Abstract:
AIM:Infection is a major cause of increased mortality after a liver transplant (LT). This study sought to identify the incidence, prevalence and risk factors of microbial infection for recipients who underwent LT using grafts from donors after cardiac death (DCD). METHODS:We retrospectively analysed the frequency and characteristics of post-transplantation infections in 236 recipients who underwent DCD LT between 1 January 2010 and 31 December 2014 in our centre and evaluated the risk factors of post-transplantation infection. RESULTS:Overall, 162 recipients acquired at least one type of infection during hospitalisation after LT, and the morbidity rate was 68.6%. Moreover, 19 of the 236 recipients died, with an overall mortality rate of 8.1%. In total, 752 pathogens were isolated. Gram-positive bacteria, Gram-negative bacteria and fungi accounted for 26.1% (196), 58.2% (438) and 15.7% (118) of the pathogens, respectively. Kaplan-Meier curves of 1-year survival showed that recipients with infection had a significantly lower cumulative survival rate compared with those without infection (83.2% vs. 90.6%, p < 0.05). Multivariate analysis revealed that age > 60 years (p = 0.010) and severe hepatitis (p = 0.036) were independent risk factors for infection during hospitalisation after LT. CONCLUSION:Infection is a common complication after a DCD-LT that could impair 1-year survival. We suggest physicians pay more attention to the infection of recipients post-LT, especially those recipients greater than 60 years of age and those who suffered from severe hepatitis.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Zhang ML,Xu J,Zhang W,Liu XY,Zhang M,Wang WL,Zheng SSdoi
10.1111/ijcp.12812subject
Has Abstractpub_date
2016-06-01 00:00:00pages
17-21eissn
1368-5031issn
1742-1241journal_volume
70 Suppl 185pub_type
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journal_title:International journal of clinical practice
pub_type: 评论,杂志文章
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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pub_type: 杂志文章,评审
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
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journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章
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