Mode of action of urea.

abstract：BACKGROUND:The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported. AIMS:To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on g...

journal_title：International journal of clinical practice

authors： Tahrani AA,Ball A,Shepherd L,Rahim A,Jones AF,Bates A

更新日期：2010-02-01 00:00:00

abstract：:Monomeric prolactin (PRL) of molecular weight 23 kDa constitutes up to 95% of adult serum PRL. Macroprolactin is a large antigen-antibody complex of molecular weight greater than 100 kDa and constitutes less than 1% of circulating PRL. Thus, in most cases, hyperprolactinaemia is usually a result of high levels of mono...

journal_title：International journal of clinical practice

authors： Sadideen H,Swaminathan R

更新日期：2006-04-01 00:00:00

abstract：:Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them 'indefini...

journal_title：International journal of clinical practice

authors： Heidelbaugh JJ,Metz DC,Yang YX

更新日期：2012-06-01 00:00:00

abstract：:Day-case and short-stay thyroid surgery is carried out routinely around the world. In the UK longer postoperative stay is usually advocated to circumvent/identify potentially catastrophic complications following thyroidectomy. In the current climate of the National Health Service with focus on patient-centred service,...

journal_title：International journal of clinical practice

authors： Mirnezami R,Sahai A,Symes A,Jeddy T

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVES:This study evaluates the effectiveness, safety and costs of switching to a rilpivirine/emtricitabine/tenofovir disoproxil fumarate (RPV/FTC/TDF) regimen in treatment-experienced HIV-1-infected patients with sustained virological suppression. METHODS:Observational, prospective study. Study population include...

journal_title：International journal of clinical practice

authors： Arrabal-Durán P,Rodríguez-González CG,Chamorro-de-Vega E,Gijón-Vidaurreta P,Herranz-Alonso A,Sanjurjo-Sáez M

更新日期：2017-08-01 00:00:00

abstract：AIM:We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS:Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT ...

journal_title：International journal of clinical practice

authors： Ponce González MA,Mirón Rubio M,Mujal Martinez A,Estrada Cuxart O,Fiuza Perez D,Salas Reinoso L,Fernández Fabrellas E,Chiner Vives E

更新日期：2017-12-01 00:00:00

abstract：:Hypercalcemia can be an uncommon manifestation of various infections and malignancies in HIV-positive patients. A case of severe symptomatic hypercalcemia as the first sign of non-Hodgkin's lymphoma in a patient found later to be HIV positive is presented. Differential diagnosis of calcium disorders should include tes...

journal_title：International journal of clinical practice

authors： Lydakis C,Karalis I,Anifantakis K,Tzortzakakis E,Apostolakis T

更新日期：2004-11-01 00:00:00

abstract：:The UK National Health Service (NHS) currently spends in excess of £250 million per annum on angiotensin II receptor blockers (ARBs) for the treatment of hypertension and heart failure; with candesartan currently dominating the market. With the recent introduction of generic losartan, we set out to directly compare th...

journal_title：International journal of clinical practice

authors： Grosso AM,Bodalia PN,Macallister RJ,Hingorani AD,Moon JC,Scott MA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Mobile smart phones have become increasingly integrated into the practice of doctors and allied medical professionals. Recent studies suggest them to represent reservoirs for pathogens with potential to cause nosocomial infections. This study aimed to investigate the level of contamination on phones used on ...

journal_title：International journal of clinical practice

authors： Mark D,Leonard C,Breen H,Graydon R,O'Gorman C,Kirk S

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Incretin-based therapies offer another treatment option for patients with type 2 diabetes. Agents that provide glycaemic control in addition to attenuating cardiovascular disease (CVD) risk factors are important for diabetes management. This review will focus on the off-target effects of incretin-based thera...

journal_title：International journal of clinical practice

authors： Rotz ME,Ganetsky VS,Sen S,Thomas TF

更新日期：2015-05-01 00:00:00

abstract：:The effects of diltiazem treatment on symptoms of chronic anal fissures and their long-term outcome were investigated. One hundred and twelve patients were supplied with 6-week course of 2% diltiazem cream for twice-daily topical application. The medical notes and extended follow-up by telephone for 112 patients were ...

