Abstract:
AIMS/OBJECTIVES:In the BESIDE study, combination therapy (antimuscarinic [solifenacin] and β3 -adrenoceptor agonist [mirabegron]) improved efficacy over solifenacin monotherapy without exacerbating anticholinergic side effects in overactive bladder (OAB) patients; however, a potential synergistic effect on the cardiovascular (CV) system requires investigation. METHODS:OAB patients remaining incontinent despite daily solifenacin 5 mg during 4-week single-blind run-in, were randomised 1:1:1 to double-blind daily combination (solifenacin 5 mg/mirabegron 25 mg, increasing to 50 mg after week 4), solifenacin 5 or 10 mg for 12 weeks. CV safety assessments included frequency of CV-related treatment-emergent adverse events (TEAEs), change from baseline in vital signs (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse rate) and electrocardiogram (ECG) parameters. RESULTS:The frequency of hypertension, tachycardia and ECG QT prolongation, respectively, was low and comparable across combination (1.1%, 0.3%, 0.1%), solifenacin 5 mg (0.7%, 0.1%, 0.1%), and solifenacin 10 mg groups (0.8%, 0%, 0.1%). Adjusted mean (SE) change from baseline to end of treatment (EoT) in SBP, DBP, and pulse rate with combination (0.07 mm Hg [0.38], -0.35 mm Hg [0.26], 0.47 bpm [0.28]), solifenacin 5 mg (-0.93 mm Hg [0.38], -0.45 mm Hg [0.26], 0.43 bpm [0.28]) and solifenacin 10 mg (-1.28 mm Hg [0.38], -0.48 mm Hg [0.26], 0.27 bpm [0.28]) was generally comparable, with the exception of a mean treatment difference of ~1 mm Hg in SBP between combination and solifenacin monotherapy; SBP was unchanged with combination and decreased with solifenacin monotherapy. Mean changes from baseline to EoT in ECG parameters were generally similar across treatment groups, except for QT interval corrected using Fridericia's formula, which was higher with solifenacin 10 mg (3.30 mseconds) vs. combination (0.49 mseconds) and solifenacin 5 mg (0.77 mseconds). CONCLUSION:The comparable frequency of CV-related TEAEs, changes in vital signs and ECG parameters indicates no synergistic effect on CV safety outcomes when mirabegron and solifenacin are combined.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Drake MJ,MacDiarmid S,Chapple CR,Esen A,Athanasiou S,Cambronero Santos J,Mitcheson D,Herschorn S,Siddiqui E,Huang M,Stoelzel Mdoi
10.1111/ijcp.12944subject
Has Abstractpub_date
2017-05-01 00:00:00issue
5eissn
1368-5031issn
1742-1241journal_volume
71pub_type
杂志文章,随机对照试验abstract::In this journal, Cummins et al reported an experiment that examined clinicians' predictions of causes of death from subjects' pre-morbid photographs. They found that clinicians performed at chance. The validity of two of their other conclusions are challenged. First, that clinicians routinely form impressions of how a...
journal_title:International journal of clinical practice
pub_type: 评论,杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:To explore the association between illicit drug use (IDU) and cardiometabolic disease risk factors (CDRF) in a nationally representative sample of adults. METHODS:The 2005-2008 National Health and Nutrition Examination Surveys data from 20- to 45-year-old adults (n = 8738) were utilised to analyze the relation...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12189
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abstract:AIMS:The IMPROVE observational study evaluated the safety profile and effectiveness of biphasic insulin aspart 30/70 (BIAsp 30) in patients with type 2 diabetes in routine practice in 11 countries. METHODS:Patients who initiated insulin therapy with, or switched existing insulin therapy to, BIAsp 30 in routine care we...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1742-1241.2009.02002.x
更新日期:2009-03-01 00:00:00
abstract:AIMS:To examine the relationship between costs of hyperglycaemia drug treatment and glycemic control amongst people with type 2 diabetes (T2D). METHODS:This observational study utilised data from the QUALIDIAB database on 3,452 T2D patients seen in Diabetes Centers in Argentina. Patients were classified according to t...
