Abstract:
:High plasminogen activator inhibitor-1 (PAI-1) levels are potential risk factors for cardiovascular disease. The risk profile of white coat hypertension (WCHT) has not yet been completely clear. In this study, we aimed to determine the plasma levels of PAI-1, markers of fibrinolysis and increased cardiovascular disease risk, in a group with WCHT and to obtain clinical results by comparing WCHT group with hypertensive and healthy groups. Age and sex matched 30 patients with WCHT, 30 patients with sustained hypertension, and 30 healthy subjects were included in the study. The plasma levels of PAI-1 were significantly higher in sustained hypertension group than in WCHT group (p < 0.01). There were significantly higher levels in patients with WCHT than in control group (p < 0.01). Our data suggests one possible mechanism by which WCHT subjects may be at increased cardiovascular risk.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Coban E,Ozdogan Mdoi
10.1111/j.1368-5031.2004.00119.xsubject
Has Abstractpub_date
2004-06-01 00:00:00pages
541-4issue
6eissn
1368-5031issn
1742-1241journal_volume
58pub_type
杂志文章abstract::To investigate ethnic differences and the effect of age and education on awareness and attitudes of women towards hormone replacement therapy (HRT), we conducted a questionnaire survey of 180 women attending a gynaecology clinic, of whom 152 (84.4%) responded. Seventy-one of the women had heard of HRT. Awareness of HR...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated the beneficial effect of normal and high body mass index (BMI) upon risk of osteoporosis (OP). No study has investigated the prevalence of OP in an older population with a very high BMI (higher than 40 kg/m(2) ). METHODS:Data of patients aged over 50 years that attended for a dual ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12371
更新日期:2014-06-01 00:00:00
abstract::People in a first episode of psychosis are receiving increasing attention. This study describes the demographic and clinical diagnostic features of a cohort of 84 cases of first episode psychosis presenting in North Derbyshire from October 1999 to October 2000. Forty-two cases falling within the schizophrenia spectrum...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is common in older age and in diabetes mellitus (DM). Phosphodiesterase type 5-inhibitors (PDE5-is) are the first-line for ED. We investigated how the type of diabetes and age of males affect the PDE5-i use in the primary care setting. METHODS:From 2018 to 2019, the general pract...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13538
更新日期:2020-09-01 00:00:00
abstract:AIMS:To describe trends and outcomes during admission for solid organ transplant in people with or without type 2 diabetes in Spain, 2001-2015. METHODS:We used national hospital discharge data to select all hospital admissions for kidney, lung, heart, and liver transplant. We estimated admission rates stratified by ty...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13283
更新日期:2018-10-13 00:00:00
abstract::TT virus (TTV) is a novel DNA virus that has been identified in patients with post-transfusional hepatitis of unknown aetiology. However, its pathogenic role in liver injury remains unclear. To determine its frequency and clinical impact in cryptogenic liver diseases, we investigated the TTV prevalence in patients wit...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::This study was aimed to investigate the relationship between plasma fibrinogen level and risk for cognitive decline and dementia in patients with mild cognitive impairment (MCI). Elderly patients with suspected cognitive impairment were screened and evaluated periodically. One hundred and eighty-five patients who met ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01268.x
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Computed tomography (CT) can be effective for the early screening and diagnosis of COVID-19. This study aimed to investigate the distinctive CT characteristics of two stages of the disease (progression and remission). METHODS:We included all COVID-19 patients admitted to Wenzhou Central Hospital from Janu...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13760
更新日期:2020-10-17 00:00:00
abstract:AIM:Osteoporosis and sarcopenia are common health problems in postmenopausal women. However, studies of these issues in premenopausal women are limited. Our present study aimed to investigate relationship the between underweight, bone mineral density (BMD) and skeletal muscle index (SMI) in a representative sample of p...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12801
更新日期:2016-06-01 00:00:00
abstract:AIM:Infection is a major cause of increased mortality after a liver transplant (LT). This study sought to identify the incidence, prevalence and risk factors of microbial infection for recipients who underwent LT using grafts from donors after cardiac death (DCD). METHODS:We retrospectively analysed the frequency and ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12812
更新日期:2016-06-01 00:00:00
abstract::Lithium salts have been used in medicine for over a century and are a widely accepted treatment. Clinical practice in the London borough of Barnet led us to suspect that agreed guidelines were not being followed. We checked them against published guidelines and followed up their implementation. A list of patients on l...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::Patients with severely increased blood pressure often present to the emergency department. Rapid lowering of blood pressure can precipitate or worsen end organ damage. We report two cases that developed cerebrovascular and cardiovascular adverse events associated with aggressive treatment of increased blood pressure b...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2004.00171.x
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess secondary prevention of fragility fractures by orthopaedic surgeons in the UK and study the effect of multidisciplinary approach in providing secondary prevention. METHODS:A survey was conducted consisting of a postal questionnaire sent to 1000 UK orthopaedic surgeons. 750 valid responses were rece...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01662.x
更新日期:2008-03-01 00:00:00
