Abstract:
:Cigarette smoking induces a significant oxidant effect related to variety of free radical-related diseases often affecting the upper respiratory tract, unless it is effectively compensated by the antioxidant barriers of the humans. In the present study, the evaluation of the antioxidant compensatory mechanisms, by estimating the antioxidant capacity of extracellular defence (saliva and plasma) and the intracellular resistance of peripheral lymphocytes to oxidative stress in young healthy smokers, was investigated. Twenty young healthy male smokers and 20 age-matched non-smokers with similar dietary profiles were enrolled in the study. Total saliva and plasma samples were collected from both groups, and total antioxidant capacity (TAC) and lag time were estimated. The latter was also repeated in smokers just after a cigarette smoking. Peripheral lymphocytes isolated from the subjects of both groups were also tested for their inherent DNA damage as well as for their ability to resist H2O2-induced DNA damage by using the comet assay. TAC of plasma was found significantly higher in smokers compared to non-smokers (p <0.004), whereas no difference was recorded in plasma lag time values. Lymphocytes of smokers manifested a significantly decreased oxidant resistance (increased DNA fragmentation) to H2O2, in comparison to non-smokers. Our results indicate that young smokers do not manifest different salivary antioxidant defence than non-smokers. They exhibit, however, a higher plasma antioxidant capacity, but a significantly reduced ability of blood lymphocytes, to resist to H2O2-induced DNA damage.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Charalabopoulos K,Assimakopoulos D,Karkabounas S,Danielidis V,Kiortsis D,Evangelou Adoi
10.1111/j.1742-1241.2004.00340.xsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
25-30issue
1eissn
1368-5031issn
1742-1241pii
IJCP340journal_volume
59pub_type
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journal_title:International journal of clinical practice
pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:People with depressive disorders or subsyndromal symptoms of depression (SSD) often use complementary and alternative therapies, including massage therapy (MT). This systematic review evaluates the evidence, from randomised clinical trials (RCTs), for the effectiveness of multiple sessions of classical Europ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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abstract::To investigate the influence of the S447X variant in lipoprotein lipase (LPL) gene on the response rate to therapy with the thiazolidinedione pioglitazone. A total of 113 diabetic patients were treated with pioglitazone 30 mg for 10 weeks. Response to the pioglitazone treatment was defined by either a >10% relative re...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章
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更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate the use of computed tomography (CT) as the first imaging modality in patients with renal colic and microscopic haematuria. METHODOLOGY:The patients that presented to the emergency service of six health centers with renal colic between January 2017 and January 2018 and were found to have ...
journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:1997-07-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2001-04-01 00:00:00
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更新日期:2019-08-29 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/ijcp.12044
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-09-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2006.01136.x
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pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
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更新日期:2009-07-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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更新日期:2003-04-01 00:00:00
abstract::It is becoming increasingly common to offer primary percutaneous coronary intervention as first line treatment for ST elevation myocardial infarction (STEMI). In a subset of patients presenting with suspected STEMI, coronary arteries appear normal at coronary angiography. In this article, the current literature of thi...
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