journal_title：International journal of clinical practice

authors： Nash GF,Kapoor K,Saeb-Parsy K,Kunanadam T,Dawson PM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:This study was designed to assess clinical and functional outcomes associated with switching to duloxetine treatment in patients with major depressive disorder (MDD) experiencing emotional and painful physical symptoms in their current episode. METHODS:In this 8-week, multinational, multicentre, single-arm,...

journal_title：International journal of clinical practice

authors： Sagman D,McIntosh D,Lee MS,Li H,Ruschel S,Hussain N,Granger RE,Lee AC,Raskin J

更新日期：2011-01-01 00:00:00

abstract：:Current and upcoming treatment options for premature ejaculation (PE) are of global clinical interest. In 2008, the International Society for Sexual Medicine published an evidence-based definition for PE. While there are no US Food and Drug Administration-approved therapies for PE, the American Urological Association ...

journal_title：International journal of clinical practice

authors： Hellstrom WJ

更新日期：2011-01-01 00:00:00

abstract：AIMS:To examine the relationship between costs of hyperglycaemia drug treatment and glycemic control amongst people with type 2 diabetes (T2D). METHODS:This observational study utilised data from the QUALIDIAB database on 3,452 T2D patients seen in Diabetes Centers in Argentina. Patients were classified according to t...

journal_title：International journal of clinical practice

authors： Elgart JF,Silvestrini C,Prestes M,Gonzalez L,Rucci E,Gagliardino JJ

更新日期：2019-04-01 00:00:00

abstract：:This study was aimed to investigate the relationship between plasma fibrinogen level and risk for cognitive decline and dementia in patients with mild cognitive impairment (MCI). Elderly patients with suspected cognitive impairment were screened and evaluated periodically. One hundred and eighty-five patients who met ...

journal_title：International journal of clinical practice

authors： Xu G,Zhang H,Zhang S,Fan X,Liu X

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Medication errors are a frequent cause of adverse drug events and a major concern for patient safety. This study compared the predictors of error among seven countries (Australia, Canada, New Zealand, the United Kingdom, the United States, Germany and the Netherlands). METHODS:We conducted a cross-sectional ...

journal_title：International journal of clinical practice

authors： Lu CY,Roughead E

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Although mild asthmatics form the majority of asthma sufferers, there is a relative paucity of evidence-based treatment compared with severe asthmatics. OBJECTIVE:We have performed an up-to-date review of the literature on therapy in this group of patients who form an overlooked but important majority. Pote...

journal_title：International journal of clinical practice

authors： Koh MS,Irving LB

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Guidelines for injury care are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. We aimed to assess inter-hospital variation in surgical intensity for injury admissions and evaluate the correl...

journal_title：International journal of clinical practice

authors： Patton MP,Moore L,Farhat I,Tardif PA,Gonthier C,Belcaid A,Lauzier F,Turgeon A,Clément J

更新日期：2020-11-01 00:00:00

abstract：:Coronary heart disease (CHD) is the leading cause of death worldwide, and effective treatment of hyperlipidaemia can prevent development of CHD and significantly reduce the risk for cardiovascular events and mortality in this disease. The advent of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (...

journal_title：International journal of clinical practice

authors： Hanefeld M

更新日期：2001-07-01 00:00:00

abstract：:Cases of transient global amnesia (TGA) seen by one consultant neurologist over a 4-year period (2002-2005 inclusive) were identified. Of 10 possible cases, eight fulfilled suggested diagnostic criteria. Five cases were seen as ward consultations, three in outpatient clinics; seven were seen in district general hospit...

journal_title：International journal of clinical practice

authors： Larner AJ

更新日期：2007-02-01 00:00:00

abstract：:This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via medline and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in...

journal_title：International journal of clinical practice

authors： Karcioglu O,Arnold J,Topacoglu H,Ozucelik DN,Kiran S,Sonmez N

更新日期：2006-12-01 00:00:00

abstract：:Overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology of heart failure (HF) and chronic kidney disease (CKD). RAAS antagonists can significantly improve clinical outcomes, but monotherapy blocks but one step of the RAAS and can be bypassed through compensatory mechanis...

