Abstract：
BACKGROUND:This study was designed to assess clinical and functional outcomes associated with switching to duloxetine treatment in patients with major depressive disorder (MDD) experiencing emotional and painful physical symptoms in their current episode. METHODS:In this 8-week, multinational, multicentre, single-arm, open-label clinical trial, 242 MDD patients were switched to duloxetine 60 mg/day after selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor (SNRI) treatment. The primary analysis compared mean change from baseline in Brief Pain Inventory-Modified Short Form (BPI-SF) interference score between initial responders [≥ 50% reduction from baseline on the 17-item Hamilton Depression Rating Scale (HAMD(17)) Maier subscale] and initial non-responders after 4 weeks. Initial responders continued with duloxetine 60 mg/day. Initial non-responders received duloxetine 120 mg/day for the remaining 4 weeks. Depression, pain, anxiety and functional outcomes were also compared after 8 weeks. RESULTS:BPI-SF interference decreased from baseline in initial responders (n = 108) and initial non-responders (n = 85) after 4 weeks of duloxetine treatment, with greater reductions in initial responders [BPI-SF mean difference in reduction: 1.01 (95% CI 0.42-1.61); p < 0.001]. Reductions in pain interference favouring initial responders were also apparent after 8 weeks [0.68 (95% CI: 0.03-1.33); p = 0.042]. Depression, pain, anxiety and function improved over 8 weeks across patient groups. CONCLUSIONS:Elements of core mood and pain are important residual symptoms following poor treatment response in MDD. Early improvement in these symptoms after switching to duloxetine indicated an increased chance of functional recovery.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Sagman D,McIntosh D,Lee MS,Li H,Ruschel S,Hussain N,Granger RE,Lee AC,Raskin Jdoi
10.1111/j.1742-1241.2010.02546.xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
73-81issue
1eissn
1368-5031issn
1742-1241journal_volume
65pub_type
临床试验,杂志文章,多中心研究abstract：:This prospective study describes and evaluates the efficacy of an integrated care pathway for the management of the critically ischaemic diabetic foot patients by a multidisciplinary team. A weekly joint diabetes/vascular/podiatry ward round and outpatient clinic was established where patients were assessed within 7 d...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2006.00953.x
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to investigate the relationship between the use of medicinal plants and medication adherence in elderly people. METHODS:Observational, cross-sectional study of elderly residents in Cuité-PB, Northeastern Brazil, through a household survey. A stratified proportional and systema...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12773
更新日期：2016-03-01 00:00:00
abstract：:Gas explosion during diathermy gastrotomy is a very rare occurrence. We report on an unusual case of gas explosion during diathermy gastrotomy in a patient with carcinoma of the gastric antrum. ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Mobile smart phones have become increasingly integrated into the practice of doctors and allied medical professionals. Recent studies suggest them to represent reservoirs for pathogens with potential to cause nosocomial infections. This study aimed to investigate the level of contamination on phones used on ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.12448
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To investigate the accuracy of three non-invasive blood pressure (BP) devices in atrial fibrillation (AF) compared with invasive arterial BP. METHODS:One hundred patients aged 45-90 years, 63% male (50 in AF and 50 age matched controls in sinus rhythm [SR]) were identified with arterial lines measuring beat-...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13410
更新日期：2019-08-29 00:00:00
abstract：AIMS:To evaluate in a real-world setting the effectiveness of exenatide once-weekly (ExQW) in patients with T2D and to determine predictors of glycaemic and weight response to this drug at 6 months. METHODS:Observational, retrospective, multicenter study in adult patients with T2D and BMI ≥30 kg/m2 from 4 tertiary Spa...
journal_title：International journal of clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1111/ijcp.13055
更新日期：2018-03-01 00:00:00
abstract：AIMS OF STUDY:To compare a novel oxidative stress biomarker dynamic thiol/disulphide homoeostasis between patients with lung tuberculosis and healthy controls. METHODS:Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulphide was measured with a new automated spectrom...
journal_title：International journal of clinical practice
pub_type： 杂志文章
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abstract：:Alzheimer's disease (AD) is classified mainly as a neurodegenerative disease. Recent research, however, has shown that inflammatory mechanisms are also associated with AD and that they could have a role in contributing to the pathogenesis of this disease. The evidence is based on histopathological brain studies, labor...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Gastric acid is pathogenic in many gastrointestinal disorders, such as gastroesophageal reflux disease and peptic ulcer disease. Proton pump inhibitors (PPIs) are the antisecretory drugs of choice for serious acid-related conditions. Ample recent data exist to explicate virtually every aspect of the clinical managemen...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1368-5031.2005.00517.x
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Once-weekly glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promising results in the treatment of type 2 diabetes. Herein, we compared the efficacy and safety of once-weekly GLP-1RAs with exenatide and liraglutide separately. METHODS:We systematically surveyed the pertinent literature using ...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2007.01481.x
更新日期：2010-01-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1368-5031.2004.00024.x
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:The relationship between psoriasis and cardiomyopathy is understudied in Indian patients. OBJECTIVE:We evaluated psoriasis patients for cardiomyopathy and other echocardiographic abnormalities. METHODS:About 98 (M:F = 67:31) patients with mild to moderate psoriasis aged 18-75 years (mean ± SD = 42.12 ± 12....
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13756
更新日期：2020-10-16 00:00:00
abstract：OBJECTIVE:The aim of this study was to describe the occurrence, angulation and mesialisation ratio of the ectopic eruption of the maxillary permanent first molar (PFM) and its correlation with the pathological resorption of maxillary primary second molar (PSM). METHODS:This retrospective study was performed using the ...
journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13880
更新日期：2020-12-07 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/ijcp.13730
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.13027
更新日期：2017-11-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/j.1742-1241.2011.02805.x
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:In late December 2019 and on 1st January 2020, the coronavirus (COVID-19) infecting humans was first identified in Wuhan, Hubei Province, China. Later cases have also been confirmed worldwide. Coronaviruses are RNA viruses that are phenotypically and genotypically diverse. Globally, as of 6th April 2020, lab...
journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
doi：10.1111/ijcp.13637
更新日期：2020-11-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：10.1111/j.1742-1241.2008.01801.x
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journal_title：International journal of clinical practice
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
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journal_title：International journal of clinical practice
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journal_title：International journal of clinical practice
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更新日期：2004-02-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：International journal of clinical practice
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doi：
更新日期：2003-03-01 00:00:00
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journal_title：International journal of clinical practice
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
