Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions.

Abstract:

:This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via medline and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in subjects receiving SCH 1.0-1.5 mg/kg and RCR 0.6-1.2 mg/kg were determined using standard statistical methods. Inclusion criteria were met by 16 RCTs, representing 1362 subjects. SCH was associated with a 17.7% increase (95% CI = 13-22) in the frequency of excellent ETI conditions and a 5.1% decrease (95% CI = -7.3 to -2.9) in the frequency of unacceptable ETI conditions, when compared with RCR. In the subgroup undergoing true rapid sequence intubation, SCH was associated with a 19.1% increase (95% CI = 13.7-24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions.

journal_name

Int J Clin Pract

authors

Karcioglu O,Arnold J,Topacoglu H,Ozucelik DN,Kiran S,Sonmez N

doi

10.1111/j.1742-1241.2005.00685.x

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1638-46

issue

12

eissn

1368-5031

issn

1742-1241

pii

IJCP685

journal_volume

60

pub_type

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