Abstract:
:Non-small cell lung cancer (NSCLC) is the most lethal of the common solid malignancies. It is predominantly a disease of the elderly with the median age at diagnosis 68 years. Unfortunately, the majority of patients present with advanced disease whereby palliation is the primary aim of treatment. The elderly have a long history of undertreatment and non-inclusion in clinical trials with regard to cancer. Elderly-specific studies demonstrate that chemotherapy provides both a survival and quality-of-life benefit in advanced NSCLC. Increasing emphasis is placed on the objective assessment of fitness for chemotherapy and the integration of molecularly targeted agents into treatment paradigms.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Cheong KA,Chrystal K,Harper PGdoi
10.1111/j.1368-5031.2005.00795.xsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
340-3issue
3eissn
1368-5031issn
1742-1241pii
IJCP795journal_volume
60pub_type
杂志文章,评审abstract::Cerebellitis is not a recognised manifestation of Lyme disease. We describe a patient with clinical features of subacute cerebellitis, cerebrospinal fluid (CSF) monocytic pleocytosis, positive CSF Borrelia burgdorferi antibodies, negative brain magnetic resonance imaging and a benign course after treatment with ceftri...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:We recently described early rigid retrograde endoscopic realignment of the disrupted urethra under caudal anaesthesia in the outpatient setting. This retrospective study was performed to evaluate our medium-term results. PATIENTS AND METHODS:A retrospective review of patients who had early rigid retrograde e...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01481.x
更新日期:2010-01-01 00:00:00
abstract::Sexual activity is no more stressful to the heart when compared with a number of other natural daily activities, e.g. walking one mile on the level in 20 minutes. The cardiac risk of sexual activity in patients diagnosed with cardiovascular disease is minimal in properly assessed and advised patients. Erectile dysfunc...
journal_title:International journal of clinical practice
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
abstract::Hypogonadism may play a significant role in the pathophysiology of erectile dysfunction (ED). A threshold level of testosterone may be necessary for normal erectile function. Testosterone replacement therapy is indicated in hypogonadal patients and is beneficial in patients with ED and hypogonadism. Monotherapy with t...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2006.01101.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Emerging research demonstrates an interrelationship between systemic inflammation, physical activity and premature all-cause mortality among chronic obstructive pulmonary disease (COPD) patients. Less common in this literature is the use of objective measures of physical activity and representative samples o...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12778
更新日期:2016-03-01 00:00:00
abstract:INTRODUCTION AND PURPOSE:The need for aggressive efforts to help tobacco users quit remains a healthcare priority. Brief interventions delivered in the healthcare environment continue to be a valuable component of a comprehensive tobacco control policy. Unfortunately, such treatments are offered less often than desired...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12386
更新日期:2014-07-01 00:00:00
abstract:AIMS:Little is known on factors associated with switching and combination use of antidepressants. Our aim was to describe such use and to analyse the association with socioeconomic factors and level of care in Swedish adults aged 20-34 years. METHODS:Individuals, aged 20-34 years, who purchased an antidepressant in Ja...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12263
更新日期:2013-12-01 00:00:00
abstract::Cystic fibrosis (CF) is one of the commonest lethal inherited conditions among Caucasians. It affects multiple organ systems and exhibits a range of clinical problems of varying severity. Life expectancy has improved in recent years as treatment regimes have become more intensive, but current treatments are expensive,...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:'Do Not Attempt Cardiopulmonary Resuscitation' (DNACPR) orders are made frequently for older people in hospital. Sensitive anticipatory discussion is encouraged where possible, but usually this does not happen, despite the evidence suggesting that many older patients would like to be involved in such decisio...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12067
更新日期:2013-04-01 00:00:00
abstract::Motor restlessness, characterised by an irresistible urge to move about, can be a manifestation of many underlying disorders. Unfortunately, it is often poorly recognised and underdiagnosed in clinical practice, possibly because patients do not seek medical attention, or their complaints were thought to be secondary t...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::This study was aimed to investigate the relationship between plasma fibrinogen level and risk for cognitive decline and dementia in patients with mild cognitive impairment (MCI). Elderly patients with suspected cognitive impairment were screened and evaluated periodically. One hundred and eighty-five patients who met ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01268.x
更新日期:2008-07-01 00:00:00
abstract::As a result of incessant genetic discoveries and remarkable technological advancements, the availability and the consequent consumer's request for genetic testing are growing exponentially, leading to the development of a 'parallel' market, i.e. the direct-to-consumer (DTC) testing, also known as 'direct access testin...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2011.02774.x
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:Peripartum cardiomyopathy (PPCM) is an uncommon form of congestive heart failure, afflicting obstetric patients around the time of delivery. The epidemiology of PPCM is infrequently reported. To the best of our knowledge, there has been no report from Asia. OBJECTIVE:To define the prevalence, presentation...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01449.x
更新日期:2009-05-01 00:00:00