journal_title：International journal of clinical practice

authors： Ziff OJ,Covic A,Goldsmith D

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Overactive bladder (OAB) syndrome has a diverse etiology that disrupts quality of life domains in affected patients. OAB is significantly under-recognised and undertreated, especially in the primary care setting. In order to educate primary care providers about OAB recognition, evaluation and management, we ...

journal_title：International journal of clinical practice

authors： Turell W,Howson A,MacDiarmid SA,Rosenberg MT

更新日期：2020-11-01 00:00:00

abstract：:This randomised, double-blind study compared the anti-hypertensive efficacy and tolerability of Candesartan cilexetil (CC 8-16 mg) and Amlodipine (AML 5-10 mg) on home blood pressure (HBP) measurements in mild-to-moderate hypertensive patients. After a 2-week wash-out, patients aged 18-74 years, with a sitting diastol...

journal_title：International journal of clinical practice

authors： Imbs JL,Nisse-Durgeat S,French Collaborative Candesartan Study Group.

更新日期：2005-01-01 00:00:00

abstract：:The clinical syndrome of anaphylaxis and anaphylactoid reactions is quite variable, making diagnosis difficult at times. Early recognition by patient or physician is imperative to appropriate management. Recurrences may be life-threatening if the initial diagnosis is incorrect, as patients do not avoid the offending a...

journal_title：International journal of clinical practice

authors： Murrant T,Bihari D

更新日期：2000-06-01 00:00:00

abstract：AIMS:To describe the mechanisms of action of denosumab, a novel antiresorptive agent, contrasting it with other antiresorptive and anabolic osteoporosis treatments. METHODS:Published papers related to the mechanism of action of approved osteoporosis treatments were sought through MEDLINE searches. FINDINGS:Osteoporot...

journal_title：International journal of clinical practice

authors： Hanley DA,Adachi JD,Bell A,Brown V

更新日期：2012-12-01 00:00:00

abstract：:Despite potential benefits, primary care clinicians may avoid using antimuscarinics in men with overactive bladder (OAB) symptoms because of safety concerns. To review the efficacy and safety of antimuscarinics, alone or in combination with an α-blocker, for the treatment of men with OAB symptoms, we conducted a syste...

journal_title：International journal of clinical practice

authors： Kaplan SA,Roehrborn CG,Abrams P,Chapple CR,Bavendam T,Guan Z

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Subjects with the metabolic syndrome are accompanied by insulin resistance (IR). However, it is not clear how well the newly defined metabolic syndrome identifies IR specifically in hypertensive subjects. AIMS:The purpose of the study was to evaluate the performance of the metabolic syndrome, defined by the...

journal_title：International journal of clinical practice

authors： Hwu CM,Hsiung CA,Wu KD,Lee WJ,Shih KC,Grove J,Chen YD,Rodriguez BL,Curb JD,SAPPHIRe Study Group.

更新日期：2008-09-01 00:00:00

abstract：:Although uric acid (UA) is considered as an antioxidant, the relationship between serum UA levels and cardiovascular diseases is not clear yet. Higher brachial artery resting diameter (BD), impaired brachial artery flow-mediated dilatation (FMD), increased carotid intima-media thickness (IMT), decreased aortic distens...

journal_title：International journal of clinical practice

authors： Erdogan D,Gullu H,Caliskan M,Yildirim E,Bilgi M,Ulus T,Sezgin N,Muderrisoglu H

更新日期：2005-11-01 00:00:00

abstract：:Manifestations of atypical gastroesophageal reflux disease (GORD) are varied, and the presentation of atypical symptoms may occur in the absence of typical symptoms. The most sensitive and specific investigation for GORD is pH monitoring, and its application in atypical disease is utilized throughout this paper as a b...

journal_title：International journal of clinical practice

authors： Chandra A,Moazzez R,Bartlett D,Anggiansah A,Owen WJ

更新日期：2004-01-01 00:00:00