journal_title:International journal of clinical practice
pub_type: 杂志文章
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abstract::It is being questioned if Helicobacter pylori infection, which causes a chronic inflammatory response, can increase the frequency and severity of attacks in patients with Familial Mediterranean Fever (FMF) and if the impact of inflammatory response can be diminished by eradication of the infection. To evaluate if ther...
journal_title:International journal of clinical practice
pub_type: 杂志文章
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abstract:AIMS:Although many elderly individuals suffer from type 2 diabetes, the effectiveness of cardioprotective drugs in primary prevention of cardiovascular events in clinical practice in this population has rarely been evaluated. We aimed to assess the effectiveness of, (i) angiotensin converting enzyme inhibitors or angio...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/ijcp.12503
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abstract:PURPOSE:In the setting of an increasing workload for radiologists, this study focuses on the feasibility of skill mixing in breast imaging in a hospital radiology department. METHODS:Two radiological technologists with more than 10 years of experience in performing mammograms were trained in prereading mammograms to s...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2009.02310.x
更新日期:2010-03-01 00:00:00
abstract::We report a case of acute myocardial infarction in an HIV-infected patient without significant coronary artery disease (CAD) risk factors. The patient underwent rescue percutaneous transluminal coronary angioplasty (PTCA), with a successful outcome. We presume a possible pathogenetic role of anti-retroviral therapy an...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2004.00246.x
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abstract::Ranitidine is one of the widely prescribed H2 receptor antagonists in the treatment of peptic ulcer. It is well tolerated and has few side-effects. Vasculitic rash occurring in association with ranitidine has been described. We report a case of a 39-year-old man who developed a purpuric rash, polyarthritis, abdominal ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
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abstract::Twenty cases of tuberculous meningitis were diagnosed at the Hamad Medical Corporation between 1990 and 1995. Most of the patients (90%) were expatriates. The most common presenting features were fever, headache, neck stiffness and altered mental status. Five patients were in stage 1 disease at the time of presentatio...
journal_title:International journal of clinical practice
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1742-1241.2004.00234.x
更新日期:2004-12-01 00:00:00
abstract::Cerebellitis is not a recognised manifestation of Lyme disease. We describe a patient with clinical features of subacute cerebellitis, cerebrospinal fluid (CSF) monocytic pleocytosis, positive CSF Borrelia burgdorferi antibodies, negative brain magnetic resonance imaging and a benign course after treatment with ceftri...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::People with genuine anxiety disorders can be misdiagnosed and mismanaged, because of negative public and professional attitudes to anxiety and the 'worried well'. Misdiagnosis includes not taking symptoms seriously and giving patients pejorative labels such as 'personality disorder' or 'inadequate'. This can lead to m...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::In a previous report the effectiveness of intraperitoneal bupivacaine in reducing pain following laparoscopic cholecystectomy was demonstrated. Other methods of pain relief are commonly used but none has been compared following laparoscopic cholecystectomy. In two further studies we have compared the analgesic effect ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Smoking is the leading risk factor for preventable morbidity and mortality as a result of heart and lung diseases and various forms of cancer. Reimbursement coverage for smoking cessation therapies remains limited in Canada and the United States despite the health and economic benefits of smoking cessation. ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
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更新日期:2011-06-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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abstract::Calcium dobesilate (Doxium) is used in the treatment of diabetic retinopathy. Clinical studies show a slowdown of the progression of the disease after long-term oral treatment. The main action of the drug is related to a reduction of microvascular permeability as measured by different parameters and methods (vitreous ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-04-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
abstract::Though common, the exact incidence and clinical pattern of idiopathic pulmonary fibrosis (IPF) in Gulf countries are not known. The results of a four-year prospective study undertaken in two tertiary hospitals in Kuwait are presented. The mean age at diagnosis of the 52 patients studied was 55.40 +/- 11.87 years. Thir...
journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2000-09-01 00:00:00