Abstract：
:This study was aimed to investigate the relationship between plasma fibrinogen level and risk for cognitive decline and dementia in patients with mild cognitive impairment (MCI). Elderly patients with suspected cognitive impairment were screened and evaluated periodically. One hundred and eighty-five patients who met the criteria for MCI were enrolled. Blood coagulation functions and plasma fibrinogen levels were measured at baseline. Hyperfibrinogenaemia was defined as plasma fibrinogen > or =3.0 g/l. Global cognitive function was assessed serially with Mini-Mental State Examination (MMSE). The enrolled patients were followed for 2 years to observe if dementia was developed. There were 185 patients diagnosed as MCI, of which 17 (9.2%) deceased, 15 (8.1%) lost to follow-up, and 68 (36.8%) developed dementia during follow-up. Mean of MMSE score of the enrolled patients declined significantly during follow-up (22.0 +/- 3.0 vs. 18.1 +/- 5.8, p < 0.001). Patients with hyperfibrinogenaemia at baseline had greater MMSE decrement during follow-up than patients with normal fibrinogen level (-5.4 +/- 5.4 vs. -3.5 +/- 4.5, p < 0.05). Linear regression indicated that plasma fibrinogen level was associated with cognitive decline (R = 0.17, p < 0.05). Patients with hyperfibrinogenaemia had an increased risk for dementia and vascular dementia compared with patients with normal level of plasma fibrinogen (log rank test, p < 0.05). There was a trend that hyperfibrinogenaemia also increased risk for dementia of Alzheimer's type (p = 0.061). It can be concluded that plasma fibrinogen level may be associated with cognitive decline, and hyperfibrinogenaemia may increase risk for dementia in patients with MCI.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Xu G,Zhang H,Zhang S,Fan X,Liu Xdoi
10.1111/j.1742-1241.2007.01268.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
1070-5issue
7eissn
1368-5031issn
1742-1241pii
IJCP1268journal_volume
62pub_type
杂志文章abstract：AIM:We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS:Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.13022
更新日期：2017-12-01 00:00:00
abstract：:Adult Indonesian outpatients were randomised to receive either valsartan 80 mg once daily or captopril 25 mg twice daily for 8 weeks. The main criterion for tolerability was the incidence of adverse events. The primary efficacy variable was the change in mean sitting diastolic blood pressure (SDBP) from baseline to en...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1999-06-01 00:00:00
abstract：:This randomised, double-blind, placebo-controlled, parallel-group study compared the efficacy and tolerability of lumiracoxib (a novel COX-2 selective inhibitor) with rofecoxib, celecoxib and placebo in patients with moderate-to-severe post-operative dental pain. Following third molar extraction, patients received sin...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1368-5031.2004.00155.x
更新日期：2004-03-01 00:00:00
abstract：:This double-blind, randomised, controlled study compared the efficacy of candesartan cilexetil 8 mg (n = 87) and losartan 50 mg (n = 89), once daily for 6 weeks, relative to placebo (n = 80) in patients with mild-to-moderate essential hypertension (diastolic blood pressure (DBP): 95-115 mmHg). Ambulatory BP measuremen...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1368-5031.2006.00903.x
更新日期：2006-04-01 00:00:00
abstract：:We report an unusual presentation of non-Hodgkin's lymphoma of the thyroid which mimicked an acute infective thyroiditis and was associated with acute stridor and dysphagia. The mode of presentation and diagnosis of thyroid lymphoma are discussed and the value of early fine needle aspiration emphasised. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：AIM:To determine relative prevalence in the same population of urinary incontinence (UI), faecal incontinence (FI) and nocturnal enuresis (NE). To explore attitudes and behaviours relating to help-seeking and beliefs about incontinence prevalence, impact, causes and treatments. DESIGN:Online survey. SUBJECTS:A total ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2008.01974.x
更新日期：2009-04-01 00:00:00
abstract：:In this journal, Cummins et al reported an experiment that examined clinicians' predictions of causes of death from subjects' pre-morbid photographs. They found that clinicians performed at chance. The validity of two of their other conclusions are challenged. First, that clinicians routinely form impressions of how a...
journal_title：International journal of clinical practice
pub_type： 评论,杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Primary intracranial melanomas are rare and occur mainly in young adults. Originating from leptomeningeal melanoblasts and extending into the parenchyma, the tumours closely resemble meningiomas, from which they are radiologically difficult to distinguish despite progress in neuroimaging. Definitive diagnosis is usual...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:People in a first episode of psychosis are receiving increasing attention. This study describes the demographic and clinical diagnostic features of a cohort of 84 cases of first episode psychosis presenting in North Derbyshire from October 1999 to October 2000. Forty-two cases falling within the schizophrenia spectrum...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The effects of diltiazem treatment on symptoms of chronic anal fissures and their long-term outcome were investigated. One hundred and twelve patients were supplied with 6-week course of 2% diltiazem cream for twice-daily topical application. The medical notes and extended follow-up by telephone for 112 patients were ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2006.00895.x
更新日期：2006-11-01 00:00:00
abstract：:The UK National Health Service (NHS) currently spends in excess of £250 million per annum on angiotensin II receptor blockers (ARBs) for the treatment of hypertension and heart failure; with candesartan currently dominating the market. With the recent introduction of generic losartan, we set out to directly compare th...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2011.02633.x
更新日期：2011-03-01 00:00:00
abstract：:This prospective study describes and evaluates the efficacy of an integrated care pathway for the management of the critically ischaemic diabetic foot patients by a multidisciplinary team. A weekly joint diabetes/vascular/podiatry ward round and outpatient clinic was established where patients were assessed within 7 d...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2006.00953.x
更新日期：2006-06-01 00:00:00
abstract：:Calcium dobesilate (Doxium) is used in the treatment of diabetic retinopathy. Clinical studies show a slowdown of the progression of the disease after long-term oral treatment. The main action of the drug is related to a reduction of microvascular permeability as measured by different parameters and methods (vitreous ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Hypercalcemia can be an uncommon manifestation of various infections and malignancies in HIV-positive patients. A case of severe symptomatic hypercalcemia as the first sign of non-Hodgkin's lymphoma in a patient found later to be HIV positive is presented. Differential diagnosis of calcium disorders should include tes...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2004.00055.x
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:This study compared effectiveness of rosuvastatin (RSV) with other statins on lowering LDL-C and LDL-C goal attainment among Medicare-eligible patients (age >or= 65 years) and patients with age < 65 years treated in usual clinical practice to provide evidence of real-world effectiveness of statins. METHODS:R...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2007.01538.x
更新日期：2007-10-01 00:00:00
abstract：:Men with cardiovascular disease (CVD) are more likely to have erectile dysfunction (ED) than the general population, as both conditions share risk factors and some drugs used to treat CVD may induce ED as a side-effect. This study was undertaken to assess the efficacy and safety of sildenafil citrate for the treatment...