abstract::The phenomenon of spontaneous remission is one of the less well known aspects of the leukaemias. Spontaneous remission has been reported in both acute and chronic leukaemia. The mechanism is unclear but may involve immune modulation related to an intercurrent infection or transfusion of blood products. We present a ra...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::After more than 20 years, the conflict of interest (COI) movement has failed to substantiate its central claim that interactions between physicians, researchers and the medical products industry cause physicians to make clinical decisions that are adverse to the best interests of their patients. The COI movement's ins...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12366
更新日期:2014-06-01 00:00:00
abstract::Sotos syndrome is characterised by accelerated growth, acromegalic appearance, mental retardation and social maladjustment. Most cases are sporadic, but familial cases have also been reported. We report a case of Sotos syndrome presenting with chronic renal failure due to autosomal dominant polycystic kidney disease (...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:Whilst core curricula in neurology are nationally standardised, in real-world clinical practice, different approaches may be taken by individual consultants. The aims of this study were to investigate differences by assessing: (a) variance in diagnostic and investigative practice, using a case-based analysis of...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13830
更新日期:2020-11-12 00:00:00
abstract:AIMS:To investigate the evolution of the quality of life of patients with chronic obstructive pulmonary disease (COPD) and quantify the impact of exacerbations on the deterioration of quality of life over 2 years. METHODS:Multicentre, observational, prospective 2-year study carried out in primary care. Patients with C...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-1241.2008.01707.x
更新日期:2008-04-01 00:00:00
abstract::Primary intracranial melanomas are rare and occur mainly in young adults. Originating from leptomeningeal melanoblasts and extending into the parenchyma, the tumours closely resemble meningiomas, from which they are radiologically difficult to distinguish despite progress in neuroimaging. Definitive diagnosis is usual...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathophysiology of heart failure (HF) and chronic kidney disease (CKD). RAAS antagonists can significantly improve clinical outcomes, but monotherapy blocks but one step of the RAAS and can be bypassed through compensatory mechanis...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/ijcp.12803
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Complementary medicine and alternative approaches to chronic and intractable health conditions are increasingly being used, and require critical evaluation. OBJECTIVE:The aim of this review was to systematically evaluate available evidence for the effectiveness and safety of instruction in the Alexander Tec...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2011.02817.x
更新日期:2012-01-01 00:00:00
abstract::There has been much debate over the past 50 years concerning the association between colorectal carcinoma and inflammatory bowel disease. Until recently, it was widely accepted there was a higher risk in those with widespread ulcerative colitis. However, evidence now suggests an almost equal incidence in those with Cr...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Patient-controlled sedation (PCS) with propofol has been used successfully in various conditions, but controversies exist about its use in sedation of elderly patients for cataract surgery. This study evaluates the efficacy of anaesthetic nurse-controlled sedation (ACS) compared with PCS using the same devic...
journal_title:International journal of clinical practice
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1742-1241.2007.01544.x
更新日期:2008-05-01 00:00:00
abstract::The current lack of sufficient evidence of vitamin D's role in CVD calls for perspective and caution to avoid that health claims, vitamin D testing and supplementations' sales will continue to run well ahead of the scientific evidence. ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12197
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The decision on whether or not to treat a first seizure is dependent on several medical and non-medical factors. AIMS:In this review, we have summarised the important aspects that determine the advantages and disadvantages of treating a first seizure. We have looked at evidence from randomised controlled tr...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2008.01896.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To describe the efficacy and safety of asenapine for the treatment of schizophrenia and bipolar disorder. DATA SOURCES:The pivotal registration trials were accessed by querying http://www.pubmed.gov, http://www.fda.gov and http://www.clinicaltrials.govfor the search terms 'asenapine' or 'ORG 5222'. STUDY SE...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1742-1241.2009.02228.x
更新日期:2009-12-01 00:00:00
abstract::This open multicentre study compared the efficacy and tolerability of clarithromycin and spiramycin in the treatment of lower respiratory tract infections in Brazil and Colombia. A total of 125 patients with a clinical and radiological diagnosis of pneumonia, acute bronchitis or exacerbation of chronic bronchitis were...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Systolic aortic regurgitation (SAR) is a curious phenomenon that has been found to be associated with heart failure (HF). We aimed to determine de diagnostic value of SAR as a black box predictive tool in patients with suspected HF admitted to hospital with dyspnea as leading symptom. METHODS AND RESULTS:Cr...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12566
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Urinary tract infections (UTI) and asymptomatic bacteriuria (AB) during pregnancy can result in considerable maternal and foetal adverse outcomes. Production of extended-spectrum beta-lactamase (ESBL) is a major antibiotic resistance mechanism by Enterobacteriaceae. OBJECTIVES:To determine the global preval...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13422
更新日期:2019-09-18 00:00:00
abstract::Zoledronic acid inhibits bone resorption for up to 12 months. It is not known whether the duration of this antiresorptive effect extends beyond this period of time. The aim of this study was to evaluate the changes in bone turnover at 12 months (T12) and 18 months (T18) after a single injection of 4 mg of zoledronic a...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01392.x
更新日期:2007-06-01 00:00:00