abstract:AIMS:Early clinical trials suggest that blood-derived stem/progenitor cells (including peripheral blood-derived stem cells and circulating progenitor cells) may have a positive impact on patients with ischaemic heart disease (IHD). The therapeutic effects of these cells remain unclear, considering the inconsistent resu...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1742-1241.2011.02715.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:In late July, Cyprus experienced the second epidemic wave of COVID-19. We present the steps taken by the government and evaluate their effect on epidemic trends. MATERIALS:Cyprus Press and Information Office data were analysed. Using an R-based forecasting program, two models were created to predict cases u...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13944
更新日期:2020-12-18 00:00:00
abstract:BACKGROUND:In clinical practice, hyponatraemia was frequently found in patients with hydrocephalus. We conducted this study to determine the prevalence and risk factors for hyponatraemia in patients with normal pressure hydrocephalus (NPH). METHODS:We retrospectively reviewed all patients with NPH who were admitted to...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2008.01925.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). MATERIALS AND METHODS:We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13750
更新日期:2020-10-08 00:00:00
abstract::Prescriptions for short-acting beta(2)-agonists (SABAs) and oral corticosteroids recorded in a primary care database were used as markers of asthma control. Drug use in the 6 months before and after step-up in treatment from inhaled corticosteroids [ICs; total daily dosage of < or =1000 microg beclomethasone dipropion...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2005.00455.x
更新日期:2005-02-01 00:00:00
abstract::Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion in a dose-dependent manner via inhibition of H+/K+-adenosine triphosphatase in gastric parietal cells. It also exhibits antibacterial activity against Helicobacter pylori in vitro. During almost 10 years of clinical use, lansoprazole has prove...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2002-03-01 00:00:00
abstract::General practitioners (GPs) are increasingly involved in the selective opportunistic case finding of osteoporosis and treatment of this condition. An open access bone densitometry service has existed for GPs in the Cardiff area since 1993. The purpose of this study was to assess the effectiveness of this service, part...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2004.00151.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:This study aimed to determine the prevalence of gout in a general Turkish population, according to the American College of Rheumatology (Wallace) criteria proposed for gout classification. METHODS:This study was conducted in two districts of Izmir Province in Turkey, and involved 2835 subjects of ≥ 20 years...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12377
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The impact of robot-assisted techniques versus conventional freehand techniques in terms of the accuracy of pedicle screw placement remains conflicting. This meta-analysis was performed to evaluate this relationship. METHODS:A systematic literature search up to July 2020 was performed and 15 studies were de...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13964
更新日期:2020-12-28 00:00:00
abstract::Paliperidone, the 9-hydroxy metabolite of risperidone, was approved on 20 December, 2006 by the US Food and Drug Administration for the treatment of schizophrenia. It is also being tested for the treatment of bipolar mania. An on-line query of http://www.pubmed.gov and http://www.clinicaltrials.gov for 'paliperidone' ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01321.x
更新日期:2007-04-01 00:00:00
abstract:AIM:To assess the efficacy and safety of dipeptidyl peptidase 4-inhibitors (DPP4-I) compared with sulphonylureas in adults with type 2 diabetes (T2D) mellitus. METHOD:Randomised controlled trials were collected from PubMed, EMBASE, Google Scholar and conference. The primary outcome was the change in HbA1c. Secondary o...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ijcp.12761
更新日期:2016-02-01 00:00:00
abstract::We performed the present study to compare patients with migraine and tension-type headache (TTH) in their behaviour during the attacks and the manoeuvres to relieve the pain. One hundred thirty consecutive patients with either migraine (n = 75) or TTH (n = 55) were questioned (including the use of a checklist) concern...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2005.00535.x
更新日期:2005-07-01 00:00:00
abstract:AIM:To evaluate whether administration of long-acting basal insulin analogue plus oral antidiabetic drugs (OADs) improves glycaemic control in type 2 diabetic patients with glycosylated haemoglobin (HbA1c) > 7% (53 mmol/mol) under premixed insulin therapy. METHODS:This is a multicentre, observational, retrospective st...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-1241.2012.03000.x
更新日期:2012-10-01 00:00:00
abstract:AIMS:Intervention studies have shown that angiotensin receptor blockers (ARB) may reduce the incidence of type 2 diabetes mellitus. It is currently unclear whether short-term therapy with ARBs affects metabolic parameters. METHODS:i-RESPOND, a randomised, controlled, multicentre, double-blind study evaluated the effec...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-1241.2009.02246.x
更新日期:2010-01-01 00:00:00
abstract:AIM:To determine relative prevalence in the same population of urinary incontinence (UI), faecal incontinence (FI) and nocturnal enuresis (NE). To explore attitudes and behaviours relating to help-seeking and beliefs about incontinence prevalence, impact, causes and treatments. DESIGN:Online survey. SUBJECTS:A total ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2008.01974.x
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:Whilst core curricula in neurology are nationally standardised, in real-world clinical practice, different approaches may be taken by individual consultants. The aims of this study were to investigate differences by assessing: (a) variance in diagnostic and investigative practice, using a case-based analysis of...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13830
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND/OBJECTIVES:To conduct a comparative study of retinal nerve fibre layer (RNFL) thickness and choroidal thickness of psoriasis patients and healthy volunteers. METHODS:This study included 35 severe psoriasis patients, 35 mild psoriasis patients and 35 healthy individuals. RNFL and choroidal thickness analysis...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13904
更新日期:2020-12-08 00:00:00