Abstract:
AIMS:To describe the mechanisms of action of denosumab, a novel antiresorptive agent, contrasting it with other antiresorptive and anabolic osteoporosis treatments. METHODS:Published papers related to the mechanism of action of approved osteoporosis treatments were sought through MEDLINE searches. FINDINGS:Osteoporotic fractures carry a substantial burden of morbidity and mortality, but pharmacotherapy can prevent such fractures in high-risk individuals. Antiresorptive drugs (e.g. bisphosphonates, oestrogen, denosumab) reduce bone turnover by distinct mechanisms. Denosumab, a recently approved therapy, is a fully human monoclonal antibody that binds the cytokine RANKL (receptor activator of NFκB ligand), an essential factor initiating bone turnover. RANKL inhibition blocks osteoclast maturation, function and survival, thus reducing bone resorption. In contrast, bisphosphonates bind bone mineral, where they are absorbed by mature osteoclasts, inducing osteoclast apoptosis and suppressing resorption. These differences in mechanism influence both the onset and reversibility of treatment. DISCUSSION:Effective pharmacotherapy is necessary for patients at high risk of fracture. Among the treatment options for postmenopausal osteoporosis, there are significant differences in mechanism and dosing. Denosumab acts by a novel mechanism and is administered twice yearly by subcutaneous injection. Identified by Osteoporosis Canada Clinical Practice Guidelines as a first-line agent for treatment of postmenopausal osteoporosis, denosumab represents an important addition to our treatment options.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Hanley DA,Adachi JD,Bell A,Brown Vdoi
10.1111/ijcp.12022subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1139-46issue
12eissn
1368-5031issn
1742-1241journal_volume
66pub_type
杂志文章,评审abstract::Acid suppressive therapy, in the form of proton pump inhibitor (PPI), is widely used in cirrhotic patients, often in indications which are not clearly justified. PPI facilitates enteric bacterial colonisation, overgrowth and translocation, which might predispose to spontaneous bacterial peritonitis. However, observati...
journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
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更新日期:2011-06-01 00:00:00
abstract::Digitalis has been an old but reliable drug for 240 years. Concerns regarding its clinical indications and benefits still exist in the absence of a reduction in all-cause mortality. While intravenous digitalis is used without question in cases of atrial fibrillation, it is still controversial in sinus rhythm, despite ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
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更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of clinical practice
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-09-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2005.00795.x
更新日期:2006-03-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2003-05-01 00:00:00
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更新日期:2018-10-13 00:00:00
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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更新日期:2014-05-01 00:00:00
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journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
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journal_title:International journal of clinical practice
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更新日期:2014-11-01 00:00:00
abstract::Despite concerns in the 1970s and 1980s about the safety of short-acting beta2-agonists, it is now generally accepted that these agents, used at appropriate doses, provide safe and effective treatment for asthma symptoms. After their introduction, beta2-agonists with a long duration of action--formoterol and salmetero...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2003-10-01 00:00:00
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
pub_type: 杂志文章
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