Abstract:
OBJECTIVE:Few published studies have examined survival rates for patients with metastatic colorectal cancer (mCRC) by number of lines of treatment received or stage at diagnosis. This study aims to evaluate survival and numbers of lines of treatment in USA mCRC managed care patients. METHODS:To evaluate the impact of chemotherapy/biological on survival of patients with mCRC, adults with a diagnosis of CRC between 1 January 2005 and 31 May 2010 were identified from the Oncology Management registry. Registry data included stage and diagnosis date. Patients with stage IV CRC at original diagnosis or development of metastasis were included. Linked healthcare claims from a large USA database were used to identify lines of treatment after metastasis and patient characteristics. The patient population was enrolled in a commercial health insurance programme, with 10% of patients > 65 years of age. Patients were categorised by lines of treatment received (0, 1, 2, 3+) and stage at original diagnosis (0-3, 4, unknown). Survival following metastasis was evaluated using Cox proportional hazards models controlling for lines of treatment, disease stage, and other patient characteristics. RESULTS:Study population included commercially insured adult patients, ≥ 18 years of age (n = 598, mean age 54, 56% male), 16% of which did not receive chemotherapy/biological therapy after becoming metastatic, and 33% received only 1 line of treatment. Average follow-up was 653 days, and 19% of patients died during the study period. Mean unadjusted length of follow-up was 516, 511, 627 and 930 days for patients who received 0, 1, 2 and 3+ lines of treatment, respectively. In the Cox proportional hazards model, geographical region was the only variable significantly associated with survival (p < 0.05). CONCLUSION:Lines of treatment received and stage at original diagnosis were not statistically significantly associated with survival after metastasis development.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Seal B,Chastek B,Kulakodlu M,Valluri Sdoi
10.1111/ijcp.12543subject
Has Abstractpub_date
2015-02-01 00:00:00pages
251-8issue
2eissn
1368-5031issn
1742-1241journal_volume
69pub_type
杂志文章abstract::High plasminogen activator inhibitor-1 (PAI-1) levels are potential risk factors for cardiovascular disease. The risk profile of white coat hypertension (WCHT) has not yet been completely clear. In this study, we aimed to determine the plasma levels of PAI-1, markers of fibrinolysis and increased cardiovascular diseas...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2004.00119.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The use of herbs and dietary supplements (HDS) alone or concomitantly with medications can potentially increase the risk of adverse events experienced by the patients. This review aims to evaluate the documented HDS-drug interactions and contraindications. METHODS:A structured literature review was...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2012.03008.x
更新日期:2012-11-01 00:00:00
abstract:AIMS:This investigation determined the proportion of adults newly diagnosed as having type-2 diabetes mellitus (T2DM), and ascertained risk predictors for development of self-reported T2DM. METHODS:The US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) survey was a 5-...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2012.02952.x
更新日期:2012-07-01 00:00:00
abstract::Acid suppressive therapy, in the form of proton pump inhibitor (PPI), is widely used in cirrhotic patients, often in indications which are not clearly justified. PPI facilitates enteric bacterial colonisation, overgrowth and translocation, which might predispose to spontaneous bacterial peritonitis. However, observati...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1742-1241.2011.02650.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The regular use of simple analgesics in addition to opioids such as paracetamol (or acetaminophen) is recommended for persistent pain to enhance analgesia. Few studies have examined the frequency and doses of paracetamol among people with chronic non-cancer pain including use above the recommended maximum da...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12716
