Abstract：
:Monomeric prolactin (PRL) of molecular weight 23 kDa constitutes up to 95% of adult serum PRL. Macroprolactin is a large antigen-antibody complex of molecular weight greater than 100 kDa and constitutes less than 1% of circulating PRL. Thus, in most cases, hyperprolactinaemia is usually a result of high levels of monomeric PRL, which may be due to excess production as with a prolactinoma or due to disinhibition by compression of the pituitary stalk. Nevertheless, it must be noted that macroprolactinaemia may be a cause of hyperprolactinaemia in some individuals, which may have no association with any pathology. The presence of macroprolactin should always be suspected when a patient's clinical history and/or radiological data are incompatible with his/her PRL value. Thus, it may be useful to screen all patients with high sera PRL levels in order to prevent unnecessary investigations into the cause for hyperprolactinaemia. This has recently been facilitated with the advent of simple laboratory tests such as the polyethyleneglycol precipitation method, although gel filtration chromatography remains the gold standard. It is hoped that macroprolactinaemia is included in the differential diagnosis of hyperprolactinaemia.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Sadideen H,Swaminathan Rdoi
10.1111/j.1368-5031.2006.00732.xsubject
Has Abstractpub_date
2006-04-01 00:00:00pages
457-61issue
4eissn
1368-5031issn
1742-1241pii
IJCP732journal_volume
60pub_type
杂志文章,评审abstract：:We report a case of Pott's puffy tumour in a 12-year-old. Owing to the late development of the frontal sinuses, frontal sinus infection in children is rare. When present it can lead to osteomyelitis associated with forehead swelling. Early diagnosis and active treatment prevent progression to life-threatening intracra...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:Some chiropractors claim that spinal manipulation is an effective treatment for infant colic. This systematic review was aimed at evaluating the evidence for this claim. Four databases were searched and three randomised clinical trials met all the inclusion criteria. The totality of this evidence fails to demonstrate ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02133.x
更新日期：2009-09-01 00:00:00
abstract：:Nitrates are useful drugs in cardiovascular medicine. They have a presumed vasovagal effect, which is a rare but often under-recognised complication that is partly caused by central inhibition of the sympathetic nervous system. However, no consistent variable associated with the presumed vasovagal effects following ni...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2006.01101.x
更新日期：2006-09-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2004.00035.x
更新日期：2004-07-01 00:00:00
abstract：:Graham Jackson introduced the concept that erectile dysfunction was a marker for undiagnosed cardiovascular disease and future events. Unfortunately this had had modest impact on CVD management as ED is not incorporated into current risk calculators. In this paper, we examine recent evidence as to whether ED should be...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13054
更新日期：2018-02-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12968
更新日期：2017-08-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12543
更新日期：2015-02-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2008.01709.x
更新日期：2008-04-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1742-1241.2009.02022.x
更新日期：2009-04-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13410
更新日期：2019-08-29 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2004.00180.x
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journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-04-01 00:00:00
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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更新日期：2017-12-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2010.02384.x
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) has had a rapid global spread. All individuals of all age groups are at risk of COVID-19. This study aims to describe the knowledge and attitude of Jordanian parents regarding COVID-19 in children, including clinical signs of the disease, modes of transmission and prot...
journal_title：International journal of clinical practice
pub_type： 杂志文章
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journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-01-01 00:00:00
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journal_title：International journal of clinical practice
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