Abstract：
AIMS:There is evidence suggesting that the respiratory response to sedation is different in patients with sleep apnoea, which is common in patients with chronic renal failure (CRF). This study examined the respiratory response of sedation with propofol and alfentanil, whose pharmacokinetics are not affected by the renal function, in CRF patients. METHODS:Chronic renal failure patients who underwent arteriovenous-fistular surgery (CRF group) and patients who underwent chemoport insertion (control group) were enrolled in this study. Sedation was induced by infusing propofol 1.5 micro/ml and alfentanil 0.2 micro/kg/min continuously in both groups. In the desaturation study, the respiratory rate and peripheral oxygen saturation in room air were checked. In the apnoea-hypopnoea study, the patient's sedation (Observer's Assessment of Alertness/Sedation) score, apnoea-hypopnoea index (AHI) was recorded using a portable ventilation effort recorder (microMesam) while applying 5 l/min of oxygen through a facial mask. RESULTS:The desaturation event was more common (21.5/h vs. 2/h, p = 0.001) in the CRF patients. Apnoea and hypopnoea (AHI: 13.0 vs. 1.6, p = 0.012, per cent of patients with an AHI > 5: 53.3% vs. 7.1%, p = 0.014) occurred more frequently in the CRF patients but the sedation score was not different. CONCLUSION:Chronic renal failure patients have a higher risk of developing apnoea and hypopnoea during sedation, which highlights the need for careful monitoring and management in these patients.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Lee SM,Kim GH,Lee JJ,Kim JA,Choi SJ,Kim GS,Jung HHdoi
10.1111/j.1742-1241.2007.01443.xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
1-5issue
1eissn
1368-5031issn
1742-1241pii
IJCP1443journal_volume
64pub_type
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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doi：
更新日期：2003-05-01 00:00:00
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journal_title：International journal of clinical practice
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更新日期：2002-04-01 00:00:00
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journal_title：International journal of clinical practice
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doi：10.1111/j.1368-5031.2004.00024.x
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journal_title：International journal of clinical practice
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