doi:

    authors: Lewis MB,Ellis HD

    更新日期:2000-03-01 00:00:00

  • Patent foramen ovale and cryptogenic stroke: from studies to clinical practice: Position paper of the Italian Chapter, International Society Cardiovascular Ultrasound.

    abstract:BACKGROUND:Over the last two decades the interest on patent foramen ovale (PFO) as a cause of cardioembolism in cryptogenic stroke has tremendously increased, thanks to the availability of better techniques to diagnose cardiac right-to-left shunt by ultrasounds and of percutaneous means of PFO treatment with interventi...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/ijcp.12842

    authors: Savino K,Maiello M,Pelliccia F,Ambrosio G,Palmiero P

    更新日期:2016-08-01 00:00:00

  • Angiotensin II receptor blocker prevents upper gastrointestinal bleeding in hypertensive patients with chronic kidney disease not on dialysis.

    abstract:AIMS:Investigate if angiotensin II receptor blocker (ARB) decreases risk of upper gastrointestinal bleeding (UGIB) in hypertensive patients with chronic kidney disease (CKD) not on dialysis. METHODS:All hypertensive patients with CKD not on dialysis in outpatient department of China Medical University Hospital from 20...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.12589

    authors: Chou CY,Wang SM,Chang PH,Kuo HL,Chang CT,Liu JH,Wang IK,Yang YF,Liang CC,Huang CC

    更新日期:2015-07-01 00:00:00

  • A comparison of valsartan and captopril in patients with essential hypertension in Indonesia.

    abstract::Adult Indonesian outpatients were randomised to receive either valsartan 80 mg once daily or captopril 25 mg twice daily for 8 weeks. The main criterion for tolerability was the incidence of adverse events. The primary efficacy variable was the change in mean sitting diastolic blood pressure (SDBP) from baseline to en...

    journal_title:International journal of clinical practice

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Prabowo P,Arwanto A,Soemantri D,Sukandar E,Suprihadi H,Parsudi I,Markum MS,Kabo P,Atmoko R,Prodjosudjadi W

    更新日期:1999-06-01 00:00:00

  • The transition from medical student to doctor: perceptions of final year students and preregistration house officers related to expected learning outcomes.

    abstract::In this prospective qualitative study over 12 months, we evaluated the educational and clinical effectiveness of a new final year undergraduate programme in a London medical school (Guy's, King's and St Thomas'). A stratified sample of 17/360 final year students were interviewed four times, and the content was assesse...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/j.1742-1241.2005.00438.x

    authors: Lempp H,Seabrook M,Cochrane M,Rees J

    更新日期:2005-03-01 00:00:00

  • Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions.

    abstract::This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via medline and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1742-1241.2005.00685.x

    authors: Karcioglu O,Arnold J,Topacoglu H,Ozucelik DN,Kiran S,Sonmez N

    更新日期:2006-12-01 00:00:00

  • Evaluation of balance in patients with chronic obstructive pulmonary disease with practical tests.

    abstract:INTRODUCTION:Patients with chronic obstructive pulmonary disease (COPD) have impaired balance and hence fall more frequently. Easy application of balance evaluation tests can prevent the loss of time in the outpatient clinic for patients with COPD. In this study, we aimed to compare the efficacy of Berg Balance Scale (...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.13901

    authors: Yazici O,Ceylan E,Demir Yazici S,Tas Gulen S

    更新日期:2020-12-07 00:00:00

  • Cefaclor af versus amoxycillin/clavulanate in acute bacterial exacerbations of chronic bronchitis: a randomised multicentre study.

    abstract::Cefaclor and amoxycillin/clavulanate are active against Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Staphylococcus aureus--pathogens commonly associated with acute exacerbations of chronic bronchitis (AECB). This randomised, parallel-group, single-blind, multicentre study investigated t...

    journal_title:International journal of clinical practice

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Bandak SI,Bolzon LD,Turnak MR,Johns D,Henle SK,Allen BS

    更新日期:1999-12-01 00:00:00

  • Autologous tissue immediate breast reconstruction: desired but oncologically safe?

    abstract:BACKGROUND:There has been a dramatic increase in the incidence of immediate breast reconstruction after mastectomy for breast cancer over the past few decades and autologous tissue flaps are being used with increasing frequency. Concern has been expressed that these complex procedures may lead to a delay in the deliver...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-1241.2009.02199.x

    authors: Lewis RS,Kontos M

    更新日期:2009-11-01 00:00:00

  • Inhaled corticosteroids and the increased risk of pulmonary tuberculosis: a population-based case-control study.

    abstract:AIMS:The association between inhaled corticosteroid (ICS) use and pulmonary tuberculosis (TB) development is uncertain. We conducted a population-based case-control study to investigate whether ICS use increases the risk of developing TB. METHODS:Tuberculosis patients aged 18 years and older were identified using the ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.12459

    authors: Chung WS,Chen YF,Hsu JC,Yang WT,Chen SC,Chiang JY

    更新日期:2014-10-01 00:00:00

  • Effectiveness and safety of outpatient parenteral antimicrobial therapy in acute exacerbation of chronic obstructive pulmonary disease.