journal_title：International journal of clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-04-01 00:00:00
abstract：:Twenty cases of tuberculous meningitis were diagnosed at the Hamad Medical Corporation between 1990 and 1995. Most of the patients (90%) were expatriates. The most common presenting features were fever, headache, neck stiffness and altered mental status. Five patients were in stage 1 disease at the time of presentatio...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis and steatohepatitis to cirrhosis. Based on its strongest risk factors namely visceral obesity and insulin resistance, NAFLD is thought to be the hepatic manifestation of the metabolic syndrome and is considered to be t...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2009.02327.x
更新日期：2010-06-01 00:00:00
abstract：:The use of hormone replacement therapy (HRT) for cardiovascular risk reduction remains uncertain. Although previous epidemiological surveys have suggested a clear benefit and nearly 50% mortality risk reduction with HRT in postmenopausal women, recent randomised trials have largely failed to support this. The epidemio...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：:The wide variation in the way coronary artery disease (CAD) affects different ethnic groups and the associated risk factor profiles of these groups have been extensively studied, but ethnic differences in the clinical manifestations of peripheral vascular disease (PVD) have been relatively neglected. The aim of the pr...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2002-10-01 00:00:00
abstract：AIMS:To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia. METHODS:A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treat...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12954
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Although the relationship of elevated serum uric acid levels and cardiovascular disease has been established in a great number of studies, the causal relevance of this finding remains ambiguous. An approach to evaluate the causal relevance of biomarkers is to exploit the natural randomised allocation of alle...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.13048
更新日期：2018-01-01 00:00:00
abstract：:Objectives: The purpose of this updated meta-analysis was to determine whether exercise training reversed left ventricular remodelling in heart failure patients. Methods: Articles were searched in MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, EMBASE and PubMed (up until October, 2011). The anti-re...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2012.02942.x
更新日期：2012-08-01 00:00:00
abstract：:Hypogonadism may play a significant role in the pathophysiology of erectile dysfunction (ED). A threshold level of testosterone may be necessary for normal erectile function. Testosterone replacement therapy is indicated in hypogonadal patients and is beneficial in patients with ED and hypogonadism. Monotherapy with t...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2006.01101.x
更新日期：2006-09-01 00:00:00
abstract：AIMS:To describe trends and outcomes during admission for solid organ transplant in people with or without type 2 diabetes in Spain, 2001-2015. METHODS:We used national hospital discharge data to select all hospital admissions for kidney, lung, heart, and liver transplant. We estimated admission rates stratified by ty...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13283
更新日期：2018-10-13 00:00:00
abstract：OBJECTIVE:To describe the efficacy and safety of asenapine for the treatment of schizophrenia and bipolar disorder. DATA SOURCES:The pivotal registration trials were accessed by querying http://www.pubmed.gov, http://www.fda.gov and http://www.clinicaltrials.govfor the search terms 'asenapine' or 'ORG 5222'. STUDY SE...
journal_title：International journal of clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1742-1241.2009.02228.x
更新日期：2009-12-01 00:00:00
abstract：:Graham Jackson introduced the concept that erectile dysfunction was a marker for undiagnosed cardiovascular disease and future events. Unfortunately this had had modest impact on CVD management as ED is not incorporated into current risk calculators. In this paper, we examine recent evidence as to whether ED should be...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13054
更新日期：2018-02-01 00:00:00
abstract：:We report a case of Pott's puffy tumour in a 12-year-old. Owing to the late development of the frontal sinuses, frontal sinus infection in children is rare. When present it can lead to osteomyelitis associated with forehead swelling. Early diagnosis and active treatment prevent progression to life-threatening intracra...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：AIMS:To analyse the predictive capacity of 15 machine learning methods for estimating cardiovascular risk in a cohort and to compare them with other risk scales. METHODS:We calculated cardiovascular risk by means of 15 machine-learning methods and using the SCORE and REGICOR scales and in 38 527 patients in the Spanis...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13389
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:Assess and categorise the available prevalence data on coexistent LUTS and ED in the general population and among individuals consulting a healthcare provider for any reason or when seeking treatment for LUTS and/or ED. METHODS:Literature search of English-language articles published during the last 15 years...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.12044
更新日期：2013-01-01 00:00:00