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Tension-free vaginal tape obturator (TVT-O) and tension-free vaginal tape secur (TVT-S) are common surgeries for the treatment of stress urinary incontinence (SUI), several randomised controlled trials (RCTs) have compared the effects of TVT-O and TVT-S, yet the results remained inconsistent. Therefore, we a...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析
doi:10.1111/ijcp.13506
更新日期:2020-09-01 00:00:00
abstract::To investigate ethnic differences and the effect of age and education on awareness and attitudes of women towards hormone replacement therapy (HRT), we conducted a questionnaire survey of 180 women attending a gynaecology clinic, of whom 152 (84.4%) responded. Seventy-one of the women had heard of HRT. Awareness of HR...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Antihypertensive efficacy must be redefined beyond blood pressure (BP) lowering per se to include reducing the cardiovascular complications of hypertension. Treatment decisions should be based on results from large clinical trials with relevant clinical outcomes. Several recent morbidity and mortality trials with angi...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2005.00446.x
更新日期:2005-02-01 00:00:00
abstract:AIMS OF STUDY:To compare a novel oxidative stress biomarker dynamic thiol/disulphide homoeostasis between patients with lung tuberculosis and healthy controls. METHODS:Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulphide was measured with a new automated spectrom...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13998
更新日期:2021-01-05 00:00:00
abstract:INTRODUCTION:Peripartum cardiomyopathy (PPCM) is an uncommon form of congestive heart failure, afflicting obstetric patients around the time of delivery. The epidemiology of PPCM is infrequently reported. To the best of our knowledge, there has been no report from Asia. OBJECTIVE:To define the prevalence, presentation...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01449.x
更新日期:2009-05-01 00:00:00
abstract::To investigate the influence of the S447X variant in lipoprotein lipase (LPL) gene on the response rate to therapy with the thiazolidinedione pioglitazone. A total of 113 diabetic patients were treated with pioglitazone 30 mg for 10 weeks. Response to the pioglitazone treatment was defined by either a >10% relative re...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章
doi:10.1111/j.1742-1241.2006.01242.x
更新日期:2007-04-01 00:00:00
abstract::The effects of diltiazem treatment on symptoms of chronic anal fissures and their long-term outcome were investigated. One hundred and twelve patients were supplied with 6-week course of 2% diltiazem cream for twice-daily topical application. The medical notes and extended follow-up by telephone for 112 patients were ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2006.00895.x
更新日期:2006-11-01 00:00:00
abstract::Exaggerated reactions to insect bites are characteristic of patients with haemoproliferative disorders, particularly chronic lymphocytic leukaemia (CLL). Skin lesions usually appear after the diagnosis of leukaemia and seem unrelated to laboratory findings, disease course or therapy. Rarely, the eruption may precede t...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2004.00116.x
更新日期:2004-12-01 00:00:00
abstract::We assessed the cost-effectiveness of acarbose in the management of patients with impaired glucose tolerance (IGT) in Sweden, based on progression to type 2 diabetes (T2D) and cardiovascular (CV) events reported in the STOP-NIDDM trial population, including high-risk subgroups. The cost per patient free from T2D was S...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2005.00629.x
更新日期:2005-10-01 00:00:00
abstract::This trial assessed whether a simple clinical tool can be used to stratify patients with diabetes, according to risk of developing foot ulceration. This was a prospective, observational follow-up study of 3526 patients with diabetes (91% type 2 diabetes) attending for routine diabetes care. Mean age was 64.7 (range 15...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2006.00899.x
更新日期:2006-05-01 00:00:00
abstract::Most cases of splenic artery aneurysm are asymptomatic, being found incidentally at the time of investigations (e.g. ultrasound, computed tomography, angiography) or laparotomy for other conditions. Rupture of a splenic artery aneurysm with erosion into the stomach is a rare cause of massive upper gastrointestinal hae...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6...
journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1742-1241.2004.00353.x
更新日期:2005-05-01 00:00:00
abstract::Manifestations of atypical gastroesophageal reflux disease (GORD) are varied, and the presentation of atypical symptoms may occur in the absence of typical symptoms. The most sensitive and specific investigation for GORD is pH monitoring, and its application in atypical disease is utilized throughout this paper as a b...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2004.0081.x
更新日期:2004-01-01 00:00:00
abstract::Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a heterogenous disease with complex pathogenesis. AIM:In this review, we summarise recent progress in the understanding of SLE pathogenesis and discuss implications for the treatment of SLE patients using standard and experimental medications. CONCLUSIONS:The discovery...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01528.x
更新日期:2007-12-01 00:00:00
abstract::Both the incidence of twin pregnancy and the demand for prenatal diagnosis are increasing. Unfortunately, biochemical screening and ultrasound scanning are less reliable for prenatal diagnosis in twin pregnancies than in singletons. Amniocentesis and chorionic villous biopsy are usually diagnostic in singleton pregnan...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Helicobacter pylori infection is one of the most prevalent infections in humans. The high prevalence and the association with peptic ulceration and gastric cancer require simple and non-invasive methods for the diagnosis of the infection. Detection of salivary anti-H. pylori IgG antibodies has advantages compared with...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2005.00495.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the long-term clinical and economic outcomes of biphasic insulin aspart 70/30 (BIAsp 70/30) treatment vs. insulin glargine in insulin naïve, type 2 diabetes patients failing oral antidiabetic drugs in a Swedish setting. METHODS:A published and validated computer simulation model (the CORE Diabet...
journal_title:International journal of clinical practice
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1742-1241.2008.01766.x
更新日期:2008-06-01 00:00:00
abstract::This prospective study describes and evaluates the efficacy of an integrated care pathway for the management of the critically ischaemic diabetic foot patients by a multidisciplinary team. A weekly joint diabetes/vascular/podiatry ward round and outpatient clinic was established where patients were assessed within 7 d...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1368-5031.2006.00953.x
更新日期:2006-06-01 00:00:00
abstract::A 40-year-old woman developed myelopathy manifesting as Brown Sequard syndrome after administration of Anti-venom (polyvalent enzyme-refined equine globulin supposed to neutralise 0.6 mg of standard cobra venom, 0.45 mg of standard krait venom, 0.6 mg of standard Russel's viper venom and 0.45 mg of saw scaled viper ve...
journal_title:International journal of clinical practice
pub_type: 信件
doi:10.1111/j.1368-5031.2004.00201.x
更新日期:2004-06-01 00:00:00
abstract:AIMS:To describe the mechanisms of action of denosumab, a novel antiresorptive agent, contrasting it with other antiresorptive and anabolic osteoporosis treatments. METHODS:Published papers related to the mechanism of action of approved osteoporosis treatments were sought through MEDLINE searches. FINDINGS:Osteoporot...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/ijcp.12022
更新日期:2012-12-01 00:00:00
abstract::Thyroid cancer is uncommon with an estimated lifetime risk of 0.8% for women and 0.3% for men. The incidence appears to be increasing by 4% per year and is currently the eighth commonest cancer in women. Managing thyroid cancer is challenging, as no prospective randomised trials exist. Most of the information is deriv...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2005.00671.x
更新日期:2005-11-01 00:00:00
abstract::Cases of transient global amnesia (TGA) seen by one consultant neurologist over a 4-year period (2002-2005 inclusive) were identified. Of 10 possible cases, eight fulfilled suggested diagnostic criteria. Five cases were seen as ward consultations, three in outpatient clinics; seven were seen in district general hospit...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2006.00897.x
更新日期:2007-02-01 00:00:00
abstract:AIMS:To demonstrate the benefit of the combination amlodipine/valsartan 5/160 mg over amlodipine 10 mg, in producing a lower incidence of peripheral oedema for a comparable mean sitting systolic blood pressure (MSSBP) reduction. METHODS:After a 4-week amlodipine 5 mg run-in phase, inadequately controlled hypertension ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1742-1241.2008.01977.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:We recently described early rigid retrograde endoscopic realignment of the disrupted urethra under caudal anaesthesia in the outpatient setting. This retrospective study was performed to evaluate our medium-term results. PATIENTS AND METHODS:A retrospective review of patients who had early rigid retrograde e...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01481.x
更新日期:2010-01-01 00:00:00