    abstract:AIM:We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS:Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ijcp.13022

    authors: Ponce González MA,Mirón Rubio M,Mujal Martinez A,Estrada Cuxart O,Fiuza Perez D,Salas Reinoso L,Fernández Fabrellas E,Chiner Vives E

    更新日期:2017-12-01 00:00:00

  • An analysis of an open access general practitioner bone densitometry service.

    abstract::General practitioners (GPs) are increasingly involved in the selective opportunistic case finding of osteoporosis and treatment of this condition. An open access bone densitometry service has existed for GPs in the Cardiff area since 1993. The purpose of this study was to assess the effectiveness of this service, part...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/j.1368-5031.2004.00151.x

    authors: Sim MF,Stone M,Johansen A,Ho P,Pettit RJ,Evans WD

    更新日期:2004-03-01 00:00:00

  • State of the art in beta2-agonist therapy: a safety review of long-acting agents.

    abstract::Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:

    authors: Rabe KF

    更新日期:2003-10-01 00:00:00

  • Acute renal infarction: a 10-year experience.

    abstract::The diagnosis of acute renal infarction (ARI) is often delayed or unrecognised because of its non-specific presentation and the rarity of the disease. We evaluated the clinical presentations, laboratory findings, underlying medical conditions and treatment of 18 Chinese patients with ARI who presented to the emergency...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/j.1742-1241.2006.01136.x

    authors: Tsai SH,Chu SJ,Chen SJ,Fan YM,Chang WC,Wu CP,Hsu CW

    更新日期:2007-01-01 00:00:00

  • Utilisation of self-care products and practices and its associated factors among stroke survivors.

    abstract::This study explored the characteristics associated with the use of self-care products and practices by people rehabilitating from stroke. A cross-sectional sub-study of the Sax Institute's 45 and Up Study in which 1300 participants who had indicated a doctor had diagnosed them as having had a stroke were mailed a sub-...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.13821

    authors: Sibbritt D,Steel A,Peng W,Adams J

    更新日期:2020-11-07 00:00:00

  • Comparison of the once-daily levofloxacin-containing triple therapy with the twice-daily standard triple therapy for first-line Helicobacter pylori eradication: a prospective randomised study.

    abstract:BACKGROUND/AIMS:Simple compound of Helicobacter pylori eradication therapy may improve drug compliance of patients. The aims of this study were to compare the efficacy and tolerability of a simple combination containing levofloxacin 7-day once-daily with standard twice-daily triple therapy. PATIENTS AND METHODS:This w...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1742-1241.2010.02482.x

    authors: Chen LW,Chien RN,Chang JJ,Fang KM,Chang LC

    更新日期:2010-10-01 00:00:00

  • The Effect of Body Mass Index on Oncological and Surgical Outcomes in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Multicenter Study of the Association of Urooncology, Turkey.

    abstract:OBJECTIVE:We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). MATERIALS AND METHODS:We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.13750

    authors: Izol V,Deger M,Baltaci S,Akgul M,Selvi İ,Ozden E,Süer E,Zuhtu Tansug M,Bladder Cancer Study Group of Association of Urooncology, Turkey.

    更新日期:2020-10-08 00:00:00

  • Erectile dysfunction and lower urinary tract symptoms: a consensus on the importance of co-diagnosis.

    abstract::Despite differences in design, many large epidemiological studies using well-powered multivariate analyses consistently provide overwhelming evidence of a link between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS). Preclinical evidence suggests that several common pathophysiological mechanisms are ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.12176

    authors: Kirby M,Chapple C,Jackson G,Eardley I,Edwards D,Hackett G,Ralph D,Rees J,Speakman M,Spinks J,Wylie K

    更新日期:2013-07-01 00:00:00

  • Massive upper gastrointestinal haemorrhage due to intragastric rupture of a splenic artery aneurysm.

    abstract::Most cases of splenic artery aneurysm are asymptomatic, being found incidentally at the time of investigations (e.g. ultrasound, computed tomography, angiography) or laparotomy for other conditions. Rupture of a splenic artery aneurysm with erosion into the stomach is a rare cause of massive upper gastrointestinal hae...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:

    authors: Moawad M,Ray S,Joseph JV

    更新日期:2002-07-01 00:00:00

  • Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis and steatohepatitis to cirrhosis. Based on its strongest risk factors namely visceral obesity and insulin resistance, NAFLD is thought to be the hepatic manifestation of the metabolic syndrome and is considered to be t...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-1241.2009.02327.x

    authors: Kaser S,Ebenbichler CF,Tilg H

    更新日期:2010-06-01 00:00:00

  • Headache in essential thrombocythaemia.

