The plasma levels of plasminogen activator inhibitor-1 in subjects with white coat hypertension.

Abstract:

:High plasminogen activator inhibitor-1 (PAI-1) levels are potential risk factors for cardiovascular disease. The risk profile of white coat hypertension (WCHT) has not yet been completely clear. In this study, we aimed to determine the plasma levels of PAI-1, markers of fibrinolysis and increased cardiovascular disease risk, in a group with WCHT and to obtain clinical results by comparing WCHT group with hypertensive and healthy groups. Age and sex matched 30 patients with WCHT, 30 patients with sustained hypertension, and 30 healthy subjects were included in the study. The plasma levels of PAI-1 were significantly higher in sustained hypertension group than in WCHT group (p < 0.01). There were significantly higher levels in patients with WCHT than in control group (p < 0.01). Our data suggests one possible mechanism by which WCHT subjects may be at increased cardiovascular risk.

journal_name

Int J Clin Pract

authors

Coban E,Ozdogan M

doi

10.1111/j.1368-5031.2004.00119.x

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

541-4

issue

6

eissn

1368-5031

issn

1742-1241

journal_volume

58

pub_type

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