    abstract::Headache is frequently reported as one of the neurological manifestations of essential thrombocythaemia (ET) and other myeloproliferative neoplasms. It is associated with considerable morbidity; yet, it is a frequently under-recognised symptom. In patients with ET, headaches may be attributable to the disease, to the ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/j.1742-1241.2012.02986.x

    authors: Frewin R,Dowson A

    更新日期:2012-10-01 00:00:00

  • TVT-O vs TVT-S for female stress urinary incontinence: A systematic review and meta-analysis.

    abstract:BACKGROUND:Tension-free vaginal tape obturator (TVT-O) and tension-free vaginal tape secur (TVT-S) are common surgeries for the treatment of stress urinary incontinence (SUI), several randomised controlled trials (RCTs) have compared the effects of TVT-O and TVT-S, yet the results remained inconsistent. Therefore, we a...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,meta分析

    doi:10.1111/ijcp.13506

    authors: Song B,He Y,Shen R,Shao H,He X,Wang X,Sheng T,Zhu X,Jiang D

    更新日期:2020-09-01 00:00:00

  • Chronic renal failure in a patient with Sotos syndrome due to autosomal dominant polycystic kidney disease.

    abstract::Sotos syndrome is characterised by accelerated growth, acromegalic appearance, mental retardation and social maladjustment. Most cases are sporadic, but familial cases have also been reported. We report a case of Sotos syndrome presenting with chronic renal failure due to autosomal dominant polycystic kidney disease (...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:

    authors: Cefle K,Yildiz A,Palanduz S,Ozturk S,Ozbey N,Kylyçaslan I,Colakoglu S,Balci C

    更新日期:2002-05-01 00:00:00

  • Comparison of spiramycin and clarithromycin for community-acquired lower respiratory tract infections.

    abstract::This open multicentre study compared the efficacy and tolerability of clarithromycin and spiramycin in the treatment of lower respiratory tract infections in Brazil and Colombia. A total of 125 patients with a clinical and radiological diagnosis of pneumonia, acute bronchitis or exacerbation of chronic bronchitis were...

    journal_title:International journal of clinical practice

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Rocha RT,Awad CE,Ali A,Matyas R,Vital AC,Silva CO,Dainesi SM,Salazar MS,Nakatani J

    更新日期:1999-09-01 00:00:00

  • Is paediatric day case tonsillectomy desirable? The parents' perspective.

    abstract::Tonsillectomy is the most commonly performed otolaryngological procedure in most units. There is considerable financial pressure to perform paediatric tonsillectomy as a day case. Responding to concern that day case tonsillectomy might not be welcomed by parents or felt to be in the best interests of the patients, we ...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:

    authors: Vowles R,Loney E,Williams H,Gormley-Fleming E,Kulkarni P,Ryan R

    更新日期:2000-05-01 00:00:00

  • Management of the elderly patient with advanced non-small cell lung cancer.

    abstract::Non-small cell lung cancer (NSCLC) is the most lethal of the common solid malignancies. It is predominantly a disease of the elderly with the median age at diagnosis 68 years. Unfortunately, the majority of patients present with advanced disease whereby palliation is the primary aim of treatment. The elderly have a lo...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章,评审

    doi:10.1111/j.1368-5031.2005.00795.x

    authors: Cheong KA,Chrystal K,Harper PG

    更新日期:2006-03-01 00:00:00

  • The effect of splenectomy on the levels of PCV-13-induced memory B- and T cells.

    abstract:AIM:Splenectomised patients are associated with lifelong risk of fatal overwhelming post-splenectomy infection (OPSI), which is mostly caused by Streptococcus pneumoniae. Today OPSI cases can still be reported even in patients with appropriate vaccination. In our study, the levels of vaccine-specific memory B- and T ce...

    journal_title:International journal of clinical practice

    pub_type: 杂志文章

    doi:10.1111/ijcp.13077

    authors: Gazi U,Karasartova D,Sahiner IT,Gureser AS,Tosun O,Derici MK,Dolapci M,Taylan Ozkan A

    更新日期:2018-05-01 00:00:00

  • Anti-venom-induced myelopathy in a semipoisonous snakebite.

    abstract::A 40-year-old woman developed myelopathy manifesting as Brown Sequard syndrome after administration of Anti-venom (polyvalent enzyme-refined equine globulin supposed to neutralise 0.6 mg of standard cobra venom, 0.45 mg of standard krait venom, 0.6 mg of standard Russel's viper venom and 0.45 mg of saw scaled viper ve...

    journal_title:International journal of clinical practice

    pub_type: 信件

    doi:10.1111/j.1368-5031.2004.00201.x

    authors: Biswas R,Irodi A,Paul A,Ghimere G,Joshi KR,Alurkar VM,Shetty KJ

    更新日期:2004-06-01 